Silvia Vega-Rubín-de-Celis
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View article: Autophagy suppression via SRC induction represents a therapeutic vulnerability for <i>BAP1</i> -mutant cancers
Autophagy suppression via SRC induction represents a therapeutic vulnerability for <i>BAP1</i> -mutant cancers Open
BAP1 is a tumor suppressor and epigenetic modifier that is frequently mutated in cancer, leading to increased aggressiveness and metastasis, as well as poor patient survival. Unfortunately, there are currently no specific therapies for met…
View article: Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma
Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma Open
The KIT/c-KIT proto-oncogene is frequently over-expressed in Merkel cell carcinoma (MCC), an aggressive skin cancer commonly caused by Merkel cell polyomavirus (MCPyV). Here, we demonstrated that truncated MCPyV-encoded large T-antigen (LT…
View article: GRB2, a protein known for a long time with a new autophagy-regulating function
GRB2, a protein known for a long time with a new autophagy-regulating function Open
BECN1 (BCL2 interacting myosin like coiled protein) is a major regulator of autophagy and a haploinsufficient tumor suppressor. BECN1 binds to multiple proteins and it is part of at least two different class III phosphatidylinositol (PI) 3…
View article: GRB2 is a BECN1 interacting protein that regulates autophagy
GRB2 is a BECN1 interacting protein that regulates autophagy Open
GRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated with BECN1 in several breast cancer cell lines and regulates autophagy…
View article: Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective
Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective Open
With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanis…
View article: Editorial: Molecular Mechanisms of Autophagy in Cancer
Editorial: Molecular Mechanisms of Autophagy in Cancer Open
EDITORIAL article Front. Cell Dev. Biol., 17 June 2022Sec. Molecular and Cellular Pathology https://doi.org/10.3389/fcell.2022.918511
View article: Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM Cells
Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM Cells Open
Malignant pleural mesothelioma (MPM) is a rare type of cancer with a grim prognosis. So far, no targetable oncogenic mutation was identified in MPM and biomarkers with predictive value toward drug sensitivity or resistance are also lacking…
View article: A Dual HiBiT-GFP-LC3 Lentiviral Reporter for Autophagy Flux Assessment
A Dual HiBiT-GFP-LC3 Lentiviral Reporter for Autophagy Flux Assessment Open
Autophagy is an intracellular degradation process that maintains the cellular homeostasis and it is regulated in multiple ways, both in health and disease. Assessment of autophagic flux in cells is an important approach for understanding t…
View article: Studying Autophagy In Vivo in the Mammary Gland and in Xenograft Samples
Studying Autophagy In Vivo in the Mammary Gland and in Xenograft Samples Open
Autophagy is a dynamic process that can be monitored in multiple ways, both in vitro and in vivo. Studies in mice are a widely used tool to understand multiple diseases and conditions where autophagy plays a role, and therefore autophagic …
View article: Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown
Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown Open
Cancer bioenergetics fuel processes necessary to maintain viability and growth under stress conditions. We hypothesized that cancer metabolism supports the repair of radiation-induced DNA double-stranded breaks (DSBs). We combined the syst…
View article: Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma
Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma Open
Depending on context and tumor stage, deregulation of autophagy can either suppress tumorigenesis or promote chemoresistance and tumor survival. Histone deacetylases (HDACs) can modulate autophagy; however, the exact mechanisms are not ful…
View article: Abrogating <scp>GPT2</scp> in triple‐negative breast cancer inhibits tumor growth and promotes autophagy
Abrogating <span>GPT2</span> in triple‐negative breast cancer inhibits tumor growth and promotes autophagy Open
Uncontrolled proliferation and altered metabolic reprogramming are hallmarks of cancer. Active glycolysis and glutaminolysis are characteristic features of these hallmarks and required for tumorigenesis. A fine balance between cancer metab…
View article: Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases
Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases Open
Beclin 1 is a major regulator of autophagy, and it is a core component of the class III PI3K complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number of ways, including post-translational modifications. S…
View article: The Role of Beclin 1-Dependent Autophagy in Cancer
The Role of Beclin 1-Dependent Autophagy in Cancer Open
Autophagy (self-eating) is an intracellular degradation process used by cells to keep a “clean house”; as it degrades abnormal or damaged proteins and organelles, it helps to fight infections and also provides energy in times of fasting or…
View article: 19 Autophagy induction as a new therapy for HER2+ breast tumorigenesis
19 Autophagy induction as a new therapy for HER2+ breast tumorigenesis Open
Introduction HER2 is a receptor tyrosine kinase whose gene is amplified in ~20% human breast cancer patients. Allelic loss of the autophagy gene, beclin 1/BECN1, is associated with HER2 amplification in breast cancer; low beclin 1 mRNA ex…
View article: Increased autophagy blocks HER2-mediated breast tumorigenesis
Increased autophagy blocks HER2-mediated breast tumorigenesis Open
Significance Approximately 20% of breast cancers have amplification of a cancer-causing signaling molecule known as human epidermal growth factor receptor 2 (HER2). Decreased mRNA expression of the autophagy gene, beclin 1/BECN1 , increase…
View article: Multistep regulation of TFEB by MTORC1
Multistep regulation of TFEB by MTORC1 Open
The master regulator of lysosome biogenesis, TFEB, is regulated by MTORC1 through phosphorylation at S211, and a S211A mutation increases nuclear localization. However, TFEBS211A localizes diffusely in both cytoplasm and nucleus and, as we…