Sima Shokri
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View article: Comparison of basophil activation testing and component-resolved diagnosis in patients with cross-reactive intradermal results after anaphylactic reactions to hymenoptera venom
Comparison of basophil activation testing and component-resolved diagnosis in patients with cross-reactive intradermal results after anaphylactic reactions to hymenoptera venom Open
View article: Primary Immunodeficiency Registry System: The Minimum Data Set Designing Phase—A Systematic Review and Quantitative Delphi Study
Primary Immunodeficiency Registry System: The Minimum Data Set Designing Phase—A Systematic Review and Quantitative Delphi Study Open
Background and Aims Registries are powerful tools for data management. Designing a minimum data set as the first step in registry development helps collect relevant and efficient data. The aim of this study was to develop a minimum data se…
View article: Safety of 1 mcg/mL as the starting dose in cluster protocol for hymenoptera immunotherapy
Safety of 1 mcg/mL as the starting dose in cluster protocol for hymenoptera immunotherapy Open
Background: Hymenoptera venom allergy is a potentially severe allergic reaction in the general population. The only preventative approach in these cases is venom immunotherapy (VIT), which follows different protocols. The recommended initi…
View article: Revisiting double-negative T cells in autoimmune lymphoproliferative immunodeficiencies: a case series
Revisiting double-negative T cells in autoimmune lymphoproliferative immunodeficiencies: a case series Open
Background: Elevated level of double-negative T (DNT) cells is a historical hallmark of autoimmune lymphoproliferative syndrome (ALPS) diagnosis. However, the peripheral blood level of DNT cells might also be compromised in autoimmune lymp…
View article: The role of molecular diagnosis in anaphylactic patients with dual or triple-sensitization to Hymenoptera venoms
The role of molecular diagnosis in anaphylactic patients with dual or triple-sensitization to Hymenoptera venoms Open
View article: Immune endotyping and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups
Immune endotyping and gene expression profile of patients with chronic rhinosinusitis with nasal polyps in the aspirin-exacerbated respiratory disease (AERD) and the non-AERD subgroups Open
Background Chronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP displays a T helper (Th)2 biased ph…
View article: From variant of uncertain significance to likely pathogenic in two siblings with atypical RAG2 Deficiency: a case report and review of the literature
From variant of uncertain significance to likely pathogenic in two siblings with atypical RAG2 Deficiency: a case report and review of the literature Open
Background Severe combined immunodeficiencies (SCIDs) are hereditary disorders characterized by impaired T and B cell function, resulting in significant immune system dysfunction. Recombination-activating gene ( RAG ) mutations account for…
View article: Respule or metered-dose inhaler for eosinophilic esophagitis treatment? A dose-ranging, randomized clinical trial study on efficacy, safety, and relapse rate
Respule or metered-dose inhaler for eosinophilic esophagitis treatment? A dose-ranging, randomized clinical trial study on efficacy, safety, and relapse rate Open
BackgroundEosinophilic esophagitis (EoE) is a chronic allergen/immune-mediated disease known by eosinophil infiltration into the esophagus. Topical steroids are used for its treatment. We investigated the efficacy, side effects, and sympto…
View article: COVID-19 Reinfection in Healthcare Workers: An Original Comprehensive Longitudinal Study
COVID-19 Reinfection in Healthcare Workers: An Original Comprehensive Longitudinal Study Open
Background The ongoing evolution of SARS-CoV-2 has perpetuated the global prevalence of coronavirus disease 2019 (COVID-19) and the emergence of new cases. Healthcare workers (HCWs), given their heightened exposure to infected individuals,…
View article: From Variant of Uncertain Significance to Likely Pathogenic in Two Siblings with Atypical RAG2 Deficiency: a case report and review of the literature
From Variant of Uncertain Significance to Likely Pathogenic in Two Siblings with Atypical RAG2 Deficiency: a case report and review of the literature Open
Background Severe combined immunodeficiencies (SCIDs) are hereditary disorders characterized by impaired T and B cell function, resulting in significant immune system dysfunction. Recombination-activating gene (RAG) mutations account for a…
View article: Immune Endotyping and Gene Expression Profile of Patients with Chronic Rhinosinusitis with Nasal Polyps in Aspirin-Exacerbated Respiratory Disease (AERD) and non-AERD Subgroups
Immune Endotyping and Gene Expression Profile of Patients with Chronic Rhinosinusitis with Nasal Polyps in Aspirin-Exacerbated Respiratory Disease (AERD) and non-AERD Subgroups Open
Background: Chronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP displays a T helper (Th)2 biased …
View article: The incidence rate and severity of COVID-19 infection in hospitalized vaccinated patients and outpatients who received remdesivir from March to September 2021 and outcome comparison between single and double vaccinated patients
The incidence rate and severity of COVID-19 infection in hospitalized vaccinated patients and outpatients who received remdesivir from March to September 2021 and outcome comparison between single and double vaccinated patients Open
Background: This study assessed the impact of COVID-19 vaccination on infection rates and severity, the protective period after vaccination, risk factors for hospitalization, and adverse reactions. It involved PCR-confirmed COVID-19 patien…
View article: From Variant of Uncertain Significance to Likely Pathogenic: Report of Two Siblings with Atypical RAG2 Deficiency
From Variant of Uncertain Significance to Likely Pathogenic: Report of Two Siblings with Atypical RAG2 Deficiency Open
Background: Severe combined immunodeficiencies (SCIDs) are hereditary disorders characterized by impaired T and B cell function, resulting in significant immune system dysfunction. Recombination-activating gene (RAG) mutations account for …
View article: Comparison of the Onset and End of Specific and Major Side Effects in Iranian Teenage Participants Vaccinated With COVID-19 Vaccine: Sinopharm and Soberana
Comparison of the Onset and End of Specific and Major Side Effects in Iranian Teenage Participants Vaccinated With COVID-19 Vaccine: Sinopharm and Soberana Open
The cardiovascular and hematological, joint-related (non-neurologic musculoskeletal) and dermatological side effects after the Soberana vaccine appear earlier and end later compared with the Sinopharm vaccine. Improvement of renal side eff…
View article: Investigation of the Relationship between Aspirin-Sensitivity and Poor Response to Medical Management in NSAIDs-exacerbated Respiratory Disease Patients with Sinonasal Polyposis
Investigation of the Relationship between Aspirin-Sensitivity and Poor Response to Medical Management in NSAIDs-exacerbated Respiratory Disease Patients with Sinonasal Polyposis Open
The severity of symptoms before treatment and clinical improvement after treatment are not good predictors of N-ERD.
View article: Diversity of malignancies in patients with different types of inborn errors of immunity
Diversity of malignancies in patients with different types of inborn errors of immunity Open
View article: The Uncomplicated Course of COVID-19 in Primary Immunodeficiency Patients: A Report of 14 Common Variable Immunodeficiency Patients
The Uncomplicated Course of COVID-19 in Primary Immunodeficiency Patients: A Report of 14 Common Variable Immunodeficiency Patients Open
Coronavirus disease 2019 (COVID-19) affects millions of people worldwide. Clinical manifestations range from asymptomatic to severe viral pneumonia. CVID patients with COVID-19 infection are not adequately studied. In some studies, CVID pa…
View article: Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19
Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19 Open
View article: The Effectiveness of Oral Immunotherapy in Patients with Sesame Anaphylaxis using Omalizumab
The Effectiveness of Oral Immunotherapy in Patients with Sesame Anaphylaxis using Omalizumab Open
This OIT protocol may be a promising desensitization strategy for patients with sesame anaphylaxis. Also, omalizumab appears to have reduced the severity of reactions.
View article: Neonatal Onset of Hemophagocytic Lymphohistiocytosis Due to Prenatal Varicella-Zoster Infection in a Neonate with Griscelli Syndrome Type 2
Neonatal Onset of Hemophagocytic Lymphohistiocytosis Due to Prenatal Varicella-Zoster Infection in a Neonate with Griscelli Syndrome Type 2 Open
Griscelli syndrome (GS) type 2 is an inborn error of the immune system classified as immune dysregulation. This autosomal recessive disease has three types with different genetic causes. In all variants, hypopigmentation is common, but neu…
View article: Pediatric and adolescent COVID‐19 vaccination side effects: A retrospective cohort study of the Iranian teenage group in 2021
Pediatric and adolescent COVID‐19 vaccination side effects: A retrospective cohort study of the Iranian teenage group in 2021 Open
To determine the safety and efficacy profile of teenager COVID‐19 vaccination. In this retrospective cohort study, contact numbers of parents of teenagers under 18 years of age referred to a teenager vaccination centers in Tehran‐Iran to r…
View article: Progressive multifocal leukoencephalopathy in a patient with novel mutation in the RAC2 gene: a case report
Progressive multifocal leukoencephalopathy in a patient with novel mutation in the RAC2 gene: a case report Open
Background Progressive multifocal leukoencephalopathy is a rare demyelinating disease that is often secondary to lytic destruction of oligodendrocytes and, to a lesser extent, to astrocytes’ response to human neurotrophic John Cunningham p…
View article: Immunologic response, Efficacy, and Safety of Vaccines against COVID-19 Infection in Healthy and immunosuppressed Children and Adolescents Aged 2 – 21 years old: A Systematic Review and Meta-analysis
Immunologic response, Efficacy, and Safety of Vaccines against COVID-19 Infection in Healthy and immunosuppressed Children and Adolescents Aged 2 – 21 years old: A Systematic Review and Meta-analysis Open
View article: Sustained unresponsiveness development in wheat oral immunotherapy: predictive factors and flexible regimen in the maintenance phase
Sustained unresponsiveness development in wheat oral immunotherapy: predictive factors and flexible regimen in the maintenance phase Open
Background. Immunotherapy may induce sustained unresponsiveness (SU )in which the patient can tolerate the allergen without any severe symptoms after discontinuing immunotherapy. The present study evaluated serum and cutaneous marke…
View article: Diversity of Malignancies in Patients with Different Types of Inborn Errors of Immunity
Diversity of Malignancies in Patients with Different Types of Inborn Errors of Immunity Open
Genetic defects in development, maturation, and/or function of immune cells can lead to Inborn errors of immunity (IEI) which may predispose patients to malignancies. Overall risk for cancer in children with IEI ranges from 4-25% and the t…
View article: Genetic and immunological evaluation of children with inborn errors of immunity and hypoxemic COVID-19 pneumonia
Genetic and immunological evaluation of children with inborn errors of immunity and hypoxemic COVID-19 pneumonia Open
Background: SARS-CoV-2 has infected more than 450 million people around the world. In about 10% of cases, the infection leads to hypoxemic pneumonia, which is much rarer in children, while multisystem inflammation…
View article: Genetic and immunological evaluation of children with inborn errors of immunity and hypoxemic COVID-19 pneumonia
Genetic and immunological evaluation of children with inborn errors of immunity and hypoxemic COVID-19 pneumonia Open
Background: SARS-CoV-2 has infected more than 450 million people around the world. In about 10% of cases, the infection leads to hypoxemic pneumonia, which is much rarer in children, while multisystem inflammation…
View article: Whole-transcriptome sequencing–based concomitant detection of viral and human genetic determinants of cutaneous lesions
Whole-transcriptome sequencing–based concomitant detection of viral and human genetic determinants of cutaneous lesions Open
Severe viral infections of the skin can occur in patients with inborn errors of immunity (IEI). We report an all-in-one whole-transcriptome sequencing-based method by RNA-Seq on a single skin biopsy for concomitantly identifying the cutane…
View article: Recalcitrant Cutaneous Warts in a Family with Inherited ICOS Deficiency
Recalcitrant Cutaneous Warts in a Family with Inherited ICOS Deficiency Open
View article: Immunologic response, Efficacy, and Safety of Vaccines Against COVID-19 Infection in Children and Adolescents Aged 2 – 21 years old: A Systematic Review
Immunologic response, Efficacy, and Safety of Vaccines Against COVID-19 Infection in Children and Adolescents Aged 2 – 21 years old: A Systematic Review Open
Backgrounds Children and adolescents form a large proportion of societies and play an important role in the transmission of COVID-19. On the other hand, their education, mental and physical wellness, and safety are compromised which makes …