Fernando de Carvalho da Silva
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View article: Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application
Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application Open
Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged a…
View article: Design, Synthesis, and In Vitro Evaluation of 4-(Arylchalcogenyl)methyl)-1H-1,2,3-triazol-1-yl-menadione: Exploring Their Potential Against Tuberculosis
Design, Synthesis, and In Vitro Evaluation of 4-(Arylchalcogenyl)methyl)-1H-1,2,3-triazol-1-yl-menadione: Exploring Their Potential Against Tuberculosis Open
Background/Objectives: In this study, a novel series of 4-(arylchalcogenyl)methyl)-1H-1,2,3-Triazol-1-yl-menadione derivatives were synthesized to explore their potential as new antituberculosis (anti-TB) agents. Selenium-containing compou…
View article: Recent Advances in the Application of Coumarins as Photosensitizers for the Construction of a Dye-Sensitized Solar Cell
Recent Advances in the Application of Coumarins as Photosensitizers for the Construction of a Dye-Sensitized Solar Cell Open
Dye-sensitized solar cells (DSSCs) have emerged as a promising alternative in photovoltaic energy, owing to their efficiency, cost-effectiveness, and versatility. Sensitizers are crucial in efficiently converting solar energy into electric…
View article: Direct Lawsone O-Alkylation Employing Sulfonic Acid-Functionalized Chitosan as a Biodegradable Organocatalyst
Direct Lawsone O-Alkylation Employing Sulfonic Acid-Functionalized Chitosan as a Biodegradable Organocatalyst Open
An environmentally friendly, cheap, and scalable protocol for direct lawsone O-alkylation employing different alcohols using acid chitosan (CS-SO3H) as a heterogeneous organocatalyst is described herein for the first time. A wid…
View article: Mechanochemistry Metal-Free Synthesis and Molecular Modeling Study of 4-Arylamino-1,2-naphthoquinones by Csp2-Csp2 Bond Formation
Mechanochemistry Metal-Free Synthesis and Molecular Modeling Study of 4-Arylamino-1,2-naphthoquinones by Csp2-Csp2 Bond Formation Open
The present work explores the mechanochemical synthesis and computational study of C–C bond formation at the C-4 position of sodium 1,2-naphthoquinone-4-sulfonate (1, β-NQSNa) with dialkylanilines (2a-2f). This is the first example of usin…
View article: Exploring the Synthesis and Bioactive Properties of Coumarin-1,2,3-Triazole Conjugates
Exploring the Synthesis and Bioactive Properties of Coumarin-1,2,3-Triazole Conjugates Open
A survey of the literature reveals that both coumarin and the 1,2,3-triazole nucleus have important and well-recognized biological and pharmaceutical activities. Furthermore, these fused scaffolds have demonstrated biological significance,…
View article: 2-Phenyl-2H-1,2,3-Triazole-Oxime: oral anti-hyperglycemic effect and in vitro DMPK properties
2-Phenyl-2H-1,2,3-Triazole-Oxime: oral anti-hyperglycemic effect and in vitro DMPK properties Open
View article: Heterogeneous organocatalysis: the proline case
Heterogeneous organocatalysis: the proline case Open
l -Proline organocatalyst immobilization (impregnation, intercalation, grafting) enables recovery and reuse in large-scale asymmetric transformations.
View article: Correction: Heterogeneous organocatalysis: the proline case
Correction: Heterogeneous organocatalysis: the proline case Open
Correction for ‘Heterogeneous organocatalysis: the proline case’ by Gustavo Senra G. de Carvalho et al. , RSC Adv. , 2025, 15 , 22469–22504, https://doi.org/10.1039/D5RA02331A.
View article: The Central Role of the Journal of the Brazilian Chemical Society within the Editorial Activities of the SBQ
The Central Role of the Journal of the Brazilian Chemical Society within the Editorial Activities of the SBQ Open
View article: Hidrogênio: O Combustível da Transição Energética
Hidrogênio: O Combustível da Transição Energética Open
View article: Mannich Base Derived from Lawsone Inhibits PKM2 and Induces Neoplastic Cell Death
Mannich Base Derived from Lawsone Inhibits PKM2 and Induces Neoplastic Cell Death Open
Background/Objectives: Pyruvate kinase M2, a central regulator of cancer cell metabolism, has garnered significant attention as a promising target for disrupting the metabolic adaptability of tumor cells. This study explores the potential …
View article: Synthesis and evaluation of the activity of 1H-1,2,3-triazole-thiophene ester derivatives against Chikungunya virus
Synthesis and evaluation of the activity of 1H-1,2,3-triazole-thiophene ester derivatives against Chikungunya virus Open
View article: Ultrasound-assisted extraction of itraconazole from pellets: an efficient approach for the recovery of active pharmaceutical compounds from solid dosage forms
Ultrasound-assisted extraction of itraconazole from pellets: an efficient approach for the recovery of active pharmaceutical compounds from solid dosage forms Open
Introduction Itraconazole is a widely used broad-spectrum antifungal drug on a global scale. However, its poor water solubility necessitates the development of advanced formulations for its effective use. Currently, itraconazole is availab…
View article: New Chalcogen-Functionalized Naphthoquinones: Design, Synthesis, and Evaluation, <i>In Vitro</i> and <i>In Silico</i>, against Squamous Cell Carcinoma
New Chalcogen-Functionalized Naphthoquinones: Design, Synthesis, and Evaluation, <i>In Vitro</i> and <i>In Silico</i>, against Squamous Cell Carcinoma Open
Due to the growth in the number of patients and the complexity involved in anticancer therapies, new therapeutic approaches are urgent and necessary. In this context, compounds containing the selenium atom can be employed in developing new…
View article: The relationship of health with the sustainable development goals
The relationship of health with the sustainable development goals Open
By 2050 the planet will face several and complex challenges: feeding 9 billion people, creating homes for 2 billion new urban residents, providing universal access to health services, clean water, affordable and renewable energy, basic san…
View article: Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis
Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis Open
View article: Antimicrobial and wound healing potential of naphthoquinones encapsulated in nanochitosan
Antimicrobial and wound healing potential of naphthoquinones encapsulated in nanochitosan Open
Introduction: The use of chitosan in pharmaceutical formulations is an advantageous approach due to this compound intrinsic biodegradability and biocompatibility, as well as ready availability and low polymer cost. Methods: Herein, the nap…
View article: https://rvq.sbq.org.br/pdf/v16n4a07
https://rvq.sbq.org.br/pdf/v16n4a07 Open
View article: Aqui tem Quimica. Parte X. Consumo, Produção Responsável e Expectativas dos Objetivos do Desenvolvimento Sustentável
Aqui tem Quimica. Parte X. Consumo, Produção Responsável e Expectativas dos Objetivos do Desenvolvimento Sustentável Open
View article: Aqui tem Química Parte XII. A Água nas Instalações Sanitárias: Uso Eficiente e Sustentável
Aqui tem Química Parte XII. A Água nas Instalações Sanitárias: Uso Eficiente e Sustentável Open
View article: UM MÉTODO MAIS EFICIENTE DE ISOLAMENTO DO LAPACHOL DIRETAMENTE DA MATRIZ VEGETAL DO IPÊ
UM MÉTODO MAIS EFICIENTE DE ISOLAMENTO DO LAPACHOL DIRETAMENTE DA MATRIZ VEGETAL DO IPÊ Open
A MORE EFFICIENT METHOD OF ISOLATING LAPACHOL DIRECTLY FROM THE IPÊ VEGETABLE MATRIX. Lapachol, a naphthoquinone discovered in 1858, is a natural product with a broad spectrum of therapeutic activities, along with its derivatives and analo…
View article: Aqui tem Química XI. Rede de Saúde e Química Verde
Aqui tem Química XI. Rede de Saúde e Química Verde Open
View article: Aqui tem Química. Parte IX. Os Alcaloides das Florestas
Aqui tem Química. Parte IX. Os Alcaloides das Florestas Open
There is chemistry here is a series of articles that aims to show, in a didactic way, the importance of chemistry and its presence in all the materials and drugs we use on a daily basis.The most important natural products can only be obtai…
View article: Experimental and theoretical evaluation of the anticorrosive proprieties of new 1,2,3-triazolyl-acridine derivatives
Experimental and theoretical evaluation of the anticorrosive proprieties of new 1,2,3-triazolyl-acridine derivatives Open
Three novel 1,2,3-triazolyl-acridine derivatives (abbreviated as TTA, ATM, and ATA) were synthesized via a fast ultrasound-assisted copper-catalyzed azide-alkyne cycloaddition (CuAAC) in good yields. They were studied as corrosion inhibito…
View article: Aqui Tem Química: Parte VIII. Produtos Florestais não- Madeireiros (PFNM)
Aqui Tem Química: Parte VIII. Produtos Florestais não- Madeireiros (PFNM) Open
Forests represent the continuity of life on the planet and are the pillars of social and economic development.However, their existence is threatened due to the irresponsibility and greed of the humans who plunder their valuable natural res…
View article: Exploring the Antimicrobial and Antitumoral Activities of Naphthoquinone-Grafted Chitosans
Exploring the Antimicrobial and Antitumoral Activities of Naphthoquinone-Grafted Chitosans Open
Biopolymers obtained from natural macromolecules are noteworthy among materials presenting high biocompatibility and adequate biodegradability, as is the case of chitosan (CS), making this biopolymeric compound a suitable drug delivery sys…
View article: The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone
The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone Open
View article: Synthesis, Biological Evaluation and Molecular Modeling Studies of Naphthoquinone Sulfonamides and Sulfonate Ester Derivatives as P2X7 Inhibitors
Synthesis, Biological Evaluation and Molecular Modeling Studies of Naphthoquinone Sulfonamides and Sulfonate Ester Derivatives as P2X7 Inhibitors Open
ATP acts in the extracellular environment as an important signal, activating a family of receptors called purinergic receptors. In recent years, interest in the potential therapeutics of purinergic components, including agonists and antago…
View article: Synthesis and evaluation of photophysical, electrochemical, and ROS generation properties of new chalcogen-naphthoquinones-1,2,3-triazole hybrids
Synthesis and evaluation of photophysical, electrochemical, and ROS generation properties of new chalcogen-naphthoquinones-1,2,3-triazole hybrids Open
This study heralds an advancement in the synthesis of innovative hybrids with exceptional photophysical and electrochemical properties, promising advances in this area.