Thomas Ethofer
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View article: Aperiodic Activity Reflects Pathologic Waveform Shapes in Focal Epilepsy
Aperiodic Activity Reflects Pathologic Waveform Shapes in Focal Epilepsy Open
Epilepsy constitutes a clinically manifest excitability disorder that is characterized by aberrant electrophysiological activity in the electroencephalogram (EEG). The correct identification of the seizure onset zone relies on the visual d…
View article: Predicting functional outcome using machine learning and large language models: A transdiagnostic approach in a young, help-seeking population (Preprint)
Predicting functional outcome using machine learning and large language models: A transdiagnostic approach in a young, help-seeking population (Preprint) Open
BACKGROUND Functional impairments associated with mental health conditions are on the rise. Predicting functional outcomes may improve the targeting of preventive interventions. While prognostic models have primarily focused on psychosis,…
View article: Support vector machines predict postoperative memory outcomes in temporal lobe epilepsies
Support vector machines predict postoperative memory outcomes in temporal lobe epilepsies Open
Objective We aimed to predict the side of epilepsy as well as the pre‐ and postoperative verbal and nonverbal memory performance in a cohort of left and right temporal lobe epilepsy (TLE) patients based on hippocampal activations during th…
View article: Fiber architecture in the human ventromedial striatum and its relation with the bed nucleus of the stria terminalis
Fiber architecture in the human ventromedial striatum and its relation with the bed nucleus of the stria terminalis Open
The bed nucleus of the stria terminalis (BST) and the ventromedial striatum (consisting of the head of the caudate nucleus (hCN) and the nucleus accumbens (NAcc)) are both part of complex, foremost limbic networks involved in a variety of …
View article: Connectome-based disentangling of epilepsy networks from insular stereoelectroencephalographic leads
Connectome-based disentangling of epilepsy networks from insular stereoelectroencephalographic leads Open
Objective Epilepsy is considered as a network disorder of interacting brain regions. The propagation of local epileptic activity from the seizure onset zone (SOZ) along neuronal networks determines the semiology of seizures. However, in hi…
View article: Aperiodic activity indexes neural hyperexcitability in generalized epilepsy
Aperiodic activity indexes neural hyperexcitability in generalized epilepsy Open
Generalized epilepsy (GE) encompasses a heterogenous group of hyperexcitability disorders that clinically manifest as seizures. At the whole-brain level, distinct seizure patterns as well as interictal epileptic discharges (IEDs) reflect k…
View article: The impact of emotional dysregulation and comorbid depressive symptoms on clinical features, brain arousal, and treatment response in adults with ADHD
The impact of emotional dysregulation and comorbid depressive symptoms on clinical features, brain arousal, and treatment response in adults with ADHD Open
Introduction The role of emotional dysregulation (ED) in attention-deficit/hyperactivity disorder (ADHD) has become an important issue. This study, in which we analyzed data from a predictive pharmaco-EEG-trial, aimed to examine whether sy…
View article: Breath-Hold-Triggered BOLD fMRI in Drug-Resistant Nonlesional Focal Epilepsy—A Pilot Study
Breath-Hold-Triggered BOLD fMRI in Drug-Resistant Nonlesional Focal Epilepsy—A Pilot Study Open
Purpose Individuals with drug-resistant epilepsy may benefit from epilepsy surgery. In nonlesional cases, where no epileptogenic lesion can be detected on structural magnetic resonance imaging, multimodal neuroimaging studies are required.…
View article: Investigating the effect of hippocampal sclerosis on parietal memory network
Investigating the effect of hippocampal sclerosis on parietal memory network Open
Objective We aimed to investigate differences in episodic memory networks between patients with temporal lobe epilepsy (TLE) due to hippocampal sclerosis and healthy controls, especially with regards to the parietal memory network (PMN), a…
View article: Machine Learning Prediction of Estimated Risk for Bipolar Disorders Using Hippocampal Subfield and Amygdala Nuclei Volumes
Machine Learning Prediction of Estimated Risk for Bipolar Disorders Using Hippocampal Subfield and Amygdala Nuclei Volumes Open
The pathophysiology of bipolar disorder (BD) remains mostly unclear. Yet, a valid biomarker is necessary to improve upon the early detection of this serious disorder. Patients with manifest BD display reduced volumes of the hippocampal sub…
View article: Prediction of estimated risk for bipolar disorder using machine learning and structural MRI features
Prediction of estimated risk for bipolar disorder using machine learning and structural MRI features Open
Background Individuals with bipolar disorder are commonly correctly diagnosed a decade after symptom onset. Machine learning techniques may aid in early recognition and reduce the disease burden. As both individuals at risk and those with …
View article: Robot‐assisted stereoencephalography vs subdural electrodes in the evaluation of temporal lobe epilepsy
Robot‐assisted stereoencephalography vs subdural electrodes in the evaluation of temporal lobe epilepsy Open
Objective Invasive video‐electroencephalography (iVEEG) is the gold standard for evaluation of refractory temporal lobe epilepsy before second stage resective surgery (SSRS). Traditionally, the presumed seizure onset zone (SOZ) has been co…
View article: Machine Learning Prediction of Estimated Risk for Bipolar Disorders Using Hippocampal Subfield and Amygdala Nuclei Volumes
Machine Learning Prediction of Estimated Risk for Bipolar Disorders Using Hippocampal Subfield and Amygdala Nuclei Volumes Open
The pathophysiology of bipolar disorder (BD) remains mostly unclear. Yet, a valid biomarker is necessary to improve early detection of this serious disorder. Patients with manifest BD display reduced volumes of the hippocampal subfields an…
View article: Big Field of View MRI T1w and FLAIR Template - NMRI225
Big Field of View MRI T1w and FLAIR Template - NMRI225 Open
Image templates are a common tool for neuroscience research. Often, they are used for spatial normalization of magnetic resonance imaging (MRI) data, which is a necessary procedure for analyzing brain morphology and function via voxel-base…
View article: Multi-spectral diffusion MRI mega-analysis in genetic generalized epilepsy: Relation to outcomes
Multi-spectral diffusion MRI mega-analysis in genetic generalized epilepsy: Relation to outcomes Open
We provide evidence that clinically defined GGE as a whole and GGE-subtypes harbor marked microstructural differences detectable with diffusion MRI. Moreover, we found an association between microstructural changes and treatment resistance…
View article: Linking neuronal and hemodynamic network signatures in the resting human brain
Linking neuronal and hemodynamic network signatures in the resting human brain Open
Despite several studies investigating the relationship between blood-oxygen-level-dependent functional MRI (BOLD-fMRI) and neuroelectric activity, our understanding is rather incomplete. For instance, the canonical hemodynamic response fun…
View article: Correlates of individual voice and face preferential responses during resting state
Correlates of individual voice and face preferential responses during resting state Open
Human nonverbal social signals are transmitted to a large extent by vocal and facial cues. The prominent importance of these cues is reflected in specialized cerebral regions which preferentially respond to these stimuli, e.g. the temporal…
View article: EEG Data Quality: Determinants and Impact in a Multicenter Study of Children, Adolescents, and Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
EEG Data Quality: Determinants and Impact in a Multicenter Study of Children, Adolescents, and Adults with Attention-Deficit/Hyperactivity Disorder (ADHD) Open
Electroencephalography (EEG) represents a widely established method for assessing altered and typically developing brain function. However, systematic studies on EEG data quality, its correlates, and consequences are scarce. To address thi…
View article: Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders
Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders Open
In this study, shared neurobiologic processes were associated with differences in cortical thickness across multiple psychiatric disorders. These processes implicate a common role of prenatal development and postnatal functioning of the ce…
View article: Pseudo-hyperscanning shows common neural activity during face-to-face communication of affect to be associated with shared affective feelings but not with mere emotion recognition
Pseudo-hyperscanning shows common neural activity during face-to-face communication of affect to be associated with shared affective feelings but not with mere emotion recognition Open
Current theories in cognitive neuroscience assume that internal simulation, i.e., the reproduction of brain activity underlying another person's inner state and behaviour in the perceiver's brain, plays an important role in understanding o…
View article: The Neural Correlates of Face-Voice-Integration in Social Anxiety Disorder
The Neural Correlates of Face-Voice-Integration in Social Anxiety Disorder Open
Faces and voices are very important sources of threat in social anxiety disorder (SAD), a common psychiatric disorder where core elements are fears of social exclusion and negative evaluation. Previous research in social anxiety evidenced …
View article: Properties of face localizer activations and their application in functional magnetic resonance imaging (fMRI) fingerprinting
Properties of face localizer activations and their application in functional magnetic resonance imaging (fMRI) fingerprinting Open
Functional localizers are particularly prevalent in functional magnetic resonance imaging (fMRI) studies concerning face processing. In this study, we extend the knowledge on face localizers regarding four important aspects: First, activat…
View article: Unravelling the brain networks driving spike‐wave discharges in genetic generalized epilepsy—common patterns and individual differences
Unravelling the brain networks driving spike‐wave discharges in genetic generalized epilepsy—common patterns and individual differences Open
Summary Objective Genetic generalized epilepsies ( GGEs ) are characterized by generalized spike‐wave discharges ( GSWD s) in electroencephalography ( EEG ) recordings without underlying structural brain lesions. The origin of the epilepti…