Simeon Andrews
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View article: A cord of four strands: Perspective of pre‐medical and medical students on combined teaching modalities in undergraduate biochemistry
A cord of four strands: Perspective of pre‐medical and medical students on combined teaching modalities in undergraduate biochemistry Open
Despite being a traditional coursework for pre‐medical and medical students around the globe, biochemistry education suffers from a lack of positive appreciation due to the nature of the subject combined with deficiency of teaching modalit…
View article: Regulation of Circular RNA CircNFATC3 in Cancer Cells Alters Proliferation, Migration, and Oxidative Phosphorylation
Regulation of Circular RNA CircNFATC3 in Cancer Cells Alters Proliferation, Migration, and Oxidative Phosphorylation Open
Circular RNAs were once considered artifacts of transcriptome sequencing but have recently been identified as functionally relevant in different types of cancer. Although there is still no clear main function of circRNAs, several studies h…
View article: Regulation of circular RNA circNFATc3 in cancer cells alters proliferation, migration and oxidative phosphorylation
Regulation of circular RNA circNFATc3 in cancer cells alters proliferation, migration and oxidative phosphorylation Open
Circular RNAs were once considered artifacts of transcriptome sequencing but have recently been identified as functionally relevant in multiple cancers. Although there is still no clear main function of circRNAs, several studies have revea…
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View article: Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes
Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes Open
Our study demonstrates the functional relevance of circANKRD12 in various cancer cell types and, based on its expression pattern, has the potential to become a new clinical biomarker.
View article: High-resolution protein–protein interaction mapping using all-versus-all sequencing (AVA-Seq)
High-resolution protein–protein interaction mapping using all-versus-all sequencing (AVA-Seq) Open
Two-hybrid systems can be used for investigating protein-protein interactions and may provide important information about gene products with unknown function. Despite their success in mapping protein interactions, two-hybrid systems have r…
View article: Additional file 5: of Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes
Additional file 5: of Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes Open
Supplementary file S1. List of genes differentially expressed in circANKRD12 silenced cells compared to control in different cell lines. (XLSX 160 kb)
View article: Additional file 6: of Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes
Additional file 6: of Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes Open
Table S6. List of microRNAs that can target circANKRD12 and CyclinD1. (XLSX 9 kb)
View article: Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes
Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes Open
Circular RNAs (circRNA) that form through non-canonical backsplicing events of pre-mRNA transcripts are evolutionarily conserved and abundantly expressed across species. However, the functional relevance of circRNAs remains a topic of deba…
View article: Open Reading Frame Filtering Methods for Identification of Genic Sequences
Open Reading Frame Filtering Methods for Identification of Genic Sequences Open
View article: Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma
Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma Open
Recently, a class of endogenous species of RNA called circular RNA (circRNA) has been shown to regulate gene expression in mammals and their role in cellular function is just beginning to be understood. To investigate the role of circRNAs …
View article: K-core decomposition of a protein domain co-occurrence network reveals lower cancer mutation rates for interior cores
K-core decomposition of a protein domain co-occurrence network reveals lower cancer mutation rates for interior cores Open
Mutations and domain co-occurrence networks provide a framework for understanding hierarchal designs in protein function from a network perspective. This study provides evidence that a majority of protein domains in the inner core of the D…