Silvia M. Uriarte
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View article: Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen
Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen Open
Endogenous pathogens can constrain virulence to ensure survival in the host. Pathogenic state can be controlled by metabolic responses to the prevailing microenvironment; however, the coupling and effector mechanisms are not well understoo…
View article: <i>Yersinia pestis</i>actively inhibits the production of extracellular vesicles by human neutrophils
<i>Yersinia pestis</i>actively inhibits the production of extracellular vesicles by human neutrophils Open
Yersinia pestis is the etiologic agent of the plague. A hallmark of plague is subversion of the host immune response by disrupting host signaling pathways required for inflammation. This non-inflammatory environment permits bacterial colon…
View article: Distinct Mechanisms of Type 3 Secretion System Recognition Control LTB<sub>4</sub>Synthesis in Neutrophils versus Macrophages
Distinct Mechanisms of Type 3 Secretion System Recognition Control LTB<sub>4</sub>Synthesis in Neutrophils versus Macrophages Open
Leukotriene B4 (LTB 4 ) is critical for initiating the inflammatory cascade in response to infection. However, Yersinia pestis colonizes the host by inhibiting the timely synthesis of LTB 4 and inflammation. Here, we show that the bacteria…
View article: Inhibition of type III secretion system induced leukotriene B<sub>4</sub>production by<i>Yersinia pestis</i>: A mechanism for early immune evasion
Inhibition of type III secretion system induced leukotriene B<sub>4</sub>production by<i>Yersinia pestis</i>: A mechanism for early immune evasion Open
Subverting the host immune response to inhibit inflammation is a key virulence factor of Yersinia pestis . The inflammatory cascade is tightly controlled via the sequential action of lipid and protein mediators of inflammation. Because del…
View article: Differential Functional Responses of Neutrophil Subsets in Severe COVID-19 Patients
Differential Functional Responses of Neutrophil Subsets in Severe COVID-19 Patients Open
Neutrophils play a significant role in determining disease severity following SARS-CoV-2 infection. Gene and protein expression defines several neutrophil clusters in COVID-19, including the emergence of low density neutrophils (LDN) that …
View article: The Hunger Games: Aggregatibacter actinomycetemcomitans Exploits Human Neutrophils As an Epinephrine Source for Survival
The Hunger Games: Aggregatibacter actinomycetemcomitans Exploits Human Neutrophils As an Epinephrine Source for Survival Open
Aggregatibacter actinomycetemcomitans is a gram-negative facultative anaerobe and an opportunistic oral pathogen, strongly associated with periodontitis and other inflammatory diseases. Periodontitis is a chronic inflammation of the period…
View article: Periodontal Pathogens’ strategies disarm neutrophils to promote dysregulated inflammation
Periodontal Pathogens’ strategies disarm neutrophils to promote dysregulated inflammation Open
Periodontitis is an irreversible, chronic inflammatory disease where inflammophilic pathogenic microbial communities accumulate in the gingival crevice. Neutrophils are a major component of the innate host response against bacterial challe…
View article: Human Neutrophil Granule Exocytosis in Response to Mycobacterium smegmatis
Human Neutrophil Granule Exocytosis in Response to Mycobacterium smegmatis Open
Mycobacterium smegmatis rarely causes disease in the immunocompetent, but reported cases of soft tissue infection describe abscess formation requiring surgical debridement for resolution. Neutrophils are the first innate immune cells to ac…
View article: TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling
TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling Open
View article: Human neutrophils depend on extrinsic factors produced by monocytes for their survival response to TLR4 stimulation
Human neutrophils depend on extrinsic factors produced by monocytes for their survival response to TLR4 stimulation Open
LPS delays neutrophil apoptosis by a process generally assumed to involve cell-intrinsic TLR4 signaling. However, neutrophil survival responses to LPS have been reported to be monocyte-dependent, which would indicate more complexity than i…
View article: Issue Information
Issue Information Open
HTLV-1 infection modulates cytotoxicity molecules, cell proliferation, IFN- production on T lymphocytes, suggesting that these lymphocytes are involved in pathogenesis of HTLV-1 infection.
View article: <i>Filifactor alocis</i> manipulates human neutrophils affecting their ability to release neutrophil extracellular traps induced by PMA
<i>Filifactor alocis</i> manipulates human neutrophils affecting their ability to release neutrophil extracellular traps induced by PMA Open
Neutrophils operate at the site of injury or inflammation in the periodontal pocket to ensure periodontal health and clearance of bacterial pathogens. Filifactor alocis is recently identified as a potential periodontal pathogen, and in thi…
View article: Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica–Induced Sterile Inflammation
Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica–Induced Sterile Inflammation Open
Silicosis is a lung inflammatory disease caused by chronic exposure to crystalline silica (CS). Leukotriene B4 (LTB4) plays an important role in neutrophilic inflammation, which drives silicosis and promotes lung cancer. In this study, we …
View article: Multiple Phenotypic Changes Define Neutrophil Priming
Multiple Phenotypic Changes Define Neutrophil Priming Open
Exposure to pro-inflammatory cytokines, chemokines, mitochondrial contents, and bacterial and viral products induces neutrophils to transition from a basal state into a primed one, which is currently defined as an enhanced response to acti…
View article: Neutrophil function in elderly patients hospitalized with community-acquired pneumonia.
Neutrophil function in elderly patients hospitalized with community-acquired pneumonia. Open
Background: Advanced age is associated with immunosenescence as well as increased risk for poor outcomes during episodes of community-acquired pneumonia (CAP). Data on neutrophil function in hospitalized elderly patients with CAP is lackin…
View article: Resolvin D1, resolvin D2 and maresin 1 activate the GSK3β anti-inflammatory axis in TLR4-engaged human monocytes
Resolvin D1, resolvin D2 and maresin 1 activate the GSK3β anti-inflammatory axis in TLR4-engaged human monocytes Open
Pro-resolving, docosahexaenoic acid-derived mediators have recently emerged as important potential therapeutic agents for the amelioration of complications arising from inflammation, such as vascular disease, asthma, acute lung injury and …
View article: Lower Respiratory Tract Infection of the Ferret by 2009 H1N1 Pandemic Influenza A Virus Triggers Biphasic, Systemic, and Local Recruitment of Neutrophils
Lower Respiratory Tract Infection of the Ferret by 2009 H1N1 Pandemic Influenza A Virus Triggers Biphasic, Systemic, and Local Recruitment of Neutrophils Open
Infection of the lower respiratory tract by influenza A viruses results in increases in inflammation and immune cell infiltration in the lung. The dynamic relationships among the lung microenvironments, the lung, and systemic host response…