Silke Andresen
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View article: Post‐translational modification by the Pgf glycosylation machinery modulates <i>Streptococcus mutans</i> <scp>OMZ175</scp> physiology and virulence
Post‐translational modification by the Pgf glycosylation machinery modulates <i>Streptococcus mutans</i> <span>OMZ175</span> physiology and virulence Open
Streptococcus mutans is commonly associated with dental caries and the ability to form biofilms is essential for its pathogenicity. We recently identified the Pgf glycosylation machinery of S. mutans , responsible for the post‐translationa…
View article: Involvement of the <i>Streptococcus mutans</i> PgfE and GalE 4-epimerases in protein glycosylation, carbon metabolism, and cell division
Involvement of the <i>Streptococcus mutans</i> PgfE and GalE 4-epimerases in protein glycosylation, carbon metabolism, and cell division Open
Streptococcus mutans is a key pathogen associated with dental caries and is often implicated in infective endocarditis. This organism forms robust biofilms on tooth surfaces and can use collagen-binding proteins (CBPs) to efficiently colon…
View article: Post-translational modification by the Pgf glycosylation machinery modulates<i>Streptococcus mutans</i>physiology and virulence
Post-translational modification by the Pgf glycosylation machinery modulates<i>Streptococcus mutans</i>physiology and virulence Open
Streptococcus mutans is a keystone pathogen of dental caries, and the ability to form biofilms is essential for its pathogenicity. We identified a glycosylation machinery (Pgf) in S. mutans that post-translationally modifies two surface-as…
View article: Pathogen inactivation treatment of triple‐dose apheresis platelets with amotosalen and ultraviolet a light
Pathogen inactivation treatment of triple‐dose apheresis platelets with amotosalen and ultraviolet a light Open
Background A triple storage (TS) set allows for pathogen inactivation (PI) treatment of triple‐dose apheresis platelet products with amotosalen + UVA. We evaluated the quality and metabolic parameters of platelet concentrates (PCs) pathoge…
View article: Preparation and Storage of Cryoprecipitate Derived from Amotosalen and UVA-Treated Apheresis Plasma and Assessment of In Vitro Quality Parameters
Preparation and Storage of Cryoprecipitate Derived from Amotosalen and UVA-Treated Apheresis Plasma and Assessment of In Vitro Quality Parameters Open
Cryoprecipitate is a plasma-derived blood product, enriched for fibrinogen, factor VIII, factor XIII, and von Willebrand factor. Due to infectious risk, the use of cryoprecipitate in Central Europe diminished over the last decades. However…
View article: Regulation of <scp>l</scp> - and <scp>d</scp> -Aspartate Transport and Metabolism in Acinetobacter baylyi ADP1
Regulation of <span>l</span> - and <span>d</span> -Aspartate Transport and Metabolism in Acinetobacter baylyi ADP1 Open
A regulatory scheme was revealed in which AalR responds to l -Asp and DarR responds to d -Asp, a molecule with critical signaling functions in many organisms. The RacD-mediated interconversion of these isomers causes overlap in transcripti…
View article: Human Intelectin-1 Promotes Cellular Attachment and Neutrophil Killing of Streptococcus pneumoniae in a Serotype-Dependent Manner
Human Intelectin-1 Promotes Cellular Attachment and Neutrophil Killing of Streptococcus pneumoniae in a Serotype-Dependent Manner Open
Human intelectin-1 (hIntL-1) is a secreted glycoprotein capable of binding exocyclic 1,2-diols within surface glycans of human pathogens such as Streptococcus pneumoniae , Vibrio cholerae , and Helicobacter pylori . For the latter, lectin …
View article: Low-Dose Exposure to Ganglioside-Mimicking Bacteria Tolerizes Human Macrophages to Guillain-Barré Syndrome-Associated Antigens
Low-Dose Exposure to Ganglioside-Mimicking Bacteria Tolerizes Human Macrophages to Guillain-Barré Syndrome-Associated Antigens Open
In this study, we demonstrated that it is possible to tolerize immune cells to potentially dampen the autoreactive proinflammatory immune response against Guillain-Barré syndrome (GBS)-associated antigens. The innate immune response functi…
View article: RNA and Sugars, Unique Properties of Bacteriophages Infecting Multidrug Resistant Acinetobacter radioresistens Strain LH6
RNA and Sugars, Unique Properties of Bacteriophages Infecting Multidrug Resistant Acinetobacter radioresistens Strain LH6 Open
Bacteriophages (phages) are predicted to be the most ubiquitous biological entity on earth, and yet, there are still vast knowledge gaps in our understanding of phage diversity and phage–host interactions. Approximately one hundred Acineto…
View article: NF-κB regulates neuronal ankyrin-G via a negative feedback loop
NF-κB regulates neuronal ankyrin-G via a negative feedback loop Open
The axon initial segment (AIS) is a neuronal compartment defined by ankyrin-G expression. We here demonstrate that the IKK-complex co-localizes and interacts with the cytoskeletal anchor protein ankyrin-G in immunoprecipitation and proximi…