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View article: X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes
X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes Open
The sequence diversity of natural and laboratory populations of Brugia pahangi and Brugia malayi was assessed with Illumina resequencing followed by mapping to identify single nucleotide variants and insertions/deletions. In natural and la…
View article: X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes
X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes Open
The sequence diversity of natural and laboratory populations of Brugia pahangi and Brugia malayi was assessed with Illumina resequencing followed by mapping in order to identify single nucleotide variants and insertions/deletions. In natur…
View article: Dual RNAseq analyses at soma and germline levels reveal evolutionary innovations in the elephantiasis-agent Brugia malayi, and adaptation of its Wolbachia endosymbionts
Dual RNAseq analyses at soma and germline levels reveal evolutionary innovations in the elephantiasis-agent Brugia malayi, and adaptation of its Wolbachia endosymbionts Open
Brugia malayi is a human filarial nematode responsible for elephantiasis, a debilitating condition that is part of a broader spectrum of diseases called filariasis, including lymphatic filariasis and river blindness. Almost all filarial ne…
View article: Complete Genome Sequence of <i>w</i> Bp, the <i>Wolbachia</i> Endosymbiont of Brugia pahangi FR3
Complete Genome Sequence of <i>w</i> Bp, the <i>Wolbachia</i> Endosymbiont of Brugia pahangi FR3 Open
Lymphatic filariasis is a devastating disease caused by filarial nematode roundworms, which contain obligate Wolbachia endosymbionts. Here, we assembled the genome of w Bp, the Wolbachia endosymbiont of the filarial nematode Brugia pahangi…
View article: Nearly Complete Genome Sequence of Brugia pahangi FR3
Nearly Complete Genome Sequence of Brugia pahangi FR3 Open
Brugia pahangi is a zoonotic parasite that is closely related to human-infecting filarial nematodes. Here, we report the nearly complete genome of Brugia pahangi , including assemblies of four autosomes and an X chromosome, with only seven…
View article: Nearly Complete Genome Sequence of Brugia malayi Strain FR3
Nearly Complete Genome Sequence of Brugia malayi Strain FR3 Open
Lymphatic filariasis affects ∼120 million people and can result in elephantiasis and hydrocele. Here, we report the nearly complete genome sequence of the best-studied causative agent of lymphatic filariasis, Brugia malayi . The assembly c…
View article: Sex chromosome evolution in parasitic nematodes of humans
Sex chromosome evolution in parasitic nematodes of humans Open
Sex determination mechanisms often differ even between related species yet the evolution of sex chromosomes remains poorly understood in all but a few model organisms. Some nematodes such as Caenorhabditis elegans have an XO sex determinat…
View article: Drug Repurposing of Bromodomain Inhibitors as Potential Novel Therapeutic Leads for Lymphatic Filariasis Guided by Multispecies Transcriptomics
Drug Repurposing of Bromodomain Inhibitors as Potential Novel Therapeutic Leads for Lymphatic Filariasis Guided by Multispecies Transcriptomics Open
The current treatment regimen for lymphatic filariasis is mostly microfilaricidal. In an effort to identify new drug candidates for lymphatic filariasis, we conducted a three-way transcriptomics/systems biology study of one of the causativ…
View article: Multispecies Transcriptomics Data Set of Brugia malayi, Its <i>Wolbachia</i> Endosymbiont <i>w</i> Bm, and Aedes aegypti across the B. malayi Life Cycle
Multispecies Transcriptomics Data Set of Brugia malayi, Its <i>Wolbachia</i> Endosymbiont <i>w</i> Bm, and Aedes aegypti across the B. malayi Life Cycle Open
Here, we present a comprehensive transcriptomics data set of Brugia malayi , its Wolbachia endosymbiont w Bm, and its vector host. This study samples from 16 stages across the entire B. malayi life cycle, including stage 1 through 4 larvae…
View article: Targeted enrichment outperforms other enrichment techniques and enables more multi-species RNA-Seq analyses
Targeted enrichment outperforms other enrichment techniques and enables more multi-species RNA-Seq analyses Open
Enrichment methodologies enable analysis of minor members in multi-species transcriptomic analyses. We compared standard enrichment of bacterial and eukaryotic mRNA to targeted enrichment with Agilent SureSelect (AgSS) capture for Brugia m…
View article: Visualizing Bacterial Colony Morphologies Using Time-Lapse Imaging Chamber MOCHA
Visualizing Bacterial Colony Morphologies Using Time-Lapse Imaging Chamber MOCHA Open
Capturing microbial growth on a macroscopic scale is of great importance to further our understanding of microbial life. However, methods for imaging microbial life on a scale of millimeters to centimeters are often limited by designs that…
View article: Genetic Signature of Resistance to White Band Disease in the Caribbean Staghorn Coral Acropora cervicornis
Genetic Signature of Resistance to White Band Disease in the Caribbean Staghorn Coral Acropora cervicornis Open
Coral reefs are declining worldwide due to multiple factors including rising sea surface temperature, ocean acidification, and disease outbreaks. Over the last 30 years, White Band Disease (WBD) alone has killed up to 95% of the Caribbean`…