David Sim
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View article: Asian Pacific Society of Cardiology Consensus Statements on the Management of Worsening Heart Failure
Asian Pacific Society of Cardiology Consensus Statements on the Management of Worsening Heart Failure Open
Heart failure (HF) patients in the Asia-Pacific region face multiple challenges with disease management, such as the suboptimal use of optimised medical therapy immediately after discharge and during the maintenance phase of treatment. Bec…
View article: iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025
iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025 Open
Inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices as well as practical and political issues restrict the global applicability of currently available guidelines. There is a need f…
View article: iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025
iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025 Open
Inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices as well as practical and political issues restrict the global applicability of currently available guidelines. There is a need f…
View article: Development and Usability of an Advance Care Planning Website (My Voice) to Empower Patients With Heart Failure and Their Caregivers: Mixed Methods Study
Development and Usability of an Advance Care Planning Website (My Voice) to Empower Patients With Heart Failure and Their Caregivers: Mixed Methods Study Open
Background Web-based advance care planning (ACP) interventions offer a promising solution to improve ACP engagement, but none are specifically designed to meet the needs of patients with heart failure and their caregivers. Objective We aim…
View article: Empowering patients with heart failure and their caregivers: Development and usability of the “My Voice” advance care planning website (Preprint)
Empowering patients with heart failure and their caregivers: Development and usability of the “My Voice” advance care planning website (Preprint) Open
BACKGROUND Web-based advance care (ACP) interventions offer a promising solution to improve ACP engagement. However, there is lack of web-based ACP decision aids tailored for patients with heart failure, incorporating mechanisms to revisi…
View article: Unearthing Gaps in the Heart Failure Ecosystem: An Asian Pacific Society of Cardiology Online Survey
Unearthing Gaps in the Heart Failure Ecosystem: An Asian Pacific Society of Cardiology Online Survey Open
Background: Information about the availability and accessibility of diagnostics and treatments for heart failure (HF) is sparse. The aim of this study was to describe the gaps in the diagnosis and treatment of HF in member countries of the…
View article: Asian Pacific Society of Cardiology Consensus Statements on the Diagnosis and Management of Chronic Heart Failure
Asian Pacific Society of Cardiology Consensus Statements on the Diagnosis and Management of Chronic Heart Failure Open
In the Asia-Pacific region, heart failure (HF) is associated with significant health and socioeconomic burden. Given the differences in the epidemiology of HF, as well as the availability of healthcare resources between Asian and Western c…
View article: Efficacy and safety of vericiguat in patients with heart failure with reduced ejection fraction treated with sacubitril/valsartan: insights from the VICTORIA trial
Efficacy and safety of vericiguat in patients with heart failure with reduced ejection fraction treated with sacubitril/valsartan: insights from the VICTORIA trial Open
Aim We assessed a subset of the 5040 patients in VICTORIA receiving sacubitril/valsartan, either at randomization ( n = 731) or post‐randomization drop‐in use ( n = 425), to evaluate the relationship between the efficacy and safety of comb…
View article: Contemporary review of heart transplant immunology and immunosuppressive therapy
Contemporary review of heart transplant immunology and immunosuppressive therapy Open
Background Survival after heart transplantation (HT) has improved considerably since the first HT was performed in 1967 in Cape Town, South Africa. Understanding immunology behind organ rejection has paved way for advances in the assessmen…
View article: Epicardial adipose tissue related to left atrial and ventricular function in heart failure with preserved versus reduced and mildly reduced ejection fraction
Epicardial adipose tissue related to left atrial and ventricular function in heart failure with preserved versus reduced and mildly reduced ejection fraction Open
Aim Different associations between epicardial adipose tissue (EAT) and cardiac function have been suggested in patients with heart failure with preserved (HFpEF) versus reduced and mildly reduced ejection fraction (HFrEF/HFmrEF). However, …
View article: Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype
Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype Open
Aims The importance of iron deficiency (ID) in heart failure with preserved ejection fraction (HFpEF) is unknown. In HF with reduced ejection fraction (HFrEF), ID is reported as an independent predictor of mortality in HF although not all …
View article: Asian Pacific Society of Cardiology Consensus Recommendations on the Use of MitraClip for Mitral Regurgitation
Asian Pacific Society of Cardiology Consensus Recommendations on the Use of MitraClip for Mitral Regurgitation Open
Transcatheter mitral valve repair with the MitraClip, a catheter-based percutaneous edge-to-edge repair technique to correct mitral regurgitation (MR), has been demonstrated in Western studies to be an effective and safe MR treatment strat…
View article: Regional and ethnic influences on the response to empagliflozin in patients with heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial
Regional and ethnic influences on the response to empagliflozin in patients with heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial Open
Aims The aim of this article is to explore the influence of region and race/ethnicity on the effects of empagliflozin in the Empagliflozin Outcome Trial in Patients with Chronic Heart Failure and a Reduced Ejection Fraction (EMPEROR-Reduce…
View article: Urban Questions in the Times of Coronavirus. Responding to the Crisis of Public Space
Urban Questions in the Times of Coronavirus. Responding to the Crisis of Public Space Open
This paper is edited on the basis of intensive round-table discussions within a relatively small group of colleagues interested and involved in thinking, making and working towards quality of public space, to discuss, problematise and eval…
View article: Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial
Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial Open
Vifor Pharma.
View article: Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy
Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy Open
Background: Dilated cardiomyopathy (DCM) is genetically heterogeneous, with >100 purported disease genes tested in clinical laboratories. However, many genes were originally identified based on candidate-gene studies that did not adequatel…
View article: OP69 Effectiveness of advance care planning in improving end of life care for patients with advanced heart failure
OP69 Effectiveness of advance care planning in improving end of life care for patients with advanced heart failure Open
Background Our primary aim was to assess, among advanced heart failure patients, effectiveness of Advance care planning (ACP) in ensuring end of life (EOL) care consistent with patient wishes. Secondary aims were to assess its impact on pa…
View article: Baseline Characteristics of Patients With Heart Failure and Preserved Ejection Fraction in the PARAGON-HF Trial
Baseline Characteristics of Patients With Heart Failure and Preserved Ejection Fraction in the PARAGON-HF Trial Open
Background: To describe the baseline characteristics of patients with heart failure and preserved left ventricular ejection fraction enrolled in the PARAGON-HF trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With…
View article: P6193Beta-blockers improve mortality in acute heart failure patients regardless of rhythm and ejection fraction
P6193Beta-blockers improve mortality in acute heart failure patients regardless of rhythm and ejection fraction Open
1316 Acute heart failure (AHF) CHF patients (22.9% vs 13.9%, P<0.001).In multivariate analysis adjustment for 13 risk variables including age, sex, and brain natriuretic peptide, the hazard ratio for the mortality was increased in patients…
View article: Patient barriers to implantable cardioverter defi brillator implantation for the primary prevention of sudden cardiac death in patients with heart failure and reduced ejection fraction
Patient barriers to implantable cardioverter defi brillator implantation for the primary prevention of sudden cardiac death in patients with heart failure and reduced ejection fraction Open
This study identified the demographic and social factors of patients who refused ICD therapy. Knowledge of the role of ICDs in preventing SCD was found to be the strongest marker for reconsidering ICD implantation. Measures to address this…