Silke Frey
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View article: The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis
The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis Open
Here we show that soluble CD83 induces the resolution of inflammation in an antigen-induced arthritis (AIA) model. Joint swelling and the arthritis-related expression levels of IL-1β, IL-6, RANKL, MMP9, and OC-Stamp were strongly reduced, …
View article: Importance of the PD-1/PD-L1 Axis for Malignant Transformation and Risk Assessment of Oral Leukoplakia
Importance of the PD-1/PD-L1 Axis for Malignant Transformation and Risk Assessment of Oral Leukoplakia Open
Background: The programmed cell death ligand 1/programmed cell death receptor 1 (PD-L1/PD-1) Immune Checkpoint is an important modulator of the immune response. Overexpression of the receptor and its ligands is involved in immunosuppressio…
View article: Zoledronate Causes a Systemic Shift of Macrophage Polarization towards M1 In Vivo
Zoledronate Causes a Systemic Shift of Macrophage Polarization towards M1 In Vivo Open
Background: Immunomodulatory properties of bisphosphonates (BP) are suggested to contribute to the development of medication-associated osteonecrosis of the jaw (MRONJ). Furthermore, bisphosphonate-derived immune modulation might contribut…
View article: Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases
Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases Open
Generalized pustular psoriasis (GPP) is a severe multi-systemic inflammatory disease characterized by neutrophilic pustulosis and triggered by pro-inflammatory IL-36 cytokines in skin. While 19%-41% of affected individuals harbor bi-alleli…
View article: Structural insights into heme binding to IL-36α proinflammatory cytokine
Structural insights into heme binding to IL-36α proinflammatory cytokine Open
Cytokines of the interleukin (IL)-1 family regulate immune and inflammatory responses. The recently discovered IL-36 family members are involved in psoriasis, rheumatoid arthritis, and pulmonary diseases. Here, we show that IL-36α interact…
View article: Interleukin‐36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts
Interleukin‐36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts Open
The IL‐1 family member IL‐36α has proinflammatory and pathogenic properties in psoriasis. IL‐36α binds to the IL‐36 receptor leading to nuclear factor kappa B/mitogen activated protein kinase mediated cytokine release. The IL‐36R antagonis…
View article: The genetic basis for most patients with pustular skin disease remains elusive
The genetic basis for most patients with pustular skin disease remains elusive Open
The identification of IL36RN mutation carriers harbouring additional rare variants in CARD14 or AP1S3 indicates a more complex mode of inheritance of pustular psoriasis. Our results suggest that, in heterozygous IL36RN mutation carriers, t…
View article: Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction
Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction Open
The interleukin (IL)-1 family member IL-33 has been described as intracellular alarmin with broad roles in wound healing, skin inflammation but also autoimmunity. Its dichotomy between full length (fl) IL-33 and the mature (m) form of IL-3…