Silke Matysik
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View article: Rare Cholesterol Related Disorders – A Sterolomic Library for Diagnosis and Monitoring of Diseases
Rare Cholesterol Related Disorders – A Sterolomic Library for Diagnosis and Monitoring of Diseases Open
Cholesterol is an essential molecule in all animals, it can be made by de novo synthesis and can be taken up from the diet. Inherited disorders of cholesterol synthesis, metabolism and transport lead to disease, often with neurological sig…
View article: Unique sterol metabolite shifts in inflammatory bowel disease and primary sclerosing cholangitis
Unique sterol metabolite shifts in inflammatory bowel disease and primary sclerosing cholangitis Open
Inflammatory bowel disease (IBD) triggers chronic intestinal inflammation and is linked to primary sclerosing cholangitis (PSC). Cholesterol homeostasis, tightly regulated under normal conditions, becomes disrupted in both inflammation and…
View article: The Problem of Consumer Ethics in the Context of AI Application - Scoping Review
The Problem of Consumer Ethics in the Context of AI Application - Scoping Review Open
View article: Exploration of the Lipid Profile of Edible Oleaginous Microgreens by Mass Spectrometry-Based Lipidomics
Exploration of the Lipid Profile of Edible Oleaginous Microgreens by Mass Spectrometry-Based Lipidomics Open
The spreading awareness of the health benefits associated with the consumption of plant-based foods is fueling the market of innovative vegetable products, including microgreens, recognized as a promising source of bioactive compounds. To …
View article: The Problem of Consumer Ethics in the Context of AI Application - Scoping Review
The Problem of Consumer Ethics in the Context of AI Application - Scoping Review Open
View article: High-fat diet impact on intestinal cholesterol conversion by the microbiota and serum cholesterol levels
High-fat diet impact on intestinal cholesterol conversion by the microbiota and serum cholesterol levels Open
Cholesterol-to-coprostanol conversion by the intestinal microbiota has been suggested to reduce intestinal and serum cholesterol availability, but the relationship between intestinal cholesterol conversion and the gut microbiota, dietary h…
View article: A targeted GC-MS/MS approach for the determination of eight sterols in microgreen and mature plant material
A targeted GC-MS/MS approach for the determination of eight sterols in microgreen and mature plant material Open
View article: Systemwide effects of ER-intracellular membrane contact site disturbance in primary endothelial cells
Systemwide effects of ER-intracellular membrane contact site disturbance in primary endothelial cells Open
Membrane contact sites (MCS) make up a crucial route of inter-organelle non-vesicular transport within the cell. Multiple proteins are involved in this process, which includes the ER-resident proteins vesicle associated membrane protein as…
View article: Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer
Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer Open
Western diet is an important risk factor for the development of sporadic colorectal cancer (CRC). Dietary fat stimulates bile acid (BA) production by the host and their conversion to secondary BAs by 7α-dehydroxylating (7αDH+) bacteria, bu…
View article: Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior
Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior Open
Background Obesity and related co-morbidities represent a major health challenge nowadays, with a rapidly increasing incidence worldwide. The gut microbiome has recently emerged as a key modifier of human health that can affect the develop…
View article: Short‐chain fatty acids and bile acids in human faeces are associated with the intestinal cholesterol conversion status
Short‐chain fatty acids and bile acids in human faeces are associated with the intestinal cholesterol conversion status Open
Background and Purpose The analysis of human faecal metabolites can provide an insight into metabolic interactions between gut microbiota and the host organism. The creation of metabolic profiles in faeces has received little attention unt…
View article: Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia
Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia Open
Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of ca…
View article: A Multi-omics Approach to Unraveling the Microbiome-Mediated Effects of Arabinoxylan Oligosaccharides in Overweight Humans
A Multi-omics Approach to Unraveling the Microbiome-Mediated Effects of Arabinoxylan Oligosaccharides in Overweight Humans Open
The use of dietary fiber food supplementation as a strategy to reduce the burden of diet-related diseases is a matter of study given its cost-effectiveness and the positive results demonstrated in clinical trials. This multi-omics assessme…
View article: First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods
First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods Open
View article: Quantification of Fecal Short Chain Fatty Acids by Liquid Chromatography Tandem Mass Spectrometry—Investigation of Pre-Analytic Stability
Quantification of Fecal Short Chain Fatty Acids by Liquid Chromatography Tandem Mass Spectrometry—Investigation of Pre-Analytic Stability Open
Short chain fatty acids (SCFAs) are generated by the degradation and fermentation of complex carbohydrates, (i.e., dietary fiber) by the gut microbiota relevant for microbe–host communication. Here, we present a method for the quantificati…
View article: Arabinoxylan oligosaccharides and polyunsaturated fatty acid effects on gut microbiota and metabolic markers in overweight individuals with signs of metabolic syndrome: A randomized cross-over trial
Arabinoxylan oligosaccharides and polyunsaturated fatty acid effects on gut microbiota and metabolic markers in overweight individuals with signs of metabolic syndrome: A randomized cross-over trial Open
View article: International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods
International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods Open
View article: OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism
OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism Open
View article: Effects of supplemented isoenergetic diets varying in cereal fiber and protein content on the bile acid metabolic signature and relation to insulin resistance
Effects of supplemented isoenergetic diets varying in cereal fiber and protein content on the bile acid metabolic signature and relation to insulin resistance Open
View article: Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells
Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells Open
Adrenocortical carcinoma (ACC) is a rare malignancy that harbors a dismal prognosis in advanced stages. Mitotane is approved as an orphan drug for treatment of ACC and counteracts tumor growth and steroid hormone production. Despite seriou…
View article: Accurate and reliable quantification of 25-hydroxy-vitamin D species by liquid chromatography high-resolution tandem mass spectrometry
Accurate and reliable quantification of 25-hydroxy-vitamin D species by liquid chromatography high-resolution tandem mass spectrometry Open
In general, mass spectrometric quantification of small molecules in routine laboratory testing utilizes liquid chromatography coupled to low mass resolution triple-quadrupole mass spectrometers (QQQs). Here we introduce high-resolution tan…