Sijia Yu
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View article: The effectiveness of large language models in medical AI research for physicians: A randomized controlled trial
The effectiveness of large language models in medical AI research for physicians: A randomized controlled trial Open
Physicians offer invaluable clinical insights, but their involvement in medical AI research is hindered by limited technical expertise. We conduct a superiority, open-label, randomized controlled trial involving 64 junior ophthalmologists …
View article: Association Between the Dietary Index for Gut Microbiota and Metabolic Syndrome: Mediation Effects of Albumin and Systemic Immune‐Inflammation Index
Association Between the Dietary Index for Gut Microbiota and Metabolic Syndrome: Mediation Effects of Albumin and Systemic Immune‐Inflammation Index Open
With the development of society, the prevalence of metabolic syndrome (MetS) has been increasing year by year and has become a major global health threat. The dietary index for gut microbiota (DI‐GM), a recently proposed dietary assessment…
View article: Exploring the U-shaped nonlinear relationship of CHG index with metabolic syndrome and mortality risks in metabolic syndrome patients
Exploring the U-shaped nonlinear relationship of CHG index with metabolic syndrome and mortality risks in metabolic syndrome patients Open
The CHG index has a substantial U-shaped nonlinear association with the incidence of MetS and the risk of all-cause and cardiovascular death in patients with MetS. Previous interventions have focused primarily on high-risk extremes, but th…
View article: Estimated glucose disposal rate and its dual role in hyperlipidemia risk and mortality: a secondary analysis of retrospective cohort data from U.S. and Chinese
Estimated glucose disposal rate and its dual role in hyperlipidemia risk and mortality: a secondary analysis of retrospective cohort data from U.S. and Chinese Open
View article: Mutual Inductance‐Based Array Sensor for Continuous Monitoring and Mapping of Localized Brain Deformations
Mutual Inductance‐Based Array Sensor for Continuous Monitoring and Mapping of Localized Brain Deformations Open
The brain undergoes constant dynamic deformations, which are intricately linked to its intrinsic properties and pathological states. However, continuous monitoring of these deformations presents significant challenges due to the limited te…
View article: Oxidative Balance, Nutrition, and Cognitive Function in Older Adults: A Mediation Analysis Using NHANES 2011–2014 Data
Oxidative Balance, Nutrition, and Cognitive Function in Older Adults: A Mediation Analysis Using NHANES 2011–2014 Data Open
Background The global rise in cognitive function impairment (CFI) parallels an aging population. While oxidative stress is considered a contributing factor, its role in CFI remains underexplored. This study examines the relationship betwee…
View article: The association between the dietary index for gut microbiota and frailty: a cross-sectional study
The association between the dietary index for gut microbiota and frailty: a cross-sectional study Open
Background Frailty severely impacts patients’ quality of life and imposes a significant burden on healthcare systems. The Dietary Index for Gut Microbiota (DI-GM) is an emerging dietary indicator, and its association with frailty has not b…
View article: Physiologically Based Modeling of Cefoxitin, Cefazolin, and Piperacillin Pharmacokinetics in Obese and Lean Rats
Physiologically Based Modeling of Cefoxitin, Cefazolin, and Piperacillin Pharmacokinetics in Obese and Lean Rats Open
The prevalence of obesity is rapidly increasing worldwide, however there is a notable gap in understanding how obesity affects the pharmacokinetics of drugs and how dosing should be adjusted in obese population. The goals of this work were…
View article: Association between the triglyceride glucose body mass index and asthma: evidence from NHANES 2011–2018
Association between the triglyceride glucose body mass index and asthma: evidence from NHANES 2011–2018 Open
View article: Multi-omics Integration Reveals Energy Crisis and RHOA/ROCK Signal Pathway as Central Mechanisms in Wooden Breast
Multi-omics Integration Reveals Energy Crisis and RHOA/ROCK Signal Pathway as Central Mechanisms in Wooden Breast Open
View article: Relationship of oxidative balance score to gallstone prevalence and gallbladder surgery in American adults: evidence from NHANES 2017-2020
Relationship of oxidative balance score to gallstone prevalence and gallbladder surgery in American adults: evidence from NHANES 2017-2020 Open
Gallstones represent a common gastrointestinal disorder, affecting approximately 10-20% of the global population. Oxidative stress plays a pivotal role in the pathogenesis of gallstones; however, there remains a lack of effective clinical …
View article: Acute Myeloid Leukemia and Myelodysplastic Neoplasms: Clinical Implications of Myelodysplasia-Related Genes Mutations and TP53 Aberrations
Acute Myeloid Leukemia and Myelodysplastic Neoplasms: Clinical Implications of Myelodysplasia-Related Genes Mutations and TP53 Aberrations Open
Purpose The fifth World Health Organization (WHO) classification (2022 WHO) and International Consensus Classification (ICC) of myeloid neoplasms have recently been published. We reclassified patients according to the revised classificatio…
View article: Association between nutrition-related indicators and non-alcoholic fatty liver disease and advanced liver fibrosis: evidence from NHANES 2017-2020
Association between nutrition-related indicators and non-alcoholic fatty liver disease and advanced liver fibrosis: evidence from NHANES 2017-2020 Open
Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide, and its incidence has been rising in parallel with the prevalence of obesity and diabetes. A critical marker for the progress…
View article: Association between the composite dietary antioxidant index and constipation: Evidence from NHANES 2005–2010
Association between the composite dietary antioxidant index and constipation: Evidence from NHANES 2005–2010 Open
Background Dietary antioxidants have been found to improve various diseases, including digestive, cardiovascular, and urinary disorders. However, the relationship between CDAI and constipation remains unclear. This study aims to investigat…
View article: Association between the oxidative balance score and cognitive function: evidence from NHANES 2011-2014
Association between the oxidative balance score and cognitive function: evidence from NHANES 2011-2014 Open
Background With the global aging population, the prevalence of Cognitive impairment (CI) has significantly increased. Despite extensive research, the role of oxidative stress in CI remains underexplored, with limited studies directly linki…
View article: Association between the composite dietary antioxidant index and constipation: evidence from NHANES 2005-2010
Association between the composite dietary antioxidant index and constipation: evidence from NHANES 2005-2010 Open
Background Dietary antioxidants have been found to improve various diseases, including digestive, cardiovascular, and urinary disorders. However, the relationship between the composite dietary antioxidant index (CDAI) and constipation rema…
View article: Special tissue microbiota such as Cyanobacteria are associated with the immune microenvironment of lung adenocarcinoma
Special tissue microbiota such as Cyanobacteria are associated with the immune microenvironment of lung adenocarcinoma Open
Our study indicated that the lung microbiota played an indispensable role in the CD8+ T cell-mediated tumor immune response. These findings shed light on valuable insights into the intricate interplay between the lung microbiome…
View article: Isoniazid urine spectrophotometry for prediction of serum pharmacokinetics in adults with TB
Isoniazid urine spectrophotometry for prediction of serum pharmacokinetics in adults with TB Open
BACKGROUNDIsoniazid (INH) is an important drug in many TB regimens, and unfavorable treatment outcomes can be caused by suboptimal pharmacokinetics. Dose adjustment can be personalized by measuring peak serum concentrations; however, the p…
View article: Efficacy and safety of repeated transcranial magnetic stimulation combined with escitalopram in the treatment of major depressive disorder: a meta-analysis
Efficacy and safety of repeated transcranial magnetic stimulation combined with escitalopram in the treatment of major depressive disorder: a meta-analysis Open
Objective This study was designed to systematically review the efficacy and safety of repeated transcranial magnetic stimulation (rTMS) combined with escitalopram in treating major depressive disorder (MDD). Methods Databases including Pub…
View article: MC180295 is a highly potent and selective CDK9 inhibitor with preclinical in vitro and in vivo efficacy in cancer
MC180295 is a highly potent and selective CDK9 inhibitor with preclinical in vitro and in vivo efficacy in cancer Open
View article: Association between serum uric acid and blood glucose in diabetic individuals: NHANES 2017- Mar.2020
Association between serum uric acid and blood glucose in diabetic individuals: NHANES 2017- Mar.2020 Open
Studies have shown conceivable relationship among serum uric corrosive (SUA), blood glucose (BG) and diabetes mellitus (DM), yet there are not many which examine the association among SUA and BG. The goal of this study is to help or reject…
View article: Intermediate Hyperglycemia Increases the Risk of All-Cause Mortality in Premature Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention
Intermediate Hyperglycemia Increases the Risk of All-Cause Mortality in Premature Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention Open
NCT05050877.
View article: Simplified urine-based method to detect rifampin underexposure in adults with tuberculosis: a prospective diagnostic accuracy study
Simplified urine-based method to detect rifampin underexposure in adults with tuberculosis: a prospective diagnostic accuracy study Open
Variable pharmacokinetics of rifampin in tuberculosis (TB) treatment can lead to poor outcomes. Urine spectrophotometry is simpler and more accessible than recommended serum-based drug monitoring, but its optimal efficacy in predicting ser…
View article: Wall Motion Score Index Predicts Persistent Moderate or Severe Secondary Mitral Regurgitation and its Prognostic Role in Patients Undergoing Percutaneous Coronary Intervention
Wall Motion Score Index Predicts Persistent Moderate or Severe Secondary Mitral Regurgitation and its Prognostic Role in Patients Undergoing Percutaneous Coronary Intervention Open
Background: Patients with secondary mitral regurgitation (sMR) often present with greater mortality and comorbidity, which may be predicted by some risk factors. This study was designed to investigate the prognostic meaning of the echocard…
View article: Pre-RNA splicing in metabolic homeostasis and liver disease
Pre-RNA splicing in metabolic homeostasis and liver disease Open
The liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their effects on gene expression have revealed considerable tr…
View article: Correction: Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China
Correction: Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China Open
View article: Establishment and assessment of a preclinical model of acute kidney injury induced by contrast media combined acute myocardial ischemia reperfusion surgery
Establishment and assessment of a preclinical model of acute kidney injury induced by contrast media combined acute myocardial ischemia reperfusion surgery Open
Acute kidney injury (AKI) is a common complication after acute myocardial infarction (AMI) in clinical practice, and the majority of previous preclinical models were induced by a single factor. The objective of the present study was to est…
View article: Rifampin urinary excretion to predict serum targets in children with tuberculosis: a prospective diagnostic accuracy study
Rifampin urinary excretion to predict serum targets in children with tuberculosis: a prospective diagnostic accuracy study Open
Objective Pharmacokinetic variability drives tuberculosis (TB) treatment outcomes but measurement of serum drug concentrations for personalised dosing is inaccessible for children in TB-endemic settings. We compared rifampin urine excretio…
View article: Mechanisms of Obesity-Induced Changes in Pharmacokinetics of IgG in Rats
Mechanisms of Obesity-Induced Changes in Pharmacokinetics of IgG in Rats Open
View article: Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China
Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China Open
Background The prevalence of prediabetes is increasing in young adults and patients undergoing coronary angiography. However, whether prediabetes is a considerable risk factor for all-cause mortality remains undetermined in young patients …