Silas Ferrao
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View article: Ikaros Degradation By CC-220 (Iberdomide) Correlates with Normalization of SLE CD4 T Cell Phenotype
Ikaros Degradation By CC-220 (Iberdomide) Correlates with Normalization of SLE CD4 T Cell Phenotype Open
Introduction: CC-220 is a second-generation IMiD drug that degrades members of the IKZF family and is being explored for treating Systemic Lupus Erythematosus (SLE). SLE is driven by an abnormal immune response, and adaptive immune cells s…
View article: Cytochrome P460 Cofactor Maturation Proceeds via Peroxide-Dependent Post-translational Modification
Cytochrome P460 Cofactor Maturation Proceeds via Peroxide-Dependent Post-translational Modification Open
Cytochrome P460s are heme enzymes that oxidize hydroxylamine to nitrous oxide. They bear specialized "heme P460" cofactors that are cross-linked to their host polypeptides by a post-translationally modified lysine residue. Wild-type N. eur…
View article: Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives
Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives Open
Ternary complex structural knowledge enabled elucidation of structure–degradation relationships that will assist the future design of cereblon modulators that avoid GSPT1 toxicity.
View article: Cytochrome P460 Cofactor Maturation Involves a Peroxide- Dependent Post-Translational Modification
Cytochrome P460 Cofactor Maturation Involves a Peroxide- Dependent Post-Translational Modification Open
Cytochrome P460s are heme enzymes that oxidize hydroxylamine to nitrous oxide as part of the biogeochemical nitrogen cycle. They bear unique “heme P460” cofactors that are cross-linked to their host polypeptides by a post-translationally m…
View article: Cereblon covalent modulation through structure-based design of histidine targeting chemical probes
Cereblon covalent modulation through structure-based design of histidine targeting chemical probes Open
Synthetic re-engineering of a surface histidine residue on cereblon using sulfonyl exchange chemistry yielded potent irreversible modulators of the E3 ubiquitin ligase complex, including a molecular glue degrader of the novel neosubstrate …