Silvie R. Ruigrok
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View article: Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro
Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro Open
In Alzheimer’s disease, microglial phagocytosis is engaged in the pathogenesis as it clears abnormal protein accumulations, debris, and apoptotic cells in the early stages of Alzheimer’s disease, but fuels neuroinflammation and accelerates…
View article: Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing
Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing Open
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, and late-life depression, such that altered HN could rep…
View article: Powering the social brain: Mitochondria in social behaviour
Powering the social brain: Mitochondria in social behaviour Open
A central role of brain mitochondria in regulating and influencing social behaviour is emerging. In addition to its important roles as the "powerhouses" of the cell, mitochondria possess a plethora of cellular functions, such as regulating…
View article: Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons
Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons Open
The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut–brain axis, signal to the brain and influence cognition. Human studies have so far had limited success in identifying early metabolic alterati…
View article: Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study
Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study Open
View article: Sex-dependence and comorbidities of the early-life adversity induced mental and metabolic disease risks: Where are we at?
Sex-dependence and comorbidities of the early-life adversity induced mental and metabolic disease risks: Where are we at? Open
View article: Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline
Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline Open
View article: Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12‐Year Prospective Study
Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12‐Year Prospective Study Open
Scope Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent. Methods and Results The article studies the long‐term prospective Three‐Cit…
View article: The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia
The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia Open
Introduction Diet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise‐triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. These factors m…
View article: Modulation of the Hypothalamic Nutrient Sensing Pathways by Sex and Early-Life Stress
Modulation of the Hypothalamic Nutrient Sensing Pathways by Sex and Early-Life Stress Open
There are sex differences in metabolic disease risk, and early-life stress (ES) increases the risk to develop such diseases, potentially in a sex-specific manner. It remains to be understood, however, how sex and ES affect such metabolic v…
View article: Effects of early-life stress on peripheral and central mitochondria in male mice across ages
Effects of early-life stress on peripheral and central mitochondria in male mice across ages Open
Exposure to early-life stress (ES) increases the vulnerability to develop metabolic diseases as well as cognitive dysfunction, but the specific biological underpinning of the ES-induced programming is unknown. Metabolic and cognitive disor…
View article: Adult food choices depend on sex and exposure to early-life stress: Underlying brain circuitry, adipose tissue adaptations and metabolic responses
Adult food choices depend on sex and exposure to early-life stress: Underlying brain circuitry, adipose tissue adaptations and metabolic responses Open
View article: Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study
Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: A case-control analysis nested within the Three-City cohort study Open
View article: Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers
Effects of Early-Life Stress, Postnatal Diet Modulation and Long-Term Western-Style Diet on Peripheral and Central Inflammatory Markers Open
Early-life stress (ES) exposure increases the risk of developing obesity. Breastfeeding can markedly decrease this risk, and it is thought that the physical properties of the lipid droplets in human milk contribute to this benefit. A conce…
View article: Caffeine Compromises Proliferation of Human Hippocampal Progenitor Cells
Caffeine Compromises Proliferation of Human Hippocampal Progenitor Cells Open
The age-associated reduction in the proliferation of neural stem cells (NSCs) has been associated with cognitive decline. Numerous factors have been shown to modulate this process, including dietary components. Frequent consumption of caff…
View article: Increasing availability of ω‐3 fatty acid in the early‐life diet prevents the early‐life stress‐induced cognitive impairments without affecting metabolic alterations
Increasing availability of ω‐3 fatty acid in the early‐life diet prevents the early‐life stress‐induced cognitive impairments without affecting metabolic alterations Open
Exposure to early‐life stress (ES) is associated with cognitive and metabolic deficits in adulthood. The role of early nutrition in programming these long‐term effects is largely unknown. We focused on essential ω‐3 and ω‐6 long‐chain poly…
View article: Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats
Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats Open
Endothelial cell–stabilizing drugs reverse white matter pathology in a rat model of cerebral small vessel disease.
View article: The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis
The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis Open
View article: Ghrelin and hypothalamic NPY/AgRP expression in mice are affected by chronic early-life stress exposure in a sex-specific manner
Ghrelin and hypothalamic NPY/AgRP expression in mice are affected by chronic early-life stress exposure in a sex-specific manner Open
View article: Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation
Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation Open
View article: Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer’s disease mouse model
Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer’s disease mouse model Open
View article: Neuroinflammation is not a Prerequisite for Diabetes-induced Tau Phosphorylation
Neuroinflammation is not a Prerequisite for Diabetes-induced Tau Phosphorylation Open
Abnormal phosphorylation and aggregation of tau is a key hallmark of Alzheimer's disease (AD). AD is a multifactorial neurodegenerative disorder for which Diabetes Mellitus (DM) is a risk factor. In animal models for DM, the phosphorylatio…