Shan Gao
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Deep plowing improves soil physical structure and alters nitrogen-cycling microbial communities in a subtropical red soil region Open
Introduction Tillage depth plays a critical role in regulating soil structure, nutrient dynamics, and microbial processes that determine crop productivity and quality. Methods A 3-year field experiment was conducted in a subtropical red so…
View article: Chitosan oligosaccharide and Enteromorpha prolifera polysaccharides as additives affect the bacterial community and optimize the compost performance
Chitosan oligosaccharide and Enteromorpha prolifera polysaccharides as additives affect the bacterial community and optimize the compost performance Open
The yield of agricultural wastes is increasing year by year, and composting is a common and effective strategy. However, the influence of marine-derived carbohydrates such as chitosan oligosaccharide (COS) and Enteromorpha prolifera polysa…
Betaine protects cerebral microvascular endothelium and ameliorates hypertension-induced cognitive dysfunction via upregulation of the endothelial nitric oxide synthase/nitric monoxide signaling pathway Open
Objectives: Hypertension-induced endothelial damage in cerebral microvessels is a key factor contributing to vascular cognitive impairment (VCI). Endothelial function stabilization considerably depends on the endothelial nitric oxide synth…
Effect of miR-200c on inducing autophagy and apoptosis of HT22 cells from mouse hippocampal neurons via regulating PRDM1 protein: a bioinformatics analysis Open
To reveal the changes in microRNA (miRNA) expression profile in the hippocampus of mice with deep hypothermic circulatory arrest (DHCA) through bioinformatics analysis. The Support Vector Machine (SVM) algorithm in the Weka software was us…
Risk factors for postoperative ileus following posterior spinal instrumentation in thoracic and lumbar spine fractures: a case control study Open
Background The postoperative ileus (PI) was an unusual adverse effect, and the incidence and risk factors were still unclear. The purpose of present study was to clarify the prevalence of PI and elucidate the risk factors for PI following …
Recent Advances in the Mechanisms of Cell Death and Dysfunction in Doxorubicin Cardiotoxicity Open
Despite recent advances in cancer therapy, anthracycline-based combination therapy remains the standardized first-line strategy and has been found to have effective antitumor actions. Anthracyclines are extremely cardiotoxic, which limits …
View article: TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas
TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas Open
Background Myeloid cells comprise up to 50% of the total tumor mass in glioblastoma (GBM) and have been implicated in promoting tumor progression and immunosuppression. Modulating the response of myeloid cells to the tumor has emerged as a…
Fibroblast growth factor 23 regulates hypoxia‑induced osteoblast apoptosis through the autophagy‑signaling pathway Open
Hypoxia can lead to programmed osteoblast death. Prevention of osteoblast apoptosis caused by hypoxia is of great significance in the study of the occurrence and development of bone necrosis. The present study aimed to investigate the effe…
TREM2 mediates MHCII-associated CD4<sup>+</sup>T cell response against gliomas Open
Triggering receptor expressed on myeloid cells 2 (TREM2) was recently highlighted as a novel immune suppressive marker in peripheral tumors. The aim of this study was to characterize TREM2 expression in gliomas and investigate its contribu…
Development of Single-Cell Transcriptomics and Its Application in COVID-19 Open
Over the last three years, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related health crisis has claimed over six million lives and caused USD 12 trillion losses to the global economy. SARS-CoV-2 continuously mutates a…
Loss of exosomal micro-RNA-200b-3p from hypoxia cancer-associated fibroblasts reduces sensitivity to 5-flourouracil in colorectal cancer through targeting high-mobility group box 3 Open
Hypoxia-mediated tumor progression is a major problem in colorectal cancer (CRC). MicroRNA (miR)-200b-3p can attenuate tumorigenesis in CRC, while exosomal miRNAs derived from cancer-associated fibroblasts (CAFs) can promote cancer progres…
SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry Open
Significance We here established the interaction between PDZ binding motif (PBM) at the C terminal of ACE2 and PDZ domain of sorting nexin 27 (SNX27) and solved the crystal structure of ACE2-PBM/SNX27-PDZ complex. Together with retromer co…
Simultaneous Detection of Seven Human Coronaviruses by Multiplex PCR and MALDI-TOF MS Open
Human coronaviruses (HCoVs) are associated with a range of respiratory symptoms. The discovery of severe acute respiratory syndrome (SARS)-CoV, Middle East respiratory syndrome, and SARS-CoV-2 pose a significant threat to human health. In …
Palmitoylation of SARS‐CoV‐2 S protein is critical for S‐mediated syncytia formation and virus entry Open
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the cause of the ongoing coronavirus disease 2019 (COVID‐19) pandemic. The S protein is the key viral protein for associating with ACE2, the receptor for SARS‐CoV‐2. There are…
View article: Optimized collusion prevention for online exams during social distancing
Optimized collusion prevention for online exams during social distancing Open
Online education is important in the COVID-19 pandemic, but online exam at individual homes invites students to cheat in various ways, especially collusion. While physical proctoring is impossible during social distancing, online proctorin…
ACE2 isoform diversity predicts the host susceptibility of SARS‐CoV‐2 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19) pandemic. Angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2. In our current study, we found …
Scheme for Cheating Prevention in Online Exams during Social Distancing Open
In the current pandemic of COVID-19, students and faculty are subject to social distancing and online learning. How to test students in this unprecedented environment is a new educational challenge with immediate and global impacts. The ma…
A potential inhibitory role for integrin in the receptor targeting of SARS-CoV-2 Open
Corona Virus Disease 2019 (COVID-19) has caused a global pandemic in over 100 countries. Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) was identified as the pathogen of COVID-19. Both SARS-CoV-2 and SARS-CoV belong to the s…
Supplementary Material for: Epidemiology and Outcomes of Acute Kidney Injury in COVID-19 Patients with Acute Respiratory Distress Syndrome: A Multicenter Retrospective Study Open
Background: Acute kidney injury (AKI) is associated with increased mortality in patients with acute respiratory distress syndrome (ARDS). However, the epidemiological features and outcomes of AKI among COVID-19 patients with ARDS are unkno…
Recent Progress in Vaccine Development Against Chikungunya Virus Open
Chikungunya fever (CHIKF) is an acute infectious disease that is mediated by the mosquito-transmitted chikungunya virus (CHIKV). People infected with CHIKV may experience high fever, severe joint pain, skin rash, and headache. In recent ye…