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View article: CLL to Richter syndrome: Integrating network strategies with experiments elucidating disease drivers and personalized therapies
CLL to Richter syndrome: Integrating network strategies with experiments elucidating disease drivers and personalized therapies Open
Chronic lymphocytic leukemia (CLL) is a common neoplasm that carries the risk of transformation into Richter’s syndrome (RS), a highly aggressive B cell lymphoma with poor prognosis. Limited availability of animal models and cell lines hin…
View article: Uncovering the Understanding of the Concept of Patient Similarity in Cancer Research and Treatment: Scoping Review
Uncovering the Understanding of the Concept of Patient Similarity in Cancer Research and Treatment: Scoping Review Open
Background Patient similarity is a fundamental concept in precision oncology, offering a pathway to personalized medicine by identifying patterns and shared characteristics among patients. This concept enables stratification into clinicall…
View article: Uncovering the Understanding of the Concept of Patient Similarity in Cancer Research and Treatment: Scoping Review (Preprint)
Uncovering the Understanding of the Concept of Patient Similarity in Cancer Research and Treatment: Scoping Review (Preprint) Open
BACKGROUND Patient similarity is a fundamental concept in precision oncology, offering a pathway to personalized medicine by identifying patterns and shared characteristics among patients. This concept enables stratification into clinical…
View article: Identifications of Similarity Metrics for Patients With Cancer: Protocol for a Scoping Review
Identifications of Similarity Metrics for Patients With Cancer: Protocol for a Scoping Review Open
Background Understanding the similarities of patients with cancer is essential to advancing personalized medicine, improving patient outcomes, and developing more effective and individualized treatments. It enables researchers to discover …
View article: Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer—Results of the prospective multicenter PERMAD trial
Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer—Results of the prospective multicenter PERMAD trial Open
Background Anti-vascular endothelial growth factor (VEGF) monoclonal antibodies (mAbs) are widely used for tumor treatment, including metastatic colorectal cancer (mCRC). So far, there are no biomarkers that reliably predict resistance to …
View article: Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer using a multi-marker panel and a machine-learning approach: Final results of the prospective multicenter PERMAD trial.
Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer using a multi-marker panel and a machine-learning approach: Final results of the prospective multicenter PERMAD trial. Open
204 Background: Anti-vascular endothelial growth factor (VEGF) monoclonal antibodies (mAbs) are widely used for tumor treatment, including metastatic colorectal cancer (mCRC). So far, there are no biomarkers that reliably predict resistanc…
View article: GatekeepR: an R Shiny application for the identification of nodes with high dynamic impact in Boolean networks
GatekeepR: an R Shiny application for the identification of nodes with high dynamic impact in Boolean networks Open
Motivation Boolean networks can serve as straightforward models for understanding processes such as gene regulation, and employing logical rules. These rules can either be derived from existing literature or by data-driven approaches. Howe…
View article: The Necessity of Interoperability to Uncover the Full Potential of Digital Health Devices
The Necessity of Interoperability to Uncover the Full Potential of Digital Health Devices Open
Personalized health care can be optimized by including patient-reported outcomes. Standardized and disease-specific questionnaires have been developed and are routinely used. These patient-reported outcome questionnaires can be simple pape…
View article: A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective
A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective Open
View article: Leveraging quantum computing for dynamic analyses of logical networks in systems biology
Leveraging quantum computing for dynamic analyses of logical networks in systems biology Open
View article: <i>CANTATA—</i>prediction of missing links in Boolean networks using genetic programming
<i>CANTATA—</i>prediction of missing links in Boolean networks using genetic programming Open
Motivation Biological processes are complex systems with distinct behaviour. Despite the growing amount of available data, knowledge is sparse and often insufficient to investigate the complex regulatory behaviour of these systems. Moreove…
View article: Response to the letter to the editor: On the feasibility of dynamical analysis of network models of biochemical regulation
Response to the letter to the editor: On the feasibility of dynamical analysis of network models of biochemical regulation Open
We here respond to the points raised in a recent letter to the editor on the feasibility of dynamical analyses in Boolean networks, referring to our manuscript "Capturing dynamic relevance in Boolean networks using graph theoretical measur…
View article: Interaction Empowerment in Mobile Health: Concepts, Challenges, and Perspectives
Interaction Empowerment in Mobile Health: Concepts, Challenges, and Perspectives Open
In its most trending interpretation, empowerment in health care is implemented as a patient-centered approach. In the same sense, many mobile health (mHealth) apps are being developed with a primary focus on the individual user. The integr…
View article: Identification of dynamic driver sets controlling phenotypical landscapes
Identification of dynamic driver sets controlling phenotypical landscapes Open
Controlling phenotypical landscapes is of vital interest to modern biology. This task becomes highly demanding because cellular decisions involve complex networks engaging in crosstalk interactions. Previous work on control theory indicate…
View article: Metadata Correction: Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System
Metadata Correction: Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System Open
[This corrects the article DOI: 10.2196/27348.].
View article: Metadata Correction: Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System (Preprint)
Metadata Correction: Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System (Preprint) Open
View article: Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System
Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System Open
Background Overcoming the COVID-19 crisis requires new ideas and strategies for online communication of personal medical information and patient empowerment. Rapid testing of a large number of subjects is essential for monitoring and delay…
View article: Supporting Medical Staff from Psycho-Oncology with Smart Mobile Devices: Insights into the Development Process and First Results
Supporting Medical Staff from Psycho-Oncology with Smart Mobile Devices: Insights into the Development Process and First Results Open
Cancer is a very distressing disease, not only for the patients themselves, but also for their family members and relatives. Therefore, patients are regularly monitored to decide whether psychological treatment is necessary and applicable.…
View article: Capturing dynamic relevance in Boolean networks using graph theoretical measures
Capturing dynamic relevance in Boolean networks using graph theoretical measures Open
Motivation Interaction graphs are able to describe regulatory dependencies between compounds without capturing dynamics. In contrast, mathematical models that are based on interaction graphs allow to investigate the dynamics of biological …
View article: Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer
Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer Open
Cofilin-1 (CFL1) overexpression in pancreatic cancer correlates with high invasiveness and shorter survival. Besides a well-documented role in actin remodeling, additional cellular functions of CFL1 remain poorly understood. Here, we unrav…
View article: Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System (Preprint)
Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System (Preprint) Open
BACKGROUND Overcoming the COVID-19 crisis requires new ideas and strategies for online communication of personal medical information and patient empowerment. Rapid testing of a large number of subjects is essential for monitoring and dela…
View article: Reconstructing Boolean network ensembles from single-cell data for unraveling dynamics in the aging of human hematopoietic stem cells
Reconstructing Boolean network ensembles from single-cell data for unraveling dynamics in the aging of human hematopoietic stem cells Open
View article: Perspective on mHealth Concepts to Ensure Users’ Empowerment–From Adverse Event Tracking for COVID-19 Vaccinations to Oncological Treatment
Perspective on mHealth Concepts to Ensure Users’ Empowerment–From Adverse Event Tracking for COVID-19 Vaccinations to Oncological Treatment Open
Mobile applications have increasingly entered the healthcare sector. Besides being daily companions, so-called mHealth applications have the potential to enable individuals to collect data, document issues, and share them with healthcare p…
View article: YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion
YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion Open
Liver cholestasis is a chronic liver disease and a major health problem worldwide. Cholestasis is characterised by a decrease in bile flow due to impaired secretion by hepatocytes or by obstruction of bile flow through intra- or extrahepat…