Silvia Christiansen
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View article: An integrated approach to molecular profiling supports precision diagnosis of pediatric medulloblastoma in Argentina amid the resource-constrained setting
An integrated approach to molecular profiling supports precision diagnosis of pediatric medulloblastoma in Argentina amid the resource-constrained setting Open
Medulloblastoma (MB) is the most common malignant pediatric brain tumor and shows marked molecular and clinical heterogeneity. Molecular subgrouping guides prognosis and treatment but remains scarce in low- and middle-income countries. We …
View article: Somatic mutational profiling and clinical impact of driver genes in Latin‐Iberian medulloblastomas: Towards precision medicine
Somatic mutational profiling and clinical impact of driver genes in Latin‐Iberian medulloblastomas: Towards precision medicine Open
Medulloblastoma (MB) is the most prevalent malignant brain tumor in children, known for its heterogeneity and treatment‐associated toxicity, and there is a critical need for new therapeutic targets. We analyzed the somatic mutation profile…
View article: WCN24-2435 CLINICAL CHARACTERISTICS OF PATIENTS WITH C3 GLOMERULOPATHY AND IDIOPATHIC MEMBRANOPROLIFERATIVE IMMUNE COMPLEX GLOMERULONEPHRITIS IN A HOSPITAL IN ARGENTINA
WCN24-2435 CLINICAL CHARACTERISTICS OF PATIENTS WITH C3 GLOMERULOPATHY AND IDIOPATHIC MEMBRANOPROLIFERATIVE IMMUNE COMPLEX GLOMERULONEPHRITIS IN A HOSPITAL IN ARGENTINA Open
Membranoproliferative glomerulonephritis (MPGN) is classified into 2 entities: immune complexes associated (IC-MPGN) and those mediated by C3 (C3G), according to immunofluorescence. A group of the first one are idiopathic. Both have simila…
View article: WCN24-2112 THE EFFECT OF AUTOPHAGY ON SENESCENCE DEVELOPMENT IN PROTOCOL BIOPSIES FROM KIDNEY TRANSPLANT PATIENTS
WCN24-2112 THE EFFECT OF AUTOPHAGY ON SENESCENCE DEVELOPMENT IN PROTOCOL BIOPSIES FROM KIDNEY TRANSPLANT PATIENTS Open
In kidney transplant, tissue expression of cyclin-dependent kinase inhibitors p16INK4a, a cellular senescence marker, is a strong predictor of poor allograft outcome. Autophagy is a tightly regulated cellular selfdegradation recycling proc…
View article: WCN24-2586 THE EFFECT OF BK VIRUS INFECTION ON KIDNEY GRAFT SURVIVAL, IN ISOLATED AND COMBINED RENAL TRANSPLANT AT THE HOSPITAL ITALIANO BUENOS AIRES
WCN24-2586 THE EFFECT OF BK VIRUS INFECTION ON KIDNEY GRAFT SURVIVAL, IN ISOLATED AND COMBINED RENAL TRANSPLANT AT THE HOSPITAL ITALIANO BUENOS AIRES Open
BK virus infection after kidney transplantation can negatively impact the prognosis of graft survival. BK nephropathy is an important cause of graft dysfunction and graft loss.Treatment options are limited, and in most cases require
View article: WCN24-2556 ACUTE HUMORAL REJECTION WITH AND WITHOUT DONOR SPECIFIC ANTI-HLA ANTIBODIES: CLINICAL AND HISTOLOGICAL CHARACTERISTICS IN KIDNEY TRANSPLANT PATIENTS
WCN24-2556 ACUTE HUMORAL REJECTION WITH AND WITHOUT DONOR SPECIFIC ANTI-HLA ANTIBODIES: CLINICAL AND HISTOLOGICAL CHARACTERISTICS IN KIDNEY TRANSPLANT PATIENTS Open
Antibody-mediated rejection (ABMR) is a significant cause of graft loss. The diagnosis of ABMR was historically made by three criteria: morphological evidence of acute tissue injury, presence of donor-specific antibodies (DSA), and C4d sta…
View article: WCN24-2570 CRYPTOCOCCOSIS IN KIDNEY TRANSPLANT RECIPIENTS BETWEEN 1988-2023, PREVALENCE AND CLINIC CHARACTERISTIC
WCN24-2570 CRYPTOCOCCOSIS IN KIDNEY TRANSPLANT RECIPIENTS BETWEEN 1988-2023, PREVALENCE AND CLINIC CHARACTERISTIC Open
Cryptococcosis is a frequent invasive fungal infection in solid organ transplant (SOT) recipients, being the third most frequent invasive mycosis. Worldwide prevalence is 5-10% and the incidence is 0.2 to 5%. The median time onset in all o…
View article: High frequency of WNT-activated medulloblastomas with CTNNB1 wild type suggests a higher proportion of hereditary cases in a Latin-Iberian population
High frequency of WNT-activated medulloblastomas with CTNNB1 wild type suggests a higher proportion of hereditary cases in a Latin-Iberian population Open
Purpose Medulloblastomas are the most common primary malignant brain tumors in children. They are divided into molecular subgroups: WNT-activated, SHH-Activated, TP53 mutant or wild type, and non-WNT/non-SHH (Groups 3 and 4). WNT-activated…
View article: Multidisciplinary approach to anaplastic and metastatic meningioma: A case report and review of the literature
Multidisciplinary approach to anaplastic and metastatic meningioma: A case report and review of the literature Open
Background: Meningiomas are slow-growing neoplasms, accounting for 20% of all primary intracranial neoplasms and 25% of all intraspinal tumors. Atypical and anaplastic meningiomas are infrequent, representing fewer than 5% of all meningiom…