Silvia Fabiano
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View article: Radiotherapy quality assurance in the PROTECT trial – a European randomised phase III-trial comparing proton and photon therapy in the treatment of patients with oesophageal cancer
Radiotherapy quality assurance in the PROTECT trial – a European randomised phase III-trial comparing proton and photon therapy in the treatment of patients with oesophageal cancer Open
Purpose: To present results from the trial radiotherapy quality assurance (RTQA) programme of the centres involved in the randomised phase-III PROton versus photon Therapy for esophageal Cancer – a Trimodality strategy (PROTECT)-trial, inv…
View article: Enhancing automated right‐sided early‐stage breast cancer treatments via deep learning model adaptation without additional training
Enhancing automated right‐sided early‐stage breast cancer treatments via deep learning model adaptation without additional training Open
Background Input data curation and model training are essential, but time‐consuming steps in building a deep‐learning (DL) auto‐planning model, ensuring high‐quality data and optimized performance. Ideally, one would prefer a DL model that…
View article: A new approach to combined proton-photon therapy for metastatic cancer patients
A new approach to combined proton-photon therapy for metastatic cancer patients Open
Objective. Proton therapy is a limited resource and is typically not available to metastatic cancer patients. Combined proton-photon therapy (CPPT), where most fractions are delivered with photons and only few with protons, represents an a…
View article: A novel stochastic optimization method for handling misalignments of proton and photon doses in combined treatments
A novel stochastic optimization method for handling misalignments of proton and photon doses in combined treatments Open
Objective. Combined proton–photon treatments, where most fractions are delivered with photons and only a few are delivered with protons, may represent a practical approach to optimally use limited proton resources. It has been shown that, …
View article: Combined proton–photon therapy for non‐small cell lung cancer
Combined proton–photon therapy for non‐small cell lung cancer Open
Purpose Advanced non‐small cell lung cancer (NSCLC) is still a challenging indication for conventional photon radiotherapy. Proton therapy has the potential to improve outcomes, but proton treatment slots remain a limited resource despite …
View article: A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy
A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy Open
Purpose In ultrahigh dose rate radiotherapy, the FLASH effect can lead to substantially reduced healthy tissue damage without affecting tumor control. Although many studies show promising results, the underlying biological mechanisms and t…
View article: Combined proton–photon treatment for breast cancer
Combined proton–photon treatment for breast cancer Open
Objective. Proton therapy remains a limited resource due to gantry size and its cost. Recently, a new design without a gantry has been suggested. It may enable combined proton–photon therapy (CPPT) in conventional bunkers and allow the wid…
View article: Stereotactic radiotherapy for early stage non-small cell lung cancer: current standards and ongoing research
Stereotactic radiotherapy for early stage non-small cell lung cancer: current standards and ongoing research Open
Stereotactic body radiation therapy (SBRT) allows for the non-invasive and precise delivery of ablative radiation dose. The use and availability of SBRT has increased rapidly over the past decades. SBRT has been proven to be a safe, effect…