Silvia Lang
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View article: Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease
Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease Open
The involvement of the intestinal microbiome in the pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC), is well-established. Bacteria interact with immune cells at sites of intestinal inflammation, but also in the…
View article: Roseburia intestinalis Modulates Immune Responses by Inducing M1 Macrophage Polarization
Roseburia intestinalis Modulates Immune Responses by Inducing M1 Macrophage Polarization Open
In recent years, the gut microbiome has been recognized as one influential factor in cancer development. Particularly in colorectal cancer (CRC), several studies observed a major imbalance of the intestinal microbiota, marked by a reductio…
View article: Intestinal epithelial PTPN23 is essential for gut barrier integrity and prevention of fatal bacterial translocation
Intestinal epithelial PTPN23 is essential for gut barrier integrity and prevention of fatal bacterial translocation Open
Background and Aims Protein tyrosine phosphatase nonreceptor type 23 (PTPN23) regulates the internalization of growth factor receptors such as the epithelial growth factor receptor (EGFR). Given the crucial function of such receptors in in…
View article: Synthetic GPR84 Agonists in Colorectal Cancer: Effective in THP-1 Cells but Ineffective in BMDMs and MC38 Mouse Tumor Models
Synthetic GPR84 Agonists in Colorectal Cancer: Effective in THP-1 Cells but Ineffective in BMDMs and MC38 Mouse Tumor Models Open
Tumor-associated macrophages (TAMs) in the colorectal cancer (CRC) microenvironment promote tumor progression but can be reprogrammed into a pro-inflammatory state with anti-cancer properties. Activation of the G protein-coupled receptor 8…
View article: Impact of Nanoplastic Particles on Macrophage Inflammation and Intestinal Health in a Mouse Model of Inflammatory Bowel Disease
Impact of Nanoplastic Particles on Macrophage Inflammation and Intestinal Health in a Mouse Model of Inflammatory Bowel Disease Open
Background: The increasing presence of plastics in the human diet is raising public concern about the potential risks posed by nanoplastic (NP) particles, which can emerge from the degradation of plastic debris. NP ingestion poses particul…
View article: Application of CRISPR/Cas9 in Wheat Genetic Improvement
Application of CRISPR/Cas9 in Wheat Genetic Improvement Open
View article: NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22 Open
The authors recently became aware of errors in Figure 8, A and B. In Figure 8A, the WT/H 2 O and WT/DSS pictures were inadvertently switched.In Figure 8B, the incorrect image was shown for the Ptpn22 -/-/DSS sample.The correct figure is sh…
View article: Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity
Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity Open
Our work shows that GP96 plays a fundamental role in regulating ISC fate and epithelial regeneration and therefore is indispensable for maintaining intestinal epithelial homeostasis.
View article: Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer
Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer Open
Background Integrin αvβ6 is a heterodimeric cell surface protein whose cellular expression is determined by the availability of the integrin β6 subunit (ITGB6). It is expressed at very low levels in most organs during tissue homeostasis bu…
View article: pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis
pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis Open
Local extracellular acidification occurs at sites of inflammation. Proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1, also known as GPR68) responds to decreases in extracellular pH. Our previous studies show a role for OGR1 …
View article: MMP9 expression in intestinal fistula from patients with fistulizing CD and from human xenograft mouse model
MMP9 expression in intestinal fistula from patients with fistulizing CD and from human xenograft mouse model Open
Fistula treatment represents a major unmet medical need in the therapy of Crohn's disease (CD). Current medical therapies, such as anti-TNF antibody treatments, are often insufficient and do not achieve permanent fistula closure. Previousl…
View article: Efficient treatment of esophageal nutrition bezoars: dissolution outmatches removal—the Zurich approach
Efficient treatment of esophageal nutrition bezoars: dissolution outmatches removal—the Zurich approach Open
Enteral feed bezoars are difficult to treat and can lead to serious adverse events. There is no standardized treatment approach and various strategies have been suggested. We herein describe three cases of successful dissolutions of feed b…
View article: Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis
Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis Open
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) plays a critical role in the pathogenesis of inflammatory bowel diseases (IBD). Mice lacking PTPN2 in dendritic cells (DCs) develop skin and liver inflammation by the age of 22 weeks …
View article: Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells
Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells Open
Environmental and genetic factors have been demonstrated to contribute to the development of inflammatory bowel disease (IBD). Recent studies suggested that the food additive; titanium dioxide (TiO2) might play a causative role in the dise…
View article: A Novel OGR1 (GPR68) Inhibitor Attenuates Inflammation in Murine Models of Colitis
A Novel OGR1 (GPR68) Inhibitor Attenuates Inflammation in Murine Models of Colitis Open
Background and Aims: Local extracellular acidification is associated with several conditions, such as ischemia, cancer, metabolic disease, respiratory diseases, and inflammatory bowel disease (IBD). Several recent studies rep…
View article: Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa
Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa Open
Introduction: Intestinal fibrosis, characterized by excessive deposition of extracellular matrix proteins, is a common and severe clinical complication of inflammatory bowel disease (IBD). However, the mechanisms underlying f…
View article: Contribution of CD3+CD8- and CD3+CD8+ T Cells to TNF-<i>α</i> Overexpression in Crohn Disease–Associated Perianal Fistulas and Induction of Epithelial-Mesenchymal Transition in HT-29 Cells
Contribution of CD3+CD8- and CD3+CD8+ T Cells to TNF-<i>α</i> Overexpression in Crohn Disease–Associated Perianal Fistulas and Induction of Epithelial-Mesenchymal Transition in HT-29 Cells Open
Background Fistulas represent a frequent and severe complication in patients with Crohn disease (CD). Tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta, and interleukin (IL)-13 are known to trigger epithelial-mesenchymal…
View article: Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development
Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development Open
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) recently emerged as a promising cancer immunotherapy target. We set out to investigate the functional role of PTPN2 in the pathogenesis of human colorectal carcinoma (CRC), as its rol…
View article: Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance
Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance Open
Protein tyrosine phosphatase non-receptor type 2 (PTPN2) plays a pivotal role in immune homeostasis and has been associated with human autoimmune and chronic inflammatory diseases. Though PTPN2 is well-characterized in lymphocytes, little …
View article: Protein Tyrosine Phosphatase Nonreceptor Type 2 Expression Does Not Correlate with Viral Load or Response to Direct-Acting Antiviral Therapy in Hepatitis C Virus Infections-Infected Patients
Protein Tyrosine Phosphatase Nonreceptor Type 2 Expression Does Not Correlate with Viral Load or Response to Direct-Acting Antiviral Therapy in Hepatitis C Virus Infections-Infected Patients Open
Background/Aims: The hepatitis C virus nonstructural 3/4A protease has been shown to cleave protein tyrosine phosphatase nonreceptor type 2 (PTPN2, also known as T cell protein tyrosine phosphatase), thereby inducing a shift from a Th1 tow…
View article: Presence of PTPN2 SNP rs1893217 Enhances the Anti-inflammatory Effect of Spermidine
Presence of PTPN2 SNP rs1893217 Enhances the Anti-inflammatory Effect of Spermidine Open
Background The single nucleotide polymorphism (SNP) rs1893217 within the gene locus encoding PTPN2 represents a risk factor for inflammatory bowel disease (IBD). Our previous work demonstrated reduced PTPN2 activity and subsequently increa…
View article: Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis
Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis Open
Fecal microbiota transfer (FMT) is a very efficient approach for the treatment of severe and recurring C. difficile infections. However, the beneficial effect of FMT in other disorders such as ulcerative colitis (UC) or Crohn's disease rem…
View article: Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner
Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner Open
The gut microbiota is crucial for our health, and well-balanced interactions between the host's immune system and the microbiota are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). A …
View article: Mo1922 – Supplementation with Butyrate Producing Bacteria Reduces Tumor Load in a Mouse Model of Crc
Mo1922 – Supplementation with Butyrate Producing Bacteria Reduces Tumor Load in a Mouse Model of Crc Open
View article: The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis
The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis Open
The gene encoding for Epstein-Barr virus-induced G-protein-coupled receptor 2 (EBI2) is a risk gene for inflammatory bowel disease (IBD). Together with its oxysterol ligand 7α,25-dihydroxycholesterol, EBI2 mediates migration and differenti…
View article: DOP02 Supplementation with butyrate producing bacteria reduces tumour load in a mouse model of colitis-associated cancer
DOP02 Supplementation with butyrate producing bacteria reduces tumour load in a mouse model of colitis-associated cancer Open
Colorectal carcinoma is still a severe complication in patients with long-standing and severe ulcerative colitis. Current guidelines suggest that surgical total proctocolectomy must be considered in patients with high-grade dysplasia. Phar…
View article: P052 Heat shock protein GP96 is essential for maintaining intestinal epithelial architecture by supporting its self-renewal capacity
P052 Heat shock protein GP96 is essential for maintaining intestinal epithelial architecture by supporting its self-renewal capacity Open
The intestinal epithelium is characterised by a remarkable self-renewal capacity and a high turnover of intestinal epithelial cells (IEC), which emerge from intestinal stem cells (ISC). Defects in proliferation and differentiation of ISC i…
View article: β<sub>6</sub>‐integrin serves as a novel serum tumor marker for colorectal carcinoma
β<sub>6</sub>‐integrin serves as a novel serum tumor marker for colorectal carcinoma Open
Colorectal cancer (CRC) is one of the leading causes of cancer‐related deaths worldwide and the need for novel biomarkers and therapeutic strategies to improve diagnosis and surveillance is obvious. This study aims to identify β 6 ‐integri…
View article: The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation
The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation Open
View article: Deletion of Protein Tyrosine Phosphatase Nonreceptor Type 2 in Intestinal Epithelial Cells Results in Upregulation of the Related Phosphatase Protein Tyrosine Phosphatase Nonreceptor Type 23
Deletion of Protein Tyrosine Phosphatase Nonreceptor Type 2 in Intestinal Epithelial Cells Results in Upregulation of the Related Phosphatase Protein Tyrosine Phosphatase Nonreceptor Type 23 Open
Background/Aims: Knockdown of protein tyrosine phosphatase nonreceptor type 2 (PTPN2) exaggerates IFN-γ-induced intestinal barrier defects, but mice constitutively lacking PTPN2 in epithelial cells (PTPN2xVilCre…