Silvia Lucía Cuffini
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View article: First Step into Praziquantel Raw Material Color Change Investigation: The Role of Thermal, Spectroscopic, and Microscopic Techniques
First Step into Praziquantel Raw Material Color Change Investigation: The Role of Thermal, Spectroscopic, and Microscopic Techniques Open
Praziquantel (PZQ) is an anthelmintic agent used worldwide for the treatment of schistosomiasis. PZQ is used as a racemate, and it is practically insoluble in water. The PZQ racemate is a white to nearly white crystalline powder, and few s…
View article: Controlling crystallisation with audible low frequency sound
Controlling crystallisation with audible low frequency sound Open
We show that low-frequency audible sound drives the crystallisation of distinct solid forms of organic compounds in solution crystallisation.
View article: Design and development of raw clay-based formulations emulsions loaded with ascorbyl glucoside, <i>in vitro</i> evaluations on topical delivery and cell viability
Design and development of raw clay-based formulations emulsions loaded with ascorbyl glucoside, <i>in vitro</i> evaluations on topical delivery and cell viability Open
Clays are layered materials with several unique features, which lead to many useful applications for natural products. In particular, raw clay has been increasingly utilized in skin care products and major advances have been achieved in th…
View article: Eutectic Mixtures Containing the Active Pharmaceutical Ingredient Ezetimibe: Phase Diagrams, Solid State Characterization and Dissolution Profiles
Eutectic Mixtures Containing the Active Pharmaceutical Ingredient Ezetimibe: Phase Diagrams, Solid State Characterization and Dissolution Profiles Open
View article: CCDC 2108341: Experimental Crystal Structure Determination
CCDC 2108341: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Combining modified CCDC tools to predict multicomponent formation: co-crystals of nevirapine and benzoic derivatives
Combining modified CCDC tools to predict multicomponent formation: co-crystals of nevirapine and benzoic derivatives Open
XXV General Assembly and Congress of the International Union of Crystallography - (IUCr 2021). Prague, Czech Republic, 14-22 August 2021. .-https://journals.iucr.org/a/issues/2021/a2/00/
View article: CCDC 2012055: Experimental Crystal Structure Determination
CCDC 2012055: Experimental Crystal Structure Determination Open
View article: CCDC 2012054: Experimental Crystal Structure Determination
CCDC 2012054: Experimental Crystal Structure Determination Open
View article: CCDC 2012053: Experimental Crystal Structure Determination
CCDC 2012053: Experimental Crystal Structure Determination Open
View article: CCDC 1964383: Experimental Crystal Structure Determination
CCDC 1964383: Experimental Crystal Structure Determination Open
View article: CCDC 1941056: Experimental Crystal Structure Determination
CCDC 1941056: Experimental Crystal Structure Determination Open
View article: CCDC 1941057: Experimental Crystal Structure Determination
CCDC 1941057: Experimental Crystal Structure Determination Open
View article: Optimization and comparison of statistical tools for the prediction of multicomponent forms of a molecule: the antiretroviral nevirapine as a case study
Optimization and comparison of statistical tools for the prediction of multicomponent forms of a molecule: the antiretroviral nevirapine as a case study Open
A methodology is proposed to assess the propensity to obtain multicomponent forms of an API based on the combination of modified statistical analytical tools to order the possible co-formers in a ranking index.
View article: Irbesartan desmotropes: Solid-state characterization, thermodynamic study and dissolution properties
Irbesartan desmotropes: Solid-state characterization, thermodynamic study and dissolution properties Open
Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the solid-state, both tautom…
View article: Drug Solubility Enhancement through the Preparation of Multicomponent Organic Materials: Eutectics of Lovastatin with Carboxylic Acids
Drug Solubility Enhancement through the Preparation of Multicomponent Organic Materials: Eutectics of Lovastatin with Carboxylic Acids Open
Lovastatin (LOV) is a drug used to treat hypercholesterolemia. Recent studies have identified its antioxidant effects and potential use in the treatment of some types of cancer. However, the low bioavailability related to its poor water so…
View article: X-ray diffraction, vibrational and thermal study of dibenzazepinodione, a pharmacopeial impurity of oxcarbazepine
X-ray diffraction, vibrational and thermal study of dibenzazepinodione, a pharmacopeial impurity of oxcarbazepine Open
View article: CCDC 1557942: Experimental Crystal Structure Determination
CCDC 1557942: Experimental Crystal Structure Determination Open
View article: The effect of solution environment and the electrostatic factor on the crystallisation of desmotropes of irbesartan
The effect of solution environment and the electrostatic factor on the crystallisation of desmotropes of irbesartan Open
The experimental conditions necessary for stabilising irbesartan (IBS) tautomers in solution and selectively obtaining the desmotropic crystal forms are presented herein.
View article: Challenging identification of polymorphic mixture: Polymorphs I, II and III in olanzapine raw materials
Challenging identification of polymorphic mixture: Polymorphs I, II and III in olanzapine raw materials Open
View article: Irbesartan crystal forms: thermodynamic and dissolution properties study
Irbesartan crystal forms: thermodynamic and dissolution properties study Open
Irbesartan is an anti-hypertensive drug practically insoluble in water and belongs to class II of the BCS.Solubility is a key factor in anti-hypertensive drugs because a rapid onset and increased extent of bioavailability after administrat…
View article: Clay minerals: Properties and applications to dermocosmetic products and perspectives of natural raw materials for therapeutic purposes—A review
Clay minerals: Properties and applications to dermocosmetic products and perspectives of natural raw materials for therapeutic purposes—A review Open
View article: Influence of ethylcellulose—Medium chain triglycerides blend on the flow behavior and β-V polymorph retention of dark chocolate
Influence of ethylcellulose—Medium chain triglycerides blend on the flow behavior and β-V polymorph retention of dark chocolate Open
View article: Cocristais: uma estratégia promissora na área farmacêutica
Cocristais: uma estratégia promissora na área farmacêutica Open
Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magni…
View article: CCDC 838928: Experimental Crystal Structure Determination
CCDC 838928: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts
Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts Open
View article: CCDC 1401779: Experimental Crystal Structure Determination
CCDC 1401779: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1401782: Experimental Crystal Structure Determination
CCDC 1401782: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1401780: Experimental Crystal Structure Determination
CCDC 1401780: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1401781: Experimental Crystal Structure Determination
CCDC 1401781: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …