Silviana Lee
YOU?
Author Swipe
View article: RAD51 is chromatin enriched and targetable in BRCA1-deficient cells
RAD51 is chromatin enriched and targetable in BRCA1-deficient cells Open
BRCA1 mutant cancers are homologous recombination (HR) deficient, and their sensitivity to anti-cancer therapies such as poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) has long been attributed to this defect. Accordingly, the HR ma…
View article: FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells
FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells Open
The effectiveness of poly (ADP-ribose) polymerase inhibitors (PARPi) in creating single-stranded DNA gaps and inducing sensitivity requires the FANCJ DNA helicase. Yet, how FANCJ relates to PARP1 inhibition or trapping, which contribute to…
View article: FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells
FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells Open
SUMMARY Single-stranded DNA gaps are postulated to be fundamental to the mechanism of anti-cancer drugs. Gaining insights into their induction could therefore be pivotal for advancing therapeutic strategies. For poly (ADP-ribose) polymeras…
View article: Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection <i>In</i> <i>Vitro</i> and in a Mouse Model
Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection <i>In</i> <i>Vitro</i> and in a Mouse Model Open
The relationship between serial infections of two different serotypes of dengue virus and more severe disease courses is well-documented in the literature, driven by so-called antibody-dependent enhancement (ADE). Recently, studies have sh…