Silvia Cammarone
YOU?
Author Swipe
View article: Regulation of mitochondrial potassium BKCa channel by naringenin derivatives: application of a new cellular model
Regulation of mitochondrial potassium BKCa channel by naringenin derivatives: application of a new cellular model Open
Mitochondrial potassium (mitoK) channels play a crucial role in mitochondrial and cellular physiology. One of the best described mitoK channels is the mitochondrial large-conductance calcium-activated potassium (mitoBKCa) channel. It has b…
View article: Exploring the Chemical Composition and Antimicrobial Activity of Extracts from the Roots and Aboveground Parts of Limonium gmelini
Exploring the Chemical Composition and Antimicrobial Activity of Extracts from the Roots and Aboveground Parts of Limonium gmelini Open
Limonium gmelini (Willd.) Kuntze, a plant widely used in traditional medicine, has garnered increasing attention for its diverse pharmacological activities, including anti-inflammatory, hepatoprotective, antioxidant, and antimicrobial effe…
View article: Development of nanovehicles for co-delivery of colistin and ArnT inhibitors
Development of nanovehicles for co-delivery of colistin and ArnT inhibitors Open
View article: Exploration of the Aromatic Abietane Diterpenoid Scaffold in the Development of Arnt-Mediated Colistin Resistance Inhibitors
Exploration of the Aromatic Abietane Diterpenoid Scaffold in the Development of Arnt-Mediated Colistin Resistance Inhibitors Open
View article: Exploring the Potential of Anthraquinone‐Based Hybrids for Identifying a Novel Generation of Antagonists for the Smoothened Receptor in HH‐Dependent Tumour
Exploring the Potential of Anthraquinone‐Based Hybrids for Identifying a Novel Generation of Antagonists for the Smoothened Receptor in HH‐Dependent Tumour Open
Natural products (NPs) are highly profitable pharmacological tools due to their chemical diversity and ability to modulate biological systems. Accessing new chemical entities while retaining the biological relevance of natural chemotypes i…
View article: Resorc[4]arene Modifiers for Supramolecular Site‐Directed Immobilization of Antibodies on Multi‐Walled Carbon Nanotubes
Resorc[4]arene Modifiers for Supramolecular Site‐Directed Immobilization of Antibodies on Multi‐Walled Carbon Nanotubes Open
One of the main problems in developing immunosensors featuring carbon nanotubes (CNTs) is immobilizing antibodies (Abs) onto the CNT surface to afford selective binding to target antigens (Ags). In this work, we developed a practical supra…
View article: Resorc[4]arene-Modified Gold-Decorated Magnetic Nanoparticles for Immunosensor Development
Resorc[4]arene-Modified Gold-Decorated Magnetic Nanoparticles for Immunosensor Development Open
In recent years, several efforts have been made to develop selective, sensitive, fast response, and miniaturized immunosensors with improved performance for the monitoring and screening of analytes in several matrices, significantly expand…
View article: Natural Flavonoid Derivatives Have Pan-Coronavirus Antiviral Activity
Natural Flavonoid Derivatives Have Pan-Coronavirus Antiviral Activity Open
The SARS-CoV-2 protease (3CLpro) is one of the key targets for the development of efficacious drugs for COVID-19 treatment due to its essential role in the life cycle of the virus and exhibits high conservation among coronaviruses. Recent …
View article: Industrial Hemp (Cannabis sativa L.) Inflorescences as Novel Food: The Effect of Different Agronomical Practices on Chemical Profile
Industrial Hemp (Cannabis sativa L.) Inflorescences as Novel Food: The Effect of Different Agronomical Practices on Chemical Profile Open
In this study, the effect of several agronomical practices on the chemical composition of hemp inflorescences, a potential novel food that needs to be further studied, was observed. Here, the case study of inflorescences from Ferimon culti…
View article: A Route to Lipid ALC‐0315: a Key Component of a COVID‐19 mRNA Vaccine
A Route to Lipid ALC‐0315: a Key Component of a COVID‐19 mRNA Vaccine Open
This paper describes a synthesis of ALC‐0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent
View article: The Triprenylated Anthranoid Ferruginin A, a Promising Scaffold for the Development of Novel Antibiotics against Gram-Positive Bacteria
The Triprenylated Anthranoid Ferruginin A, a Promising Scaffold for the Development of Novel Antibiotics against Gram-Positive Bacteria Open
In today’s post-antibiotic era, the search for new antimicrobial compounds is of major importance and nature represents one of the primary sources of bioactive molecules. In this work, through a cheminformatics approach, we clustered an in…
View article: Identification of effective anticancer G-quadruplex-targeting chemotypes through the exploration of a high diversity library of natural compounds
Identification of effective anticancer G-quadruplex-targeting chemotypes through the exploration of a high diversity library of natural compounds Open
In the quest for selective G-quadruplex (G4)-targeting chemotypes, natural compounds have been thus far poorly explored, though representing appealing candidates due to the high structural diversity of their scaffolds. In this regard, a un…
View article: Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds
Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds Open
In the quest for selective G-quadruplex (G4)-targeting chemotypes, natural compounds have been thus far poorly explored, though representing appealing candidates due to the high structural diversity of their scaffolds. In this regard, a un…
View article: A Multimethodological Characterization of Cannabis sativa L. Inflorescences from Seven Dioecious Cultivars Grown in Italy: The Effect of Different Harvesting Stages
A Multimethodological Characterization of Cannabis sativa L. Inflorescences from Seven Dioecious Cultivars Grown in Italy: The Effect of Different Harvesting Stages Open
The chemical profile of the female inflorescence extracts from seven Cannabis sativa L. dioecious cultivars (Carmagnola, Fibranova, Eletta Campana, Antal, Tiborszallasi, Kompolti, and Tisza) was monitored at three harvesting stages (4, 14,…
View article: A unique high-diversity natural product collection as a reservoir of new therapeutic leads
A unique high-diversity natural product collection as a reservoir of new therapeutic leads Open
We review the successful application of computer-aided methods to screen a unique and high-diversity in house collection library composed of around 1000 individual natural products.
View article: <i>ent</i>-Beyerane Diterpenes as a Key Platform for the Development of ArnT-Mediated Colistin Resistance Inhibitors
<i>ent</i>-Beyerane Diterpenes as a Key Platform for the Development of ArnT-Mediated Colistin Resistance Inhibitors Open
Colistin is a last-resort antibiotic for the treatment of multidrug resistant Gram-negative bacterial infections. Recently, a natural ent-beyerene diterpene was identified as a promising inhibitor of the enzyme responsible for colis…
View article: The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections
The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections Open
The discovery of antibiotics has revolutionized the medicine and treatment of microbial infections. However, the current scenario has highlighted the difficulties in marketing new antibiotics and an exponential increase in the appearance o…