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View article: A multifunctional anti-O-Antigen human monoclonal antibody protects against <i>Shigella sonnei</i> infection in vivo
A multifunctional anti-O-Antigen human monoclonal antibody protects against <i>Shigella sonnei</i> infection in vivo Open
Shigellosis is a global public health challenge that mostly affects low- and middle-income countries and causes considerable morbidity and mortality among children under 5 y of age. Multi- and extensively drug-resistant Shigella sonnei str…
View article: The Synergetic Effect of Periodontal Therapy and <scp>TNF</scp>‐α Inhibitor for the Treatment of Comorbid Periodontitis and Psoriasis
The Synergetic Effect of Periodontal Therapy and <span>TNF</span>‐α Inhibitor for the Treatment of Comorbid Periodontitis and Psoriasis Open
Aim To assess the adjunctive effect of periodontal therapy on psoriasis‐related outcomes in a combined experimental model of ligature‐induced periodontitis and Imiquimod (IMQ)‐induced psoriasis. Also, this experiment aimed to study the imp…
View article: GMMA decorated with mucin 1 Tn/STn mimetics elicit specific antibodies response and inhibit tumor growth
GMMA decorated with mucin 1 Tn/STn mimetics elicit specific antibodies response and inhibit tumor growth Open
View article: Robust and cost‐effective CRISPR/Cas9 gene editing of primary tumor B cells in Eµ‐TCL1 model of chronic lymphocytic leukemia
Robust and cost‐effective CRISPR/Cas9 gene editing of primary tumor B cells in Eµ‐TCL1 model of chronic lymphocytic leukemia Open
View article: Are periodontitis and psoriasis associated? A pre‐clinical murine model
Are periodontitis and psoriasis associated? A pre‐clinical murine model Open
Aim To investigate the bidirectional influence between periodontitis and psoriasis, using the respective experimental models of ligature‐ and imiquimod‐induced diseases on murine models. Materials and Methods Thirty‐two C57/BL6J mice were …
View article: Anti-Tumor Efficacy of In Situ Vaccination Using Bacterial Outer Membrane Vesicles
Anti-Tumor Efficacy of In Situ Vaccination Using Bacterial Outer Membrane Vesicles Open
In situ vaccination (ISV) is a promising cancer immunotherapy strategy that consists of the intratumoral administration of immunostimulatory molecules (adjuvants). The rationale is that tumor antigens are abundant at the tumor site, and th…
View article: Anti-tumor Efficacy of<i>in situ</i>Vaccination Using Bacterial Outer Membrane Vesicles
Anti-tumor Efficacy of<i>in situ</i>Vaccination Using Bacterial Outer Membrane Vesicles Open
In situ vaccination (ISV) is a promising cancer immunotherapy strategy, consists in the intratumoral administration of immunostimulatory molecules (adjuvants). The rationale is that tumor antigens are abundant at the tumor site and therefo…
View article: Supplementary Figure 2 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 2 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 32K, Effects of different compound AXIN stabilizers on TNKS1 and TNKS2.
View article: Supplementary Figure 6 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 6 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 112K, Average body weight graph.
View article: Supplementary Figure Legend from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure Legend from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 81K
View article: Data from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Data from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
Glioblastoma multiforme (GBM) is the most common and prognostically unfavorable form of brain tumor. The aggressive and highly invasive phenotype of these tumors makes them among the most anatomically damaging human cancers with a median s…
View article: Supplementary Figure Legend from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure Legend from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 81K
View article: Supplementary Figure 1 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 1 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 94K, Consequences of inhibition of WNT signaling in glioblastoma cells: a less proliferative and less tumorigenic phenotype.
View article: Supplementary Figure 4 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 4 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 10K, SEN461 affects canonical WNT ligands mediated transcription.
View article: Supplementary Figure 2 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 2 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 32K, Effects of different compound AXIN stabilizers on TNKS1 and TNKS2.
View article: Supplementary Figure 3 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 3 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 20K, Comparative WNT transcriptional activity and growth inhibition with different compound AXIN stabilizers.
View article: Supplementary Figure 5 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 5 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 98K, In vitro response of T98G cells to WNT signaling inhibition.
View article: Data from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Data from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
Glioblastoma multiforme (GBM) is the most common and prognostically unfavorable form of brain tumor. The aggressive and highly invasive phenotype of these tumors makes them among the most anatomically damaging human cancers with a median s…
View article: Supplementary Figure 1 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 1 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 94K, Consequences of inhibition of WNT signaling in glioblastoma cells: a less proliferative and less tumorigenic phenotype.
View article: Supplementary Figure 4 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 4 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 10K, SEN461 affects canonical WNT ligands mediated transcription.
View article: Supplementary Figure 3 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 3 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 20K, Comparative WNT transcriptional activity and growth inhibition with different compound AXIN stabilizers.
View article: Supplementary Figure 6 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 6 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 112K, Average body weight graph.
View article: Supplementary Figure 5 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells
Supplementary Figure 5 from Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells Open
PDF file - 98K, In vitro response of T98G cells to WNT signaling inhibition.
View article: Outer Membrane Vesicles From The Gut Microbiome Contribute to Tumor Immunity by Eliciting Cross-Reactive T Cells
Outer Membrane Vesicles From The Gut Microbiome Contribute to Tumor Immunity by Eliciting Cross-Reactive T Cells Open
A growing body of evidence supports the notion that the gut microbiome plays an important role in cancer immunity. However, the underpinning mechanisms remain to be fully elucidated. One attractive hypothesis envisages that among the T cel…
View article: Outer Membrane Vesicles from the gut microbiome contribute to tumor immunity by eliciting cross-reactive T cells
Outer Membrane Vesicles from the gut microbiome contribute to tumor immunity by eliciting cross-reactive T cells Open
The gut microbiome plays a key role in cancer immunity. One proposed mechanism is through the elicitation of T cells, which incidentally recognize neo-epitopes arising from cancer mutations (“molecular mimicry (MM)” hypothesis). To support…
View article: Proteome‐minimized outer membrane vesicles from <i>Escherichia coli</i> as a generalized vaccine platform
Proteome‐minimized outer membrane vesicles from <i>Escherichia coli</i> as a generalized vaccine platform Open
Because of their potent adjuvanticity, ease of manipulation and simplicity of production Gram‐negative Outer Membrane Vesicles OMVs have the potential to become a highly effective vaccine platform. However, some optimization is required, i…
View article: Bacterial outer membrane vesicles engineered with lipidated antigens as a platform for <i>Staphylococcus aureus</i> vaccine
Bacterial outer membrane vesicles engineered with lipidated antigens as a platform for <i>Staphylococcus aureus</i> vaccine Open
Significance Thanks to their potent built-in adjuvanticity, bacterial outer membrane vesicles (OMVs) represent an attractive vaccine platform. However, their full-blown exploitation relies on the availability of efficient engineering strat…
View article: Vaccination With a FAT1-Derived B Cell Epitope Combined With Tumor-Specific B and T Cell Epitopes Elicits Additive Protection in Cancer Mouse Models
Vaccination With a FAT1-Derived B Cell Epitope Combined With Tumor-Specific B and T Cell Epitopes Elicits Additive Protection in Cancer Mouse Models Open
Human FAT1 is overexpressed on the surface of most colorectal cancers (CRCs) and in particular a 25 amino acid sequence (D8) present in one of the 34 cadherin extracellular repeats carries the epitope recognized by mAb198.3, a monoclonal a…
View article: Structure–activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway
Structure–activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway Open