Silvia Consalvi
YOU?
Author Swipe
View article: Duchenne Muscular Dystrophy: Integrating Current Clinical Practice with Future Therapeutic and Diagnostic Horizons
Duchenne Muscular Dystrophy: Integrating Current Clinical Practice with Future Therapeutic and Diagnostic Horizons Open
Duchenne muscular dystrophy (DMD) is a severe X-linked disorder characterized by progressive muscle degeneration due to mutations in the dystrophin gene. Despite major advancements in understanding its pathophysiology, there is still no cu…
View article: Duchenne Muscular Dystrophy: Integrating Current Clinical Practice with Future Therapeutic and Diagnostic Horizons
Duchenne Muscular Dystrophy: Integrating Current Clinical Practice with Future Therapeutic and Diagnostic Horizons Open
Duchenne Muscular Dystrophy (DMD) is a severe X-linked disorder characterized by progressive muscle degeneration due to mutations in the dystrophin gene. Despite major advancements in understanding its pathophysiology, there is still no cu…
View article: Synthesis of Novel Hyaluronic Acid Sulfonated Hydrogels Using Safe Reactants: A Chemical and Biological Characterization
Synthesis of Novel Hyaluronic Acid Sulfonated Hydrogels Using Safe Reactants: A Chemical and Biological Characterization Open
Here, we present a one-pot procedure for the preparation of hyaluronic acid (HA) sulfonated hydrogels in aqueous alkaline medium. The HA hydrogels were crosslinked using 1,4-butanedioldiglycidyl ether (BDDE) alone, or together with N-bis(2…
View article: Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro‐adipogenic progenitors
Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro‐adipogenic progenitors Open
View article: Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is associated to epigenetic and transcriptional features of cellular senescence
Partial resistance to HDAC inhibitors in FAPs of dystrophic muscles at late stages of disease is associated to epigenetic and transcriptional features of cellular senescence Open
Pharmacological treatment of Duchenne Muscular Dystrophy (DMD) with histone deacetylase inhibitors (HDACi) is currently being tested in clinical trials. Pre-clinical studies performed in mdx mice - the mouse model of DMD - have shown that …
View article: HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle‐resident mesenchymal cells
HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle‐resident mesenchymal cells Open
View article: Pharmacological tuning of microRNAs in FAP-derived Extracellular Vesicles by HDAC inhibitors promotes regeneration and reduces fibrosis in dystrophic muscles
Pharmacological tuning of microRNAs in FAP-derived Extracellular Vesicles by HDAC inhibitors promotes regeneration and reduces fibrosis in dystrophic muscles Open
Functional interactions between cellular components of the muscle stem cell (MuSC) niche regulate the regenerative ability of skeletal muscles in physiological and pathological conditions; however, the identity of the mediators of these in…
View article: Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy
Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy Open
View article: HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes
HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes Open
View article: Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation
Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation Open
View article: Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies
Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies Open
In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest. Therapeutic interventions that promote tissue and organ regeneration have as pri…
View article: HDAC inhibitors for muscular dystrophies: progress and prospects
HDAC inhibitors for muscular dystrophies: progress and prospects Open
HDAC inhibitors for muscular dystrophies: progress and prospects Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy (MD) that affects 1 in 3500–6000 live male bir…
View article: HDAC4 is necessary for satellite cell differentiation and muscle regeneration
HDAC4 is necessary for satellite cell differentiation and muscle regeneration Open
In response to injury, skeletal muscle exhibits high capacity to regenerate and epigenetics controls multiple steps of this process (Giordani et al., 2013). It has been demonstrated in vitro that completion of muscle differentiation requir…