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View article: FACED 2.0 enables large-scale voltage and calcium imaging in vivo
FACED 2.0 enables large-scale voltage and calcium imaging in vivo Open
Monitoring neuronal activity at large scale and high spatiotemporal resolution is crucial for understanding information processing within the brain. Here we optimized a kilohertz-frame-rate two-photon fluorescence microscope with an all-op…
View article: Scalable Human Cellular Models of Parkinson’s Disease Reveal A Druggable Link Between the Angiotensin Receptor 1 and α-Synuclein Pathology
Scalable Human Cellular Models of Parkinson’s Disease Reveal A Druggable Link Between the Angiotensin Receptor 1 and α-Synuclein Pathology Open
Background Parkinson’s disease (PD) involves progressive loss of midbrain dopaminergic (mDA) neurons in the substantia nigra. No disease-modifying treatments exist, only symptomatic relief. Our lab reported an unbiased screen in larval zeb…
View article: Emerging Roles of GluN3B NMDA Receptor Subunit in the Central Nervous System
Emerging Roles of GluN3B NMDA Receptor Subunit in the Central Nervous System Open
GluN3B is the most recently identified subunit of N-methyl-d-aspartate receptors (NMDARs), and gradually it has been found that it may be involved in regulating the development of central nervous system (CNS)-related diseases. Compared wit…
View article: Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia
Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia Open
Paradoxical kinesia—the temporary alleviation of motor deficits by powerful, urgent stimuli in Parkinson’s disease (PD)—remains poorly understood at the neural circuit level. Through chemo-genetic ablation of tyrosine hydroxylase-expressin…
View article: A High-Throughput Behavioral Assay for Screening Novel Anxiolytics in Larval Zebrafish
A High-Throughput Behavioral Assay for Screening Novel Anxiolytics in Larval Zebrafish Open
Background: Anxiety disorders affect millions of people worldwide, but current treatments often have limited effectiveness and produce unpredictable responses in patients. This underscores the need for novel anxiolytics. While behavior-bas…
View article: Antitumor Activity of Tetrahydro-β-carboline Derivatives via Inhibition of Kinesin Spindle Protein: Validation by Molecular Docking, Molecular Dynamics, and In Vitro Assays
Antitumor Activity of Tetrahydro-β-carboline Derivatives via Inhibition of Kinesin Spindle Protein: Validation by Molecular Docking, Molecular Dynamics, and In Vitro Assays Open
The tetrahydro-β-carboline heterocycle is a privileged scaffold found in numerous natural products and bioactive drugs, demonstrating significant potential for cancer therapy. In this study, we designed and synthesized 33 novel tetrahydro-…
View article: Classification of neurodegenerative diseases using brain effective connectivity and machine learning techniques: a systematic review
Classification of neurodegenerative diseases using brain effective connectivity and machine learning techniques: a systematic review Open
Background Effective connectivity (EC) refers to the directional influences or causal relationships between brain regions. In the field of artificial intelligence, machine learning has demonstrated remarkable proficiency in image recogniti…
View article: Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors
Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors Open
During asymmetric cell division (ACD) of radial glia progenitors (RGPs), the cortical polarity regulator Par-3 is detected in the cytoplasm colocalizing with dynein and Notch ligand DeltaD (Dld). What drives Par-3 to the cytoplasm and its …
View article: PCM1 conveys centrosome asymmetry to polarized endosome dynamics in regulating daughter cell fate
PCM1 conveys centrosome asymmetry to polarized endosome dynamics in regulating daughter cell fate Open
Vertebrate radial glia progenitors (RGPs), the principal neural stem cells, balance self-renewal and differentiation through asymmetric cell division (ACD), during which unequal inheritance of centrosomes is observed. Mechanistically, how …
View article: Deregulation of mitochondrial reverse electron transport alters the metabolism of reactive oxygen species and NAD<sup>+</sup>/NADH and presents a therapeutic target in Alzheimer’s disease
Deregulation of mitochondrial reverse electron transport alters the metabolism of reactive oxygen species and NAD<sup>+</sup>/NADH and presents a therapeutic target in Alzheimer’s disease Open
Aim: Oxidative stress and NAD+/NADH imbalance caused by alterations in reactive oxygen species (ROS) and NAD(H) metabolism are pathological features associated with normal aging and age-related diseases including Alzheimer’s disease (AD). …
View article: Collective dynamics of actin and microtubule and its crosstalk mediated by FHDC1
Collective dynamics of actin and microtubule and its crosstalk mediated by FHDC1 Open
The coordination between actin and microtubule network is crucial, yet this remains a challenging problem to dissect and our understanding of the underlying mechanisms remains limited. In this study, we used travelling waves in the cell co…
View article: Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior
Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior Open
Complex biological processes are regulated by both genetic and epigenetic programs. One class of epigenetic modifications is methylation. Evolutionarily conserved methyl-CpG-binding domain (MBD)-containing proteins are known as readers of …
View article: Protocol for image-based small-molecule screen to identify neuroprotective compounds for dopaminergic neurons in zebrafish
Protocol for image-based small-molecule screen to identify neuroprotective compounds for dopaminergic neurons in zebrafish Open
Whole-organism-based screen holds promise for discovering biologically active compounds. However, high-content imaging is challenging due to the difficulty of positioning live animals and individual variability of neuron counts. Here, we p…
View article: Causal Genetic Loci for a Motivated Behavior Spectrum Harbor Psychiatric Risk Genes
Causal Genetic Loci for a Motivated Behavior Spectrum Harbor Psychiatric Risk Genes Open
Summary Behavioral diversity is critical for population fitness. Individual differences in risk-taking are observed across species, but underlying genetic mechanisms and conservation are largely unknown. We examined dark avoidance in larva…
View article: Collective dynamics of formin and microtubule and its crosstalk mediated by FHDC1
Collective dynamics of formin and microtubule and its crosstalk mediated by FHDC1 Open
The coordination between actin and microtubule network is crucial, yet our understanding of the underlying mechanisms remains limited. In this study, we used travelling waves in the cell cortex to characterize the collective dynamics of cy…
View article: Supplementary Figures S1-S13; Supplementary Tables S1-S3, Supplementary Materials and Methods and Supplementary References from Inhibition of HSP90 by AUY922 Preferentially Kills Mutant <i>KRAS</i> Colon Cancer Cells by Activating Bim through ER Stress
Supplementary Figures S1-S13; Supplementary Tables S1-S3, Supplementary Materials and Methods and Supplementary References from Inhibition of HSP90 by AUY922 Preferentially Kills Mutant <i>KRAS</i> Colon Cancer Cells by Activating Bim through ER Stress Open
Supplementary Figure S1. AUY922 does not significantly affect viability of normal colon epithelial cells; Supplementary Figure S2. Sensitivity of colon cancer cells to AUY922 is not associated with the expression levels of HSP90; Supplemen…
View article: Data from Inhibition of HSP90 by AUY922 Preferentially Kills Mutant <i>KRAS</i> Colon Cancer Cells by Activating Bim through ER Stress
Data from Inhibition of HSP90 by AUY922 Preferentially Kills Mutant <i>KRAS</i> Colon Cancer Cells by Activating Bim through ER Stress Open
Oncogenic mutations of KRAS pose a great challenge in the treatment of colorectal cancer. Here we report that mutant KRAS colon cancer cells are nevertheless more susceptible to apoptosis induced by the HSP90 inhibitor AUY922 than those ca…
View article: Data from Inhibition of HSP90 by AUY922 Preferentially Kills Mutant <i>KRAS</i> Colon Cancer Cells by Activating Bim through ER Stress
Data from Inhibition of HSP90 by AUY922 Preferentially Kills Mutant <i>KRAS</i> Colon Cancer Cells by Activating Bim through ER Stress Open
Oncogenic mutations of KRAS pose a great challenge in the treatment of colorectal cancer. Here we report that mutant KRAS colon cancer cells are nevertheless more susceptible to apoptosis induced by the HSP90 inhibitor AUY922 than those ca…
View article: Supplementary Figures S1-S13; Supplementary Tables S1-S3, Supplementary Materials and Methods and Supplementary References from Inhibition of HSP90 by AUY922 Preferentially Kills Mutant <i>KRAS</i> Colon Cancer Cells by Activating Bim through ER Stress
Supplementary Figures S1-S13; Supplementary Tables S1-S3, Supplementary Materials and Methods and Supplementary References from Inhibition of HSP90 by AUY922 Preferentially Kills Mutant <i>KRAS</i> Colon Cancer Cells by Activating Bim through ER Stress Open
Supplementary Figure S1. AUY922 does not significantly affect viability of normal colon epithelial cells; Supplementary Figure S2. Sensitivity of colon cancer cells to AUY922 is not associated with the expression levels of HSP90; Supplemen…
View article: Supplementary Information from A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence
Supplementary Information from A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence Open
Supplementary Table 1. A summary of miRNAs that are expressed at higher levels in G0 cells than G1 cells. Supplementary Table 2. List of antibodies. Supplementary Table 3. List of Reagents. Supplementary Table 4. siRNA and shRNA sequences.…
View article: Supplementary Figures from A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence
Supplementary Figures from A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence Open
Supplementary Figure 1: MiR-27b-3p and miR-455-3p promote cellular quiescence in B16 mouse melanoma cells. Supplementary Figure 2: miR-27b-3p and miR-455-3p are conserved in various mammal species. Supplementary Figure 3: MiR-27b-3p and mi…
View article: Supplementary Figures from A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence
Supplementary Figures from A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence Open
Supplementary Figure 1: MiR-27b-3p and miR-455-3p promote cellular quiescence in B16 mouse melanoma cells. Supplementary Figure 2: miR-27b-3p and miR-455-3p are conserved in various mammal species. Supplementary Figure 3: MiR-27b-3p and mi…
View article: Data from A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence
Data from A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence Open
Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complem…
View article: Data from A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence
Data from A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence Open
Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complem…