Silvin P. Knight
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View article: The association between STOPPFall medication use and falls and fractures in community-dwelling older people
The association between STOPPFall medication use and falls and fractures in community-dwelling older people Open
Background Falls and fractures are common among older people. The Screening Tool of Older Persons Prescriptions in older adults with high fall risk (STOPPFall) provides a comprehensive list of fall-risk-increasing drugs (FRIDs). This study…
View article: Assessing the Skeletal Muscle Pump During Lower Limb Counterpressure: Lags and Causality in Cardiovascular Regulation
Assessing the Skeletal Muscle Pump During Lower Limb Counterpressure: Lags and Causality in Cardiovascular Regulation Open
Background Orthostatic hypotension (OH) is a prevalent condition among older adults, characterised by a sudden drop in blood pressure upon standing, often leading to dizziness and increased risk of falls, morbidity and mortality. The skele…
View article: Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes
Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes Open
Introduction There is a critical link between vascular disease and the progression to dementia. The hippocampus has been implicated in memory and cognitive decline. In this study, we investigate the independent and moderating effects of in…
View article: The association between STOPPFall medication use and falls and fractures in community-dwelling older people
The association between STOPPFall medication use and falls and fractures in community-dwelling older people Open
Introduction Falls and fractures are common among older people. The Screening Tool of Older Persons Prescriptions in older adults with high fall risk (STOPPFall) provides a comprehensive list of fall-risk-increasing drugs (FRIDs). This stu…
View article: Connecting the dots: microstructural properties of white matter hyperintensities predict longitudinal cognitive changes in ageing
Connecting the dots: microstructural properties of white matter hyperintensities predict longitudinal cognitive changes in ageing Open
This study investigates the relationship between white matter hyperintensities (WMHs) and longitudinal cognitive decline in older adults. Using data from The Irish Longitudinal Study on Ageing (TILDA), we examined WMH characteristics, incl…
View article: Regional changes in cerebral perfusion with age when accounting for changes in gray‐matter volume
Regional changes in cerebral perfusion with age when accounting for changes in gray‐matter volume Open
Purpose One possible contributing factor for cerebral blood flow (CBF) decline in normal aging is the increase in partial volume effects due to brain atrophy, as cortical thinning can exacerbate the contamination of gray‐matter (GM) voxels…
View article: Relationship Between Lifestyle Factors and Accelerometery Based Motion Capture Analysis During An Active Stand In Healthy Older Adults
Relationship Between Lifestyle Factors and Accelerometery Based Motion Capture Analysis During An Active Stand In Healthy Older Adults Open
Background One in three individuals aged over 65 and one in two individuals over 80 experience falls in a year. As the population ages, preventing balance issues and falls among healthy older adults becomes increasingly critical. As the po…
View article: Investigating Skeletal Muscle Pump Function Using Thigh EMG, Thigh NIRS, And Stroke Volume Data In The FRAILMatics Physiological Cohort
Investigating Skeletal Muscle Pump Function Using Thigh EMG, Thigh NIRS, And Stroke Volume Data In The FRAILMatics Physiological Cohort Open
Background The pioneering female physiologist Frances Hellebrandt first highlighted the significance of the skeletal muscle pump in circulation in the 1930s. However, the mechanisms underlying the muscle pump's function remain elusive, par…
View article: Existing and Emerging Measures of Muscle Strength and Mass in the Assessment of Sarcopenia
Existing and Emerging Measures of Muscle Strength and Mass in the Assessment of Sarcopenia Open
Background Sarcopenia, an accelerated loss of muscle strength and mass is a major driver of adverse health outcomes in older people. The European Working Group on Sarcopenia recommends muscle strength assessment with handgrip strength (HGS…
View article: Cardiovascular Autonomic Function and Progression of Age-Related Macular Degeneration in The Irish Longitudinal Study of Ageing (TILDA)
Cardiovascular Autonomic Function and Progression of Age-Related Macular Degeneration in The Irish Longitudinal Study of Ageing (TILDA) Open
These observational data suggest that impaired hemodynamic responses within the first 20 seconds of orthostasis may be associated with the progression of AMD.
View article: White matter fibre density in the brain's inhibitory control network is associated with falling in older adults
White matter fibre density in the brain's inhibitory control network is associated with falling in older adults Open
Recent research has indicated that the relationship between age-related cognitive decline and falling may be mediated by the individual’s capacity to quickly cancel or inhibit a motor response. This longitudinal investigation demonstrates …
View article: White matter fibre density in the brain's inhibitory control network is associated with falling in low activity older adults
White matter fibre density in the brain's inhibitory control network is associated with falling in low activity older adults Open
Recent research has indicated that the relationship between age‐related cognitive decline and falling may be mediated by the individual's capacity to quickly cancel or inhibit a motor response. This longitudinal investigation demonstrates …
View article: Were Frailty Identification Criteria Created Equal? A Comparative Case Study on Continuous Non-Invasively Collected Neurocardiovascular Signals during an Active Standing Test in the Irish Longitudinal Study on Ageing (TILDA)
Were Frailty Identification Criteria Created Equal? A Comparative Case Study on Continuous Non-Invasively Collected Neurocardiovascular Signals during an Active Standing Test in the Irish Longitudinal Study on Ageing (TILDA) Open
Background: In this observational study, we compared continuous physiological signals during an active standing test in adults aged 50 years and over, characterised as frail by three different criteria, using data from The Irish Longitudin…
View article: Slower speed of blood pressure recovery after standing is associated with accelerated brain ageing: Evidence from The Irish Longitudinal Study on Ageing (TILDA)
Slower speed of blood pressure recovery after standing is associated with accelerated brain ageing: Evidence from The Irish Longitudinal Study on Ageing (TILDA) Open
These results demonstrate that slower systolic and diastolic BP recovery in the early phase after standing is associated with accelerated brain aging in older individuals. This suggests that the BP response to standing, measured using beat…
View article: Haemodynamic Parameters Underlying the Relationship between Sarcopenia and Blood Pressure Recovery on Standing
Haemodynamic Parameters Underlying the Relationship between Sarcopenia and Blood Pressure Recovery on Standing Open
Background: Sarcopenia, delayed blood pressure (BP) recovery following standing, and orthostatic hypotension (OH) pose significant clinical challenges associated with ageing. While prior studies have established a link between sarcopenia a…
View article: Relationship between hippocampal subfield volumes and cognitive decline in healthy subjects
Relationship between hippocampal subfield volumes and cognitive decline in healthy subjects Open
We examined the relationship between hippocampal subfield volumes and cognitive decline over a 4-year period in a healthy older adult population with the goal of identifying subjects at risk of progressive cognitive impairment which could …
View article: Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA)
Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA) Open
In this observational study, we compared continuous physiological signals during an active stand test in adults aged 50 years and over, characterized as frail by three different criteria, using data from The Irish Longitudinal Study on Age…
View article: Haemodynamic Parameters Underlying the Relationship Between Sarcopenia and Blood Pressure Recovery on Standing
Haemodynamic Parameters Underlying the Relationship Between Sarcopenia and Blood Pressure Recovery on Standing Open
Background: Along with sarcopenia, delayed blood pressure (BP) recovery after standing and orthostatic hypotension (OH) are among key clinical challenges associated with ageing. Previous studies have reported an association between sarcope…
View article: Evaluation of a 3-Item Health Index in Predicting Mortality Risk: A 12-Year Follow-Up Study
Evaluation of a 3-Item Health Index in Predicting Mortality Risk: A 12-Year Follow-Up Study Open
This study was carried out using a large cohort (N = 4265; 416 deceased) of older, community-dwelling adults from The Irish Longitudinal Study on Ageing (TILDA). The study compared the performance of a new 3-item health index (HI) with two…
View article: Association of the frailty index with functional brain connectivity in the Irish Longitudinal Study on Ageing (TILDA)
Association of the frailty index with functional brain connectivity in the Irish Longitudinal Study on Ageing (TILDA) Open
Background Frailty, expressed as accumulation of health deficits in older adults, could contribute to the risk of cognitive decline. We cross‐sectionally studied the brain connectivity signatures of frailty in The Irish Longitudinal Study …
View article: Examining the Impact of Socioeconomic Position Across the Life Course on Cognitive Function and Brain Structure in Healthy Aging
Examining the Impact of Socioeconomic Position Across the Life Course on Cognitive Function and Brain Structure in Healthy Aging Open
This study explores the relationship of life-course intergenerational social mobility with cognitive function and brain structure in older adults using Diagonal Reference Models. Data from the Irish Longitudinal Study on Ageing, a populati…
View article: Structural brain signatures of frailty, defined as accumulation of self-reported health deficits in older adults
Structural brain signatures of frailty, defined as accumulation of self-reported health deficits in older adults Open
Background Frailty in older adults has been associated with reduced brain health. However, structural brain signatures of frailty remain understudied. Our aims were: (1) Explore associations between a frailty index (FI) and brain structure…
View article: “Dancing with Atoms”: A tribute to Sheila Tinney
“Dancing with Atoms”: A tribute to Sheila Tinney Open
In this study, a short dynamic visualization titled “Dancing with Atoms” was produced in honor of the late Irish mathematical physicist Sheila Tinney (1918–2010), who was the first Irish-born and -raised woman to receive a doctorate in the…
View article: Brain connectivity in frailty: Insights from The Irish Longitudinal Study on Ageing (TILDA)
Brain connectivity in frailty: Insights from The Irish Longitudinal Study on Ageing (TILDA) Open
Frailty in older adults is associated with greater risk of cognitive decline. Brain connectivity insights could help understand the association, but studies are lacking. We applied connectome-based predictive modeling to a 32-item self-rep…
View article: “Dancing with Atoms”: A Tribute to Sheila Tinney
“Dancing with Atoms”: A Tribute to Sheila Tinney Open
The authors present a short dynamic visualization titled “Dancing with Atoms,” produced in honor of the late Irish mathematical physicist Sheila Tinney (1918–2010), the first Irish-born and -raised woman to receive a doctorate in the mathe…
View article: Blood Pressure Signal Entropy as a Novel Marker of Physical Frailty: Results from the FRAILMatics Clinical Cohort
Blood Pressure Signal Entropy as a Novel Marker of Physical Frailty: Results from the FRAILMatics Clinical Cohort Open
In this study we investigated the association between information entropy in short length blood pressure signals and physical frailty status, in a group of patients aged 50+ recruited from the Falls and Syncope Unit at the Mercer’s Institu…
View article: Connectome‐based predictive modelling of cognitive reserve using task‐based functional connectivity
Connectome‐based predictive modelling of cognitive reserve using task‐based functional connectivity Open
Cognitive reserve supports cognitive function in the presence of pathology or atrophy. Functional neuroimaging may enable direct and accurate measurement of cognitive reserve which could have considerable clinical potential. The present st…
View article: Differential Associations Between Two Markers of Probable Sarcopenia and Continuous Orthostatic Hemodynamics in The Irish Longitudinal Study on Ageing
Differential Associations Between Two Markers of Probable Sarcopenia and Continuous Orthostatic Hemodynamics in The Irish Longitudinal Study on Ageing Open
Background Sarcopenia and orthostatic hypotension are growing age-related health burdens associated with adverse outcomes, including falls. Despite a possible pathophysiological link, the association between the 2 disorders is not well elu…