Silvia Ippolito
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View article: Cholestyramine in Hyperthyroidism and Thyrotoxicosis: Have You Ever Used It?
Cholestyramine in Hyperthyroidism and Thyrotoxicosis: Have You Ever Used It? Open
Cholestyramine, a bile acid sequestrant, has been used primarily for lipid-lowering purposes but has also shown potential in managing hyperthyroidism and thyrotoxicosis. The objective of this review is to assess the efficacy, safety, and c…
View article: Kidney function in acromegaly: evidence from a long-term observational study
Kidney function in acromegaly: evidence from a long-term observational study Open
Purpose Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are critical regulators of renal development and function. Acromegaly, characterized by chronic GH hypersecretion, leads to renal hypertrophy and glomerular hyperfiltrati…
View article: Comparison of the night-time effectiveness in achieving glycemic targets in adults with type 1 diabetes of three advanced hybryd closed-loop systems
Comparison of the night-time effectiveness in achieving glycemic targets in adults with type 1 diabetes of three advanced hybryd closed-loop systems Open
View article: Elevated urine norepinephrine levels and alcohol use: A relationship that should be not neglected
Elevated urine norepinephrine levels and alcohol use: A relationship that should be not neglected Open
View article: Does denosumab exert a protective effect against COVID-19? Results of a large cohort study
Does denosumab exert a protective effect against COVID-19? Results of a large cohort study Open
Introduction Denosumab is a monoclonal antibody blocking the receptor activator of nuclear factor kappa-B/receptor activator of nuclear factor kappa-B ligand (RANK/RANKL) pathway, thus inhibiting osteoclastogenesis. Since RANK and RANKL ar…
View article: Cardioprotective Effects of Sodium Glucose Cotransporter 2 Inhibition in Angiotensin II-Dependent Hypertension Are Mediated by the Local Reduction of Sympathetic Activity and Inflammation
Cardioprotective Effects of Sodium Glucose Cotransporter 2 Inhibition in Angiotensin II-Dependent Hypertension Are Mediated by the Local Reduction of Sympathetic Activity and Inflammation Open
The cardioprotective effects of sodium glucose cotrasponter 2 (SGLT2) inhibitors seem to be independent from the effects on glycemic control, through little-known mechanisms. In this study, we investigate whether the cardioprotective effec…
View article: Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study
Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study Open
Introduction Thyroid dysfunctions associated with SARS-CoV-2 acute infection have been extensively described since the beginning of COVID-19 pandemics. Conversely, few data are available on the occurrence of thyroid autoimmunity after COVI…
View article: Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life-DATASET
Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life-DATASET Open
Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life dataset
View article: Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life-DATASET
Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life-DATASET Open
Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life dataset
View article: Angiotensin II Modulates Calcium/Phosphate Excretion in Experimental Model of Hypertension: Focus on Bone
Angiotensin II Modulates Calcium/Phosphate Excretion in Experimental Model of Hypertension: Focus on Bone Open
A link between hypertension and long-term bone health has been suggested. The aim of this study was to investigate the effects of chronic angiotensin II administration on urinary calcium/phosphate excretion, bone mineral density, bone remo…
View article: The Old and the New in Subacute Thyroiditis: An Integrative Review
The Old and the New in Subacute Thyroiditis: An Integrative Review Open
Subacute thyroiditis (SAT) is the most common cause of neck pain and thyrotoxicosis. Although this disease was recognized already by the end of the 18th century, new concepts regarding pathogenesis have emerged in recent years. Moreover, i…
View article: Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life
Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life Open
Purpose Current treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients’ quality of life (QoL) is of paramount importance, especially motor disability and depres…
View article: Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life
Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life Open
Purpose Current treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients’ quality of life (QoL) is of paramount importance, especially motor disability and depres…
View article: SARS-CoV-2 vaccine-associated subacute thyroiditis: insights from a systematic review
SARS-CoV-2 vaccine-associated subacute thyroiditis: insights from a systematic review Open
View article: SARS-CoV-2 detection in primary thyroid sarcoma: coincidence or interaction?
SARS-CoV-2 detection in primary thyroid sarcoma: coincidence or interaction? Open
View article: Angiotensin Type 2 and Mas Receptor Activation Prevents Myocardial Fibrosis and Hypertrophy through the Reduction of Inflammatory Cell Infiltration and Local Sympathetic Activity in Angiotensin II-Dependent Hypertension
Angiotensin Type 2 and Mas Receptor Activation Prevents Myocardial Fibrosis and Hypertrophy through the Reduction of Inflammatory Cell Infiltration and Local Sympathetic Activity in Angiotensin II-Dependent Hypertension Open
Compound 21 (C21), an AT2 receptor agonist, and Angiotensin 1-7 (Ang 1-7), through Mas receptor, play an important role in the modulation of the protective arm of the renin-angiotensin system. The aim of this study was to investigate in an…
View article: Distinct Cytokine Signatures in Thyroiditis Induced by PD-1 or CTLA-4 Blockade: Insights from a New Mouse Model
Distinct Cytokine Signatures in Thyroiditis Induced by PD-1 or CTLA-4 Blockade: Insights from a New Mouse Model Open
Background: The pathogenesis of thyroiditis caused by immune-checkpoint inhibitors (ICIs) such as antiprogrammed death receptor-1 (PD-1) and anticytotoxic T lymphocyte antigen-4 (CTLA-4) is incompletely understood. To gain me…
View article: Sodium-glucose cotransporter 2 inhibition prevents renal fibrosis in cyclosporine nephropathy
Sodium-glucose cotransporter 2 inhibition prevents renal fibrosis in cyclosporine nephropathy Open
View article: Change in newly diagnosed Graves’ disease phenotype between the twentieth and the twenty-first centuries: meta-analysis and meta-regression
Change in newly diagnosed Graves’ disease phenotype between the twentieth and the twenty-first centuries: meta-analysis and meta-regression Open
Purpose According to a few recent studies, the clinical phenotype of Graves’ disease (GD) at onset is becoming milder in recent years, in terms of prevalence and severity of hyperthyroidism, goiter and overt eye disease. The aim of this st…
View article: SARS-CoV-2: a potential trigger for subacute thyroiditis? Insights from a case report
SARS-CoV-2: a potential trigger for subacute thyroiditis? Insights from a case report Open
View article: Gastric Xanthomatous Hyperplastic Polyps – Just an Incidental Endoscopic Finding?
Gastric Xanthomatous Hyperplastic Polyps – Just an Incidental Endoscopic Finding? Open
Background: Laparoscopic sleeve gastrectomy (LSG) progressively became the preferred procedure worldwide for the treatment of morbid obesity. Occasionally, unknown gastrointestinal diseases may be incidentally discovered during the procedu…
View article: Hypophysitis induced by immune checkpoint inhibitors: a 10-year assessment
Hypophysitis induced by immune checkpoint inhibitors: a 10-year assessment Open
Introduction: Hypophysitis caused by immune checkpoint inhibitors (ICIs) has risen to the medical attention during the past decade. ICIs are monoclonal antibodies that block the interaction between molecules that normally inhibit th…
View article: Multidisciplinary Management of Intrathoracic Goiter: A Case Report
Multidisciplinary Management of Intrathoracic Goiter: A Case Report Open
Introduction: Intrathoracic goiters are associated with compression of nearby structures, triggering severe compressive symptoms. Total thyroidectomy is the gold standard to treat these cases. Case Presentation: A patient with a huge intra…
View article: Impaired testicular signaling of vitamin A and vitamin K contributes to the aberrant composition of the extracellular matrix in idiopathic germ cell aplasia
Impaired testicular signaling of vitamin A and vitamin K contributes to the aberrant composition of the extracellular matrix in idiopathic germ cell aplasia Open
View article: Hypophysitis induced by immune checkpoint inhibitors: a 10-year assessment
Hypophysitis induced by immune checkpoint inhibitors: a 10-year assessment Open
Introduction: Hypophysitis caused by immune checkpoint inhibitors (ICIs) has risen to the medical attention during the past decade. ICIs are monoclonal antibodies that block the interaction between molecules that normally inhibit th…
View article: Testicular microbiome in azoospermic men—first evidence of the impact of an altered microenvironment
Testicular microbiome in azoospermic men—first evidence of the impact of an altered microenvironment Open
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View article: Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?
Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role? Open
Objective The aim of this observational study was to clarify the link between vitamin D status and metabolic syndrome (MetS) in people with visceral obesity. Design and methods One hundred ninety-six consecutive patients (152 women; mean a…
View article: Primary, secondary and compensated hypogonadism: a novel risk stratification for infertile men
Primary, secondary and compensated hypogonadism: a novel risk stratification for infertile men Open
Summary Recently, the cohort of men from the European Male Ageing Study has been stratified into different categories distinguishing primary, secondary and compensated hypogonadism. A similar classification has not yet been applied to the …
View article: Low Birth Weight Is Associated with a Decreased Overall Adult Health Status and Reproductive Capability – Results of a Cross-Sectional Study in Primary Infertile Patients
Low Birth Weight Is Associated with a Decreased Overall Adult Health Status and Reproductive Capability – Results of a Cross-Sectional Study in Primary Infertile Patients Open
Individuals born with low birth weight (LBW) risk cardiometabolic complications later in life. However the impact of LBW on general health status and male reproductive function has been scantly analysed. We investigated the clinical and se…
View article: Validation of the American Society for Reproductive Medicine guidelines/recommendations in white European men presenting for couple's infertility
Validation of the American Society for Reproductive Medicine guidelines/recommendations in white European men presenting for couple's infertility Open