Silvia Panetti
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View article: Novel H-2D<sup>b</sup>-restricted CD8 epitope derived from mouse MAGE-type antigen P1A mediates antitumor immunity in C57BL/6 mice
Novel H-2D<sup>b</sup>-restricted CD8 epitope derived from mouse MAGE-type antigen P1A mediates antitumor immunity in C57BL/6 mice Open
Background Melanoma antigen gene (MAGE)-type antigens are promising targets for cancer immunotherapy as they are expressed in cancer cells but not in normal tissues, except for male germline cells. The mouse P1A antigen shares this MAGE-ty…
View article: Chemotherapy synergizes with cancer vaccines and expands stem-like TCF1+CD8+ T cells
Chemotherapy synergizes with cancer vaccines and expands stem-like TCF1+CD8+ T cells Open
Summary Therapeutic cancer vaccines, whether based on neoantigens or shared antigens, will likely be given in the clinic together with the standard of care, which often comprises immune checkpoint blockade therapy and chemotherapy. It rema…
View article: Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment
Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment Open
Cancer cells take up amino acids from the extracellular space to drive cell proliferation and viability. Similar mechanisms are applied by immune cells, resulting in the competition between conventional T cells, or indeed chimeric antigen …
View article: Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity
Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity Open
Hematological and solid cancers catabolize the semiessential amino acid arginine to drive cell proliferation. However, the resulting low arginine microenvironment also impairs chimeric antigen receptor T cells (CAR-T) cell proliferation, l…
View article: Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation
Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation Open
Linking immunometabolic adaptation to T-cell function provides insight for the development of new therapeutic approaches in multiple disease settings. T-cell activation and downstream effector functions of CD4+ and CD8+ T-cells are control…