Sili Wang
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View article: Chinese guidance for the clinical application of adeno-associated virus vector-based gene therapy for hemophilia B (2025)
Chinese guidance for the clinical application of adeno-associated virus vector-based gene therapy for hemophilia B (2025) Open
Currently, factor IX replacement is the mainstay treatment for hemophilia B in clinical practice. However, since the disease cannot be cured, lifelong treatment and frequent infusion is required. In recent years, hemophilia B gene therapy …
View article: Construction of intelligent decision support systems through integration of retrieval-augmented generation and knowledge graphs
Construction of intelligent decision support systems through integration of retrieval-augmented generation and knowledge graphs Open
This article proposes a novel framework for intelligent decision support systems based on retrieval augmented generation models and knowledge graphs, in order to overcome the shortcomings of current approaches. Systems Like Mistral 7B, LLa…
View article: The granulomatous pulmonary nodules induced by tislelizumab in advanced squamous NSCLC: a case report with challenging differential diagnosis
The granulomatous pulmonary nodules induced by tislelizumab in advanced squamous NSCLC: a case report with challenging differential diagnosis Open
This case highlights the diagnostic complexity of ICI-induced granulomatous lung lesions, their steroid responsiveness, and the feasibility of ICIs rechallenge under close monitoring. Pathological confirmation is crucial for the diagnosis,…
View article: Hyperuricemia in Chinese Patients with Mood Disorders: Prevalence, Related Factors, and Predictive Model
Hyperuricemia in Chinese Patients with Mood Disorders: Prevalence, Related Factors, and Predictive Model Open
MD patients treated with lithium carbonate should be closely monitored for uric acid levels. We suggested that hepatic TG accumulation and psychiatric drug-induced hepatocellular damage may contribute to hyperuricemia in patients with mood…
View article: Prediction model of male reproductive function damage caused by CHOP chemotherapy regimen for non-Hodgkin's lymphoma
Prediction model of male reproductive function damage caused by CHOP chemotherapy regimen for non-Hodgkin's lymphoma Open
Objective: The CHOP combined chemotherapy regimen (cyclophosphamide, doxorubicin, vincristine, and prednisone) is commonly used to treat non-Hodgkin Lymphoma（NHL）. While these drugs are effective for cancer treatment, they may have side ef…
View article: Frontiers and hotspots of adipose tissue and NAFLD: a bibliometric analysis from 2002 to 2022
Frontiers and hotspots of adipose tissue and NAFLD: a bibliometric analysis from 2002 to 2022 Open
Background: The annual incidence of non-alcoholic fatty liver disease (NAFLD) continues to rise steadily. In recent years, adipose tissue (AT) has gained recognition as a pivotal contributor to the pathogenesis of NAFLD. Employing bibliome…
View article: Emerging trends and hotspots in the links between the bile acids and <scp>NAFLD</scp> from 2002 to 2022: A bibliometric analysis
Emerging trends and hotspots in the links between the bile acids and <span>NAFLD</span> from 2002 to 2022: A bibliometric analysis Open
Background Non‐alcoholic fatty liver disease (NAFLD) is a metabolic syndrome of the liver, and its incidence is increasing worldwide. Accumulating evidence suggests that bile acids are associated with NAFLD. Although many studies on bile a…
View article: Chemical Disorder in 6H-SiC Irradiated with Both He and Fe Ions Followed by 1500 °C Annealing: Electron Energy-Loss Spectroscopy Analysis
Chemical Disorder in 6H-SiC Irradiated with Both He and Fe Ions Followed by 1500 °C Annealing: Electron Energy-Loss Spectroscopy Analysis Open
A good understanding of the chemical disorder in silicon carbide (SiC) after ion irradiation is crucial for evaluating structural stability in both semiconductor and nuclear power systems. In this study, 6H-SiC single-crystal was irradiate…
View article: Prognostic significance of CD56 expression in patients with multiple myeloma: a meta-analysis
Prognostic significance of CD56 expression in patients with multiple myeloma: a meta-analysis Open
The meta-analysis suggested that CD56 negative patients had a poor prognosis for OS in Asian patients and for PFS in non-Asian patients. Novel drugs didn't show a significant improvement or overcome on the adverse prognosis brought by CD56…
View article: Exploration of Icy Ocean Worlds Using Geophysical Approaches
Exploration of Icy Ocean Worlds Using Geophysical Approaches Open
Geophysics-focused missions and improved geophysical data sets are critical for the future exploration of icy ocean worlds. Of particular interest is the exploration of the Galilean moon, Europa, and the Saturnian moons, Titan and Enceladu…
View article: Indoor Navigation For The Blind And Visually Impaired: Validation And Training Methodology Using Virtual Reality
Indoor Navigation For The Blind And Visually Impaired: Validation And Training Methodology Using Virtual Reality Open
In this thesis we propose a navigation instruction validation tool and an user training tool for PERCEPT system. The validation tool evaluates the navigation instructions using a virtual reality environment by ensuring that each path in th…
View article: Underground Microseismic Event Monitoring and Localization within Sensor Networks
Underground Microseismic Event Monitoring and Localization within Sensor Networks Open
Locating underground microseismic events is important for monitoring subsurface activity and understanding the planetary subsurface evolution. Due to bandwidth limitations, especially in applications involving planetarily-distributed senso…
View article: Quality-preserved Ambient Noise Imaging in Distributed Sensor Networks with Limited Bandwidth
Quality-preserved Ambient Noise Imaging in Distributed Sensor Networks with Limited Bandwidth Open
Earth and Space Science Open Archive This preprint has been submitted to and is under consideration at Other. ESSOAr is a venue for early communication or feedback before peer review. Data may be preliminary.Learn more about preprints prep…
View article: Ixazomib-based frontline therapy in patients with newly diagnosed multiple myeloma in real-life practice showed comparable efficacy and safety profile with those reported in clinical trial: a multi-center study
Ixazomib-based frontline therapy in patients with newly diagnosed multiple myeloma in real-life practice showed comparable efficacy and safety profile with those reported in clinical trial: a multi-center study Open
The induction therapy containing ixazomib, an oral proteasome inhibitor, has shown favorable efficacy and safety in clinical trials, but its experience in real-life remains limited. In routine practice, few patients received ixazomib-based…
View article: Enrichment and single-cell analysis of circulating tumor cells
Enrichment and single-cell analysis of circulating tumor cells Open
This review aims to provide in-depth insights into CTC analysis, including various techniques for isolation of CTCs and single-cell analysis of CTCs, as well as current developmental trends and promising research directions.