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View article: Peripheral T-Cell Non-Hodgkin`S Lymphoma Of The Lip
Peripheral T-Cell Non-Hodgkin`S Lymphoma Of The Lip Open
Introduction: Non-Hodgkin’s lymphoma (NHL) of T-cell origin involving the lips is exceptionally rare and diagnostically challenging. This report describes a 16-year-old male presenting with recurrent swelling of both lips over three months…
View article: The social dimension of apathy: Evidence for a distinct domain from 11,243 individuals across health and neurocognitive disorders
The social dimension of apathy: Evidence for a distinct domain from 11,243 individuals across health and neurocognitive disorders Open
Apathy is a highly prevalent and disabling neuropsychiatric syndrome, but its multi-dimensional structure is a challenge for progress towards better identification and treatment. A critical question is whether social disengagement reflects…
View article: Dynamic updating of spatial working memory across eye movements: a computational investigation of transsaccadic integration
Dynamic updating of spatial working memory across eye movements: a computational investigation of transsaccadic integration Open
The brain continuously integrates rapidly changing visual input across eye movements to maintain stable perception, yet the precise mechanisms underpinning dynamic working memory and how these break down in brain diseases remain unclear. W…
View article: On the relationships between apathy, depression and anhedonia
On the relationships between apathy, depression and anhedonia Open
Although apathy, depression, and anhedonia frequently co-occur, the differences between these syndromes remains poorly characterised. Here, we assessed 4,350 healthy individuals and 235 people with major depressive disorder or on antidepre…
View article: On the relationships between apathy, depression and anhedonia
On the relationships between apathy, depression and anhedonia Open
Background Apathy, depression, and anhedonia are clinically overlapping constructs, which hinders diagnostic clarity and treatment development. This study aimed to comprehensively characterise these syndromes to identify a core set of non-…
View article: OCTAL (Oxford Cognitive Testing Portal): A remote, cross-cultural cognitive assessment detects domain-specific aging and dementia
OCTAL (Oxford Cognitive Testing Portal): A remote, cross-cultural cognitive assessment detects domain-specific aging and dementia Open
The global rise in dementia necessitates scalable cognitive assessments that can evolve to serve both clinical and research applications. We present the Oxford Cognitive Testing Portal (OCTAL), a remote, browser-based platform providing pe…
View article: Reverse Region-to-Entity Annotation for Pixel-Level Visual Entity Linking
Reverse Region-to-Entity Annotation for Pixel-Level Visual Entity Linking Open
Visual Entity Linking (VEL) is a crucial task for achieving fine-grained visual understanding, matching objects within images (visual mentions) to entities in a knowledge base. Previous VEL tasks rely on textual inputs, but writing queries…
View article: On the relationships between apathy, depression and anhedonia
On the relationships between apathy, depression and anhedonia Open
Background Apathy, depression, and anhedonia are clinically overlapping constructs, which hinders diagnostic clarity and treatment development. This study aimed to comprehensively characterise these syndromes to identify a core set of non-…
View article: Investigating the impact of electroconvulsive therapy on brain networks and sleep: an observational study protocol
Investigating the impact of electroconvulsive therapy on brain networks and sleep: an observational study protocol Open
Introduction Electroconvulsive therapy (ECT) is a highly effective treatment for refractory depression, but it may also cause cognitive side effects. Despite decades of use, the mechanisms by which ECT exerts both its antidepressant and co…
View article: Preclinical type 2 diabetes mellitus subtypes: new insights into diabetes, depression and dementia
Preclinical type 2 diabetes mellitus subtypes: new insights into diabetes, depression and dementia Open
This scientific commentary refers to ‘Machine learning reveals connections between preclinical type 2 diabetes subtypes and brain health’ by Yi et al. (https://doi.org/10.1093/brain/awaf057).
View article: Defining brain fog across medical conditions
Defining brain fog across medical conditions Open
'Brain fog' is commonly reported in more than a dozen chronic diseases, but what is it? We review research across conditions which has characterised brain fog and evaluate its definitions and objective correlates. Brain fog has been used t…
View article: Self-versus caregiver-reported apathy across neurological disorders
Self-versus caregiver-reported apathy across neurological disorders Open
Apathy is a prevalent and persistent neuropsychiatric syndrome across many neurological disorders, significantly impacting on both patients and caregivers. We systematically quantified discrepancies between self- and caregiver-reported apa…
View article: Phenoxazinone Synthase-Like Activity of Rationally Designed Heme Enzymes Based on Cytochrome P450bm3
Phenoxazinone Synthase-Like Activity of Rationally Designed Heme Enzymes Based on Cytochrome P450bm3 Open
View article: Self- versus caregiver-reported apathy across neurological disorders
Self- versus caregiver-reported apathy across neurological disorders Open
Apathy is a prevalent and persistent neuropsychiatric syndrome across many neurological disorders, significantly impacting both patients and caregivers. We systematically quantified discrepancies between self- and caregiver-reported apathy…
View article: Reverse Region-to-Entity Annotation for Pixel-Level Visual Entity Linking
Reverse Region-to-Entity Annotation for Pixel-Level Visual Entity Linking Open
Visual Entity Linking (VEL) is a crucial task for achieving fine-grained visual understanding, matching objects within images (visual mentions) to entities in a knowledge base. Previous VEL tasks rely on textual inputs, but writing queries…
View article: Sustained EEG responses to rapidly unfolding stochastic sounds reflect Bayesian inferred reliability tracking
Sustained EEG responses to rapidly unfolding stochastic sounds reflect Bayesian inferred reliability tracking Open
How does the brain track and process rapidly changing sensory information? Current computational accounts suggest that our sensations and decisions arise from the intricate interplay between bottom-up sensory signals and constantly changin…
View article: Diagnostic performance of online cognitive assessment and plasma biomarkers in Alzheimer’s Disease and Subjective Cognitive Impairment using the Oxford Cognitive Testing Portal
Diagnostic performance of online cognitive assessment and plasma biomarkers in Alzheimer’s Disease and Subjective Cognitive Impairment using the Oxford Cognitive Testing Portal Open
Background Plasma biomarkers have emerged as a promising tool to detect the presence of Alzheimer’s disease (AD) when cognitive symptoms have not yet emerged. However, there is also a pressing need to detect and track subtle cognitive chan…
View article: Diagnostic performance of online cognitive assessment and plasma biomarkers in Alzheimer’s Disease and Subjective Cognitive Impairment using the Oxford Cognitive Testing Portal
Diagnostic performance of online cognitive assessment and plasma biomarkers in Alzheimer’s Disease and Subjective Cognitive Impairment using the Oxford Cognitive Testing Portal Open
Background Plasma biomarkers have emerged as a promising tool to detect the presence of Alzheimer’s disease (AD) when cognitive symptoms have not yet emerged. However, there is also a pressing need to detect and track subtle cognitive chan…
View article: TCM practitioners’ attitudes and perceptions regarding the use of Ephedra sinica Stapf: An observational study
TCM practitioners’ attitudes and perceptions regarding the use of Ephedra sinica Stapf: An observational study Open
Objective: To understand the attitudes and perceptions of traditional Chinese medicine (TCM) practitioners in Beijing TCM hospitals regarding the use of Ephedra sinica Stapf (E. sinica, Ma Huang). Methods: A two-stage cross-sectional study…
View article: The ratio of circulating CD56dim NK cells to follicular T helper cells as a promising predictor for disease activity of relapsing-remitting multiple sclerosis
The ratio of circulating CD56dim NK cells to follicular T helper cells as a promising predictor for disease activity of relapsing-remitting multiple sclerosis Open
View article: Relationship of plasma biomarkers to digital cognitive tests in Alzheimer's disease
Relationship of plasma biomarkers to digital cognitive tests in Alzheimer's disease Open
INTRODUCTION A major limitation in Alzheimer's disease (AD) research is the lack of the ability to measure cognitive performance at scale—robustly, remotely, and frequently. Currently, there are no established online digital platforms vali…
View article: Cross-Modal Interactions Between Auditory Attention and Oculomotor Control
Cross-Modal Interactions Between Auditory Attention and Oculomotor Control Open
Microsaccades are small, involuntary eye movements that occur during fixation. Their role is debated with recent hypotheses proposing a contribution to automatic scene sampling. Microsaccadic inhibition (MSI) refers to the abrupt suppressi…
View article: Long COVID is associated with severe cognitive slowing: a multicentre cross-sectional study
Long COVID is associated with severe cognitive slowing: a multicentre cross-sectional study Open
Wellcome Trust (206330/Z/17/Z), NIHR Oxford Health Biomedical Research Centre, the Thüringer Aufbaubank (2021 FGI 0060), German Forschungsgemeinschaft (DFG, FI 1424/2-1) and the Horizon 2020 Framework Programme of the European Union (ITN S…
View article: Sustained EEG responses to rapidly unfolding stochastic sounds reflect precision tracking
Sustained EEG responses to rapidly unfolding stochastic sounds reflect precision tracking Open
The brain is increasingly viewed as a statistical learning machine, where our sensations and decisions arise from the intricate interplay between bottom-up sensory signals and constantly changing expectations regarding the surrounding worl…
View article: Data-Independent Acquisition-Based Quantitative Proteomic Analysis Reveals Potential Salivary Biomarkers of Primary Sjögren’s Syndrome
Data-Independent Acquisition-Based Quantitative Proteomic Analysis Reveals Potential Salivary Biomarkers of Primary Sjögren’s Syndrome Open
Objective As primary Sj?gren's syndrome (pSS) primarily affects the salivary glands, saliva can serve as an indicator of the glands' pathophysiology and the disease's status. This study aims to illustrate the salivary proteomic profiles of…
View article: Generalization of auditory expertise in audio engineers and instrumental musicians
Generalization of auditory expertise in audio engineers and instrumental musicians Open
From auditory perception to general cognition, the ability to play a musical instrument has been associated with skills both related and unrelated to music. However, it is unclear if these effects are bound to the specific characteristics …
View article: Multiple gene-drug prediction tool reveals Rosiglitazone based treatment pathway for non-segmental vitiligo
Multiple gene-drug prediction tool reveals Rosiglitazone based treatment pathway for non-segmental vitiligo Open
Vitiligo is a skin disease characterized by selective loss of melanocytes, which seriously affects the appearance and causes great psychological stress to patients. In this study, we performed a comprehensive analysis of two vitiligo micro…
View article: Long COVID is associated with severe cognitive slowing
Long COVID is associated with severe cognitive slowing Open
Background COVID-19 survivors may suffer from a wide range of chronic cognitive symptoms for months or years as part of post-COVID-19 conditions (PCC). To date, there is no definitive objective cognitive marker for PCC. We hypothesised tha…
View article: Age differentially mediates the relationship between plasma biomarkers and cognition detected by digital screening
Age differentially mediates the relationship between plasma biomarkers and cognition detected by digital screening Open
Background Plasma biomarkers are emerging as a useful tool to measure neurodegeneration, particularly in patients with Alzheimer’s Disease (AD). Digital cognitive testing is also increasingly used to detect cognitive changes in AD. Age is …
View article: Age differentially mediates the relationship between plasma biomarkers and cognition detected by digital screening
Age differentially mediates the relationship between plasma biomarkers and cognition detected by digital screening Open
Background Plasma biomarkers are emerging as a useful tool to measure neurodegeneration, particularly in patients with Alzheimer’s Disease (AD). Digital cognitive testing is also increasingly used to detect cognitive changes in AD. Age is …