Explanipedia

LXR pathway drives hormonal response intensity in polycystic ovary syndrome Open

Sarah Dallel, Manon Despalles, Margaux Tore, Yoan Renaud, Ayhan Kocer , et al. · 2025

Loss of control of epithelial basal extrusion leads to tumor resistance in <i>Drosophila</i> Open

Cyrille de Joussineau, Marine Vialat, Elissa Baabdaty, Caroline Vachias, Françoise Degoul , et al. · 2025

Basal extrusion allows an epithelial cell to leave its compartment, making it a necessary step in the local invasion of all epithelial cancers. Here, we determined which effect sex steroid deprivation plays on basal extrusion, and the resu…

Liver X Receptors Enhance Epithelial to Mesenchymal Transition in Metastatic Prostate Cancer Cells Open

Erwan Bouchareb, Sarah Dallel, Angélique De Haze, Christelle Damon‐Soubeyrand, Yoan Renaud , et al. · 2024

Prostate cancer (PCa) is one of the most common cancers in men. Metastasis is the leading cause of death in prostate cancer patients. One of the crucial processes involved in metastatic spread is the “epithelial–mesenchymal transition” (EM…

Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis Open

Marine Vialat, Elissa Baabdaty, Amalia Trousson, Ayhan Kocer, Jean‐Marc A. Lobaccaro , et al. · 2024

Epidemiological studies point to cholesterol as a possible key factor for both prostate cancer incidence and progression. It could represent a targetable metabolite as the most aggressive tumors also appear to be sensitive to therapies des…

Cholesterol Dietary Intake and Tumour Cell Metabolism Drive Early Epithelial Tumorigenesis Open

Marine Vialat, Elissa Baabdaty, Amalia Trousson, Ayhan Kocer, Jean‐Marc A. Lobaccaro , et al. · 2024

Epidemiological studies point cholesterol as a possible key factor for both prostate cancer incidence and progression. So, it could represent a targetable metabolite as the most aggressive tumors also appear to be sensitive to therapies de…

Contribution of Sub-Saharan African medicinal plants to cancer research: Scientific basis 2013–2023 Open

Marc Donald Wilfried Adico, Bagora Bayala, Julio Buñay, Silvère Baron, Jacques Simporé , et al. · 2024

Cancer incidence and mortality rates are increasing worldwide. Cancer treatment remains a real challenge for African countries, especially in sub-Saharan Africa where funding and resources are very limited. High costs, side effects and dru…

Let’s talk about sex (steroids): Steroid deprivation promotes the emergence of a new resistant population in prostate-like Drosophila accessory gland Open

Marine Vialat, Amalia Trousson, Lobaccaro Jm, Silvère Baron, Laurence Morel , et al. · 2023

Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng from Burkina Faso, and Effects against Prostate and Cervical Cancer Cell Lines Open

Bagora Bayala, Laetizia Liz Coulibaly, Florencia Wendkuuni Djigma, Julio Buñay, Albert Théophane Yonli , et al. · 2023

The aim of this research was to evaluate the essential oil of Cymbopogon schoenanthus (L.) Spreng. (C. schoenanthus) from Burkina Faso in terms of cytotoxic activity against LNCaP cells, derived from prostate cancer, and HeLa cells, derive…

Modulation of wound healing regulators by thermal spring water from La Bourboule Open

Zangbéwendé Guy Ouedraogo, Allan Fouache, Amalia Trousson, James Jr Wilmo, Edith Filaire , et al. · 2023

Thermal spring waters have been a source of treatment for curing or alleviating symptoms of various pathologies. However, despite some supporting literature of the late 19 th century, there has been a gradual decrease in their use as the e…

Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng From Burkina Faso, and Effects Against Prostate and Cervical Cancer Cell Lines Open

Bagora Bayala, Laetizia Liz Coulibaly, Florencia Wendkuuni Djigma, Julio Buñay, Albert Théophane Yonli , et al. · 2023

The aim of this research was to evaluate the essential oil of Cymbopogon schoenanthus (L.) Spreng. (C. schoenanthus) from Burkina Faso in cytotoxic activity against LNCaP cells, derived from prostate cancer, and HeLa cells, derived from ce…

Harnessing the reverse cholesterol transport pathway to favor differentiation of monocyte-derived APCs and antitumor responses Open

Laura Raccosta, Maura Marinozzi, Susan Costantini, Daniela Maggioni, Lorena Maria Ferreira , et al. · 2023

Safety of Inulin and Sinistrin: Combining Several Sources for Pharmacovigilance Purposes Open

T-V. Bui, Caroline Prot‐Bertoye, H. Ayari, Silvère Baron, J-P. Bertocchio , et al. · 2021

Introduction: Inulin and its analog sinistrin are fructose polymers used in the food and pharmaceutical industries. In 2018, The French National Agency for the Safety of Medicines and Health Products (ANSM) decided to withdraw products con…

Mechanisms of epithelial mesenchymal transition by TGF-ß and LXRs in metastatic prostate cancer Open

E. Bouchareb, Julio Buñay, C. Gonthier, Lobaccaro Jm, Amalia Trousson , et al. · 2021

Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer Open

Amandine Rambur, Marine Vialat, Claude Beaudoin, Corinne Lours-Calet, Jean‐Marc A. Lobaccaro , et al. · 2021

Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease init…

MEN1 silencing aggravates tumorigenic potential of AR-independent prostate cancer cells through nuclear translocation and activation of JunD and β-catenin Open

Yakun Luo, Virginie Vlaeminck‐Guillem, Silvère Baron, Sarah Dallel, Chang Zhang , et al. · 2021

Background Recent studies highlighted the increased frequency of AR-low or -negative prostate cancers (PCas) and the importance of AR-independent mechanisms in driving metastatic castration-resistant PCa (mCRPC) development and progression…

Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia Open

Laura Bousset, Amandine Septier, Julio Buñay, Allison Voisin, Rachel Guiton , et al. · 2020

Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of ca…

Screening for liver X receptor modulators: Where are we and for what use? Open

Julio Buñay, Allan Fouache, Amalia Trousson, Cyrille de Joussineau, Erwan Bouchareb , et al. · 2020

Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are canonically activated by oxidized derivatives of cholesterol. Since the mid‐90s, numerous groups have identified LXRs as endocrine receptors that are involve…

Chemical Composition, Antioxidant and Cytotoxic Activities of Hyptis suaveolens (L.) Poit. Essential Oil on Prostate and Cervical Cancers Cells Open

Bagora Bayala, Christelle Nadembega, Samson Guenn eacu, Julio Buñ, Théodora Mahouk egr , et al. · 2020

This work help to justify some uses of H. suaveolens in traditional medicine in Burkina Faso and also, presents a promising new application for the essential oil of H. suaveolens in prostate and cervical cancer research.

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso Open

Bagora Bayala, Théodora Mahoukèdè Zohoncon, Florencia Wendkuuni Djigma, Christelle Nadembega, Silvère Baron , et al. · 2020

Medicinal plants are a potential source of drug discovery and development of cancer chemoprevention drugs. Thus, the aim of this work was to study the antioxidant and antiproliferative activities of hydromethanolic extracts of Musa sapient…

Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives Open

Bagora Bayala, Abdou Azaque Zouré, Silvère Baron, Cyrille de Joussineau, Jacques Simporé , et al. · 2020

The great majority of breast and prostate tumors are hormone-dependent cancers; hence, estrogens and androgens can, respectively, drive their developments, making it possible to use pharmacological therapies in their hormone-dependent phas…

Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila Open

Amandine Rambur, Corinne Lours-Calet, Claude Beaudoin, Julio Buñay, Marine Vialat , et al. · 2020

Chemical composition, antioxidant, anti-inflammatory and antiproliferative activities of the essential oil of Cymbopogon nardus, a plant used in traditional medicine Open

Bagora Bayala, Ahmed Yacouba Coulibaly, Florencia Wendkuuni Djigma, Bolni Marius Nagalo, Silvère Baron , et al. · 2020

Objectives Natural products commonly used in traditional medicine, such as essential oils (EOs), are attractive sources for the development of molecules with anti-proliferative activities for future treatment of human cancers, e.g., prosta…

Selective treatments of prostate tumor cells with a cold atmospheric plasma jet Open

Mohamed Fofana, Julio Buñay, Florian Judée, Silvère Baron, Sébastien Menecier , et al. · 2020

Effects of extracts and molecules derived from medicinal plants of West Africa in the prevention and treatment of gynecological cancers. A Review. Open

Bagora Bayala, Abdou Azaque Zouré, Théodora Mahoukèdè Zohoncon, Bienvenu L Tinguerie, Silvère Baron , et al. · 2020

Medicinal plants are a potential source of drug discovery and development of new pharmacological compounds for cancer chemoprevention. More than 80% of the West African population uses medicinal plants. It is estimated that over 60% of app…

New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors Open

Laura Bousset, Amandine Rambur, Allan Fouache, Julio Buñay, Laurent Morel , et al. · 2018

Prostate cancer (PCa) incidence has been dramatically increasing these last years in westernized countries. Though localized PCa is usually treated by radical prostatectomy, androgen deprivation therapy is preferred in locally advanced dis…

Liver X Receptors: A Possible Link between Lipid Disorders and Female Infertility Open

Sarah Dallel, Igor Tauveron, Florence Brugnon, Silvère Baron, Jean‐Marc A. Lobaccaro , et al. · 2018

A close relationship exists between cholesterol and female reproductive physiology. Indeed, cholesterol is crucial for steroid synthesis by ovary and placenta, and primordial for cell structure during folliculogenesis. Furthermore, oxyster…

Retraction Note: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer Open

Anthony Alioui, Julie Dufour, Valerio Leoni, Anke Loregger, Martina Moeton , et al. · 2018

This paper has been retracted at the request of the authors.

Dendrogenin A drives LXR to trigger lethal autophagy in cancers Open

Grégory Segala, Marion David, Philippe de Médina, Mathias C. Poirot, Nizar Serhan , et al. · 2017

Dendrogenin A (DDA) is a newly discovered cholesterol metabolite with tumor suppressor properties. Here, we explored its efficacy and mechanism of cell death in melanoma and acute myeloid leukemia (AML). We found that DDA induced lethal au…

RETRACTED ARTICLE: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer Open

Anthony Alioui, Julie Dufour, Valerio Leoni, Anke Loregger, Martina Moeton , et al. · 2017

The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate Open

Emmanuelle Martinot, Lauriane Sèdes, Marine Baptissart, Hélène Holota, Betty Rouaisnel , et al. · 2017

Silvère Baron YOU? Author Swipe