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View article: Caver Web 2.0: analysis of tunnels and ligand transport in dynamic ensembles of proteins
Caver Web 2.0: analysis of tunnels and ligand transport in dynamic ensembles of proteins Open
Enzymes with buried active sites utilize molecular tunnels to exchange substrates, products, and solvent molecules with the surface. These transport mechanisms are crucial for protein function and influence various properties. As proteins …
View article: Analysis of mutations in precision oncology using the automated, accurate, and user-friendly web tool PredictONCO
Analysis of mutations in precision oncology using the automated, accurate, and user-friendly web tool PredictONCO Open
Next-generation sequencing technology has created many new opportunities for clinical diagnostics, but it faces the challenge of functional annotation of identified mutations. Various algorithms have been developed to predict the impact of…
View article: A computational workflow for analysis of missense mutations in precision oncology
A computational workflow for analysis of missense mutations in precision oncology Open
Every year, more than 19 million cancer cases are diagnosed, and this number continues to increase annually. Since standard treatment options have varying success rates for different types of cancer, understanding the biology of an individ…
View article: Analysis of Mutations in Precision Oncology using The Automated, Accurate, and User-Friendly Web Tool PredictONCO
Analysis of Mutations in Precision Oncology using The Automated, Accurate, and User-Friendly Web Tool PredictONCO Open
Next-generation sequencing technology has created many new opportunities for clinical diagnostics, but it faces the challenge of functional annotation of identified mutations. Various algorithms have been developed to predict the impact of…
View article: A Computational Workflow for Analysis of Missense Mutations in Precision Oncology
A Computational Workflow for Analysis of Missense Mutations in Precision Oncology Open
Every year, more than 19 million cancer cases are diagnosed, and this number continues to increase annually. Since standard treatment options have varying success rates for different types of cancer, understanding the biology of an individ…
View article: AggreProt: a web server for predicting and engineering aggregation prone regions in proteins
AggreProt: a web server for predicting and engineering aggregation prone regions in proteins Open
Recombinant proteins play pivotal roles in numerous applications including industrial biocatalysts or therapeutics. Despite the recent progress in computational protein structure prediction, protein solubility and reduced aggregation prope…
View article: Training and test datasets for the PredictONCO tool
Training and test datasets for the PredictONCO tool Open
This dataset was used for training and validating the PredictONCO web tool, supporting decision-making in precision oncology by extending the bioinformatics predictions with advanced computing and machine learning. The dataset consists of …
View article: Training and test datasets for the PredictONCO tool
Training and test datasets for the PredictONCO tool Open
This dataset was used for training and validating the PredictONCO web tool, supporting decision-making in precision oncology by extending the bioinformatics predictions with advanced computing and machine learning. The dataset consists of …
View article: PredictONCO: a web tool supporting decision-making in precision oncology by extending the bioinformatics predictions with advanced computing and machine learning
PredictONCO: a web tool supporting decision-making in precision oncology by extending the bioinformatics predictions with advanced computing and machine learning Open
PredictONCO 1.0 is a unique web server that analyzes effects of mutations on proteins frequently altered in various cancer types. The server can assess the impact of mutations on the protein sequential and structural properties and apply a…
View article: FireProt 2.0: web-based platform for the fully automated design of thermostable proteins
FireProt 2.0: web-based platform for the fully automated design of thermostable proteins Open
Thermostable proteins find their use in numerous biomedical and biotechnological applications. However, the computational design of stable proteins often results in single-point mutations with a limited effect on protein stability. However…
View article: Training and test datasets for the PredictONCO tool
Training and test datasets for the PredictONCO tool Open
This dataset was used for training and validating the PredictONCO web tool, supporting decision-making in precision oncology by extending the bioinformatics predictions with advanced computing and machine learning. The dataset consists of …
View article: EnzymeMiner: automated mining of soluble enzymes with diverse structures, catalytic properties and stabilities
EnzymeMiner: automated mining of soluble enzymes with diverse structures, catalytic properties and stabilities Open
Millions of protein sequences are being discovered at an incredible pace, representing an inexhaustible source of biocatalysts. Despite genomic databases growing exponentially, classical biochemical characterization techniques are time-dem…