Simerdeep K. Dhillon
YOU?
Author Swipe
View article: Delayed necrostatin-1s infusion attenuates cystic white matter injury in preterm fetal sheep
Delayed necrostatin-1s infusion attenuates cystic white matter injury in preterm fetal sheep Open
Severe, cystic white matter injury (WMI) in preterm infants is associated with neurodevelopmental impairment. Strikingly, it often develops weeks after birth. In the present study we tested the hypothesis that necrotic programmed cell deat…
View article: Preventive, rescue and reparative neuroprotective strategies for the fetus and neonate
Preventive, rescue and reparative neuroprotective strategies for the fetus and neonate Open
Neonatal encephalopathy remains a major contributor to death and disability around the world. Acute hypoxia-ischaemia before, during or after birth creates a series of events that can lead to neonatal brain injury. Understanding the evolut…
View article: The peripheral chemoreflex and fetal defenses against intrapartum hypoxic-ischemic brain injury at term gestation
The peripheral chemoreflex and fetal defenses against intrapartum hypoxic-ischemic brain injury at term gestation Open
Fetal hypoxemia is ubiquitous during labor and, when severe, is associated with perinatal death and long-term neurodevelopmental disability. Adverse outcomes are highly associated with barriers to care, such that developing countries have …
View article: Can or should we try to predict preterm white matter injury?
Can or should we try to predict preterm white matter injury? Open
View article: Enhanced EEG seizure recognition after hypoxia-ischemia in fetal sheep using transformer-based wavelet-scalogram deep learning
Enhanced EEG seizure recognition after hypoxia-ischemia in fetal sheep using transformer-based wavelet-scalogram deep learning Open
This study introduces transformer-based deep learning models as superior alternatives to convolutional neural network (CNN) architectures for seizure detection after hypoxia–ischemia (HI) in electroencephalography (EEG) recordings in the d…
View article: How do we reach the goal of personalized medicine for neuroprotection in neonatal hypoxic-ischemic encephalopathy?
How do we reach the goal of personalized medicine for neuroprotection in neonatal hypoxic-ischemic encephalopathy? Open
Therapeutic hypothermia is now standard of care for neonates with hypoxic-ischemic encephalopathy (HIE) in high income countries (HIC). Conversely, compelling trial evidence suggests that hypothermia is ineffective, and may be deleterious,…
View article: Could we detect intraventricular hemorrhage before it happens?
Could we detect intraventricular hemorrhage before it happens? Open
Germinal matrix intraventricular hemorrhage (IVH) is a serious complication of extremely preterm birth. 1 Its effects can be devastating, with high risks of death and severe neurodevelopmental disability, mainly after higher grade of hemor…
View article: Dysmaturation of sleep state and electroencephalographic activity after hypoxia-ischaemia in preterm fetal sheep
Dysmaturation of sleep state and electroencephalographic activity after hypoxia-ischaemia in preterm fetal sheep Open
Antenatal hypoxia-ischaemia (HI) in preterm fetal sheep can trigger delayed evolution of severe, cystic white matter injury (WMI), in a similar timecourse to WMI in preterm infants. We therefore examined how severe hypoxia-ischaemia affect…
View article: Deep Learning for Generalized EEG Seizure Detection after Hypoxia–Ischemia—Preclinical Validation
Deep Learning for Generalized EEG Seizure Detection after Hypoxia–Ischemia—Preclinical Validation Open
Brain maturity and many clinical treatments such as therapeutic hypothermia (TH) can significantly influence the morphology of neonatal EEG seizures after hypoxia–ischemia (HI), and so there is a need for generalized automatic seizure iden…
View article: Postischemic Infusion of Apigenin Reduces Seizure Burden in Preterm Fetal Sheep
Postischemic Infusion of Apigenin Reduces Seizure Burden in Preterm Fetal Sheep Open
Seizures are common in preterm newborns and are associated with poor neurodevelopmental outcomes. Current anticonvulsants have poor efficacy, and many have been associated with upregulation of apoptosis in the developing brain. Apigenin, a…
View article: The neural and cardiovascular effects of exposure of gram-positive bacterial inflammation in preterm fetal sheep
The neural and cardiovascular effects of exposure of gram-positive bacterial inflammation in preterm fetal sheep Open
Perinatal infection or inflammation are associated with adverse neurodevelopmental effects and cardiovascular impairments in preterm infants. Most preclinical studies have examined the effects of gram-negative bacterial inflammation on the…
View article: Circadian patterns of heart rate variability in fetal sheep after hypoxia‐ischaemia: A biomarker of evolving brain injury
Circadian patterns of heart rate variability in fetal sheep after hypoxia‐ischaemia: A biomarker of evolving brain injury Open
Hypoxia‐ischaemia (HI) before birth is a key risk factor for stillbirth and severe neurodevelopmental disability in survivors, including cerebral palsy, although there are no reliable biomarkers to detect at risk fetuses that may have suff…
View article: Dissecting the contributions of the peripheral chemoreflex and myocardial hypoxia to fetal heart rate decelerations in near‐term fetal sheep
Dissecting the contributions of the peripheral chemoreflex and myocardial hypoxia to fetal heart rate decelerations in near‐term fetal sheep Open
Brief repeated fetal hypoxaemia during labour can trigger intrapartum decelerations of the fetal heart rate (FHR) via the peripheral chemoreflex or the direct effects of myocardial hypoxia, but the relative contribution of these two mechan…
View article: Magnesium sulphate reduces tertiary gliosis but does not improve EEG recovery or white or grey matter cell survival after asphyxia in preterm fetal sheep
Magnesium sulphate reduces tertiary gliosis but does not improve EEG recovery or white or grey matter cell survival after asphyxia in preterm fetal sheep Open
Maternal magnesium sulphate (MgSO 4 ) treatment is widely recommended before preterm birth for neuroprotection. However, this is controversial because there is limited evidence that MgSO 4 provides long‐term neuroprotection. Preterm fetal …
View article: Alpha-adrenergic receptor activation after fetal hypoxia-ischaemia suppresses transient epileptiform activity and limits loss of oligodendrocytes and hippocampal neurons
Alpha-adrenergic receptor activation after fetal hypoxia-ischaemia suppresses transient epileptiform activity and limits loss of oligodendrocytes and hippocampal neurons Open
Exposure to hypoxic-ischaemia (HI) is consistently followed by a delayed fall in cerebral perfusion. In preterm fetal sheep this is associated with impaired cerebral oxygenation, consistent with mismatch between perfusion and metabolism. I…
View article: Tumour necrosis factor blockade after asphyxia in foetal sheep ameliorates cystic white matter injury
Tumour necrosis factor blockade after asphyxia in foetal sheep ameliorates cystic white matter injury Open
Cystic white matter injury is highly associated with severe neurodevelopmental disability and cerebral palsy in preterm infants, yet its pathogenesis remains poorly understood and there is no established treatment. In the present study, we…
View article: Targeting Persistent Neuroinflammation after Hypoxic-Ischemic Encephalopathy—Is Exendin-4 the Answer?
Targeting Persistent Neuroinflammation after Hypoxic-Ischemic Encephalopathy—Is Exendin-4 the Answer? Open
Hypoxic-ischemic encephalopathy is brain injury resulting from the loss of oxygen and blood supply around the time of birth. It is associated with a high risk of death or disability. The only approved treatment is therapeutic hypothermia. …
View article: Fetal growth restriction and stillbirth: Biomarkers for identifying at risk fetuses
Fetal growth restriction and stillbirth: Biomarkers for identifying at risk fetuses Open
Fetal growth restriction (FGR) is a major cause of stillbirth, prematurity and impaired neurodevelopment. Its etiology is multifactorial, but many cases are related to impaired placental development and dysfunction, with reduced nutrient a…
View article: Lack of Neuroprotection with a Single Intravenous Infusion of Human Amnion Epithelial Cells after Severe Hypoxia–Ischemia in Near-Term Fetal Sheep
Lack of Neuroprotection with a Single Intravenous Infusion of Human Amnion Epithelial Cells after Severe Hypoxia–Ischemia in Near-Term Fetal Sheep Open
Background: Hypoxic–ischemic encephalopathy (HIE) around the time of birth results from loss of oxygen (hypoxia) and blood supply (ischemia). Exogenous infusion of multi-potential cells, including human amnion epithelial cells (hAECs), can…
View article: Cerebral Oxygenation and Metabolism After Hypoxia-Ischemia
Cerebral Oxygenation and Metabolism After Hypoxia-Ischemia Open
Perinatal hypoxia-ischemia (HI) is still a significant contributor to mortality and adverse neurodevelopmental outcomes in term and preterm infants. HI brain injury evolves over hours to days, and involves complex interactions between the …
View article: Prognostic Neurobiomarkers in Neonatal Encephalopathy
Prognostic Neurobiomarkers in Neonatal Encephalopathy Open
Therapeutic hypothermia (TH) is now a standard treatment for infants with moderate-to-severe neonatal encephalopathy (NE), and improves brain damage on neuroimaging and neurodevelopmental outcomes. Critically, for effective neuroprotection…
View article: Is Late Prevention of Cerebral Palsy in Extremely Preterm Infants Plausible?
Is Late Prevention of Cerebral Palsy in Extremely Preterm Infants Plausible? Open
Preterm birth continues to be associated with neurodevelopmental problems including cerebral palsy. Cystic white matter injury (WMI) is still the major neuropathology underlying cerebral palsy, affecting 1–3% of preterm infants. Although r…
View article: Preventing Brain Injury in the Preterm Infant—Current Controversies and Potential Therapies
Preventing Brain Injury in the Preterm Infant—Current Controversies and Potential Therapies Open
Preterm birth is associated with a high risk of morbidity and mortality including brain damage and cerebral palsy. The development of brain injury in the preterm infant may be influenced by many factors including perinatal asphyxia, infect…
View article: Recombinant erythropoietin does not augment hypothermic white matter protection after global cerebral ischaemia in near-term fetal sheep
Recombinant erythropoietin does not augment hypothermic white matter protection after global cerebral ischaemia in near-term fetal sheep Open
Therapeutic hypothermia for hypoxic-ischaemic encephalopathy provides partial white matter protection. Recombinant erythropoietin reduces demyelination after hypoxia-ischaemia, but it is unclear whether adjunct erythropoietin treatment can…
View article: Magnetic Resonance Imaging Correlates of White Matter Gliosis and Injury in Preterm Fetal Sheep Exposed to Progressive Systemic Inflammation
Magnetic Resonance Imaging Correlates of White Matter Gliosis and Injury in Preterm Fetal Sheep Exposed to Progressive Systemic Inflammation Open
Progressive fetal infection/inflammation is strongly associated with neural injury after preterm birth. We aimed to test the hypotheses that progressively developing fetal inflammation leads to neuroinflammation and impaired white matter d…
View article: Lipopolysaccharide-induced changes in the neurovascular unit in the preterm fetal sheep brain
Lipopolysaccharide-induced changes in the neurovascular unit in the preterm fetal sheep brain Open
Background Exposure to inflammation during pregnancy can predispose to brain injury in premature infants. In the present study, we investigated the effects of prolonged exposure to inflammation on the cerebrovasculature of preterm fetal sh…
View article: The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep
The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep Open
High-dose human recombinant erythropoietin (rEPO) is a promising potential neuroprotective treatment in preterm and full-term neonates with hypoxic-ischemic encephalopathy (HIE). There are limited data on the pharmacokinetics of high-dose …
View article: Tumor necrosis factor inhibition attenuates white matter gliosis after systemic inflammation in preterm fetal sheep
Tumor necrosis factor inhibition attenuates white matter gliosis after systemic inflammation in preterm fetal sheep Open
View article: Protective effects of delayed intraventricular TLR7 agonist administration on cerebral white and gray matter following asphyxia in the preterm fetal sheep
Protective effects of delayed intraventricular TLR7 agonist administration on cerebral white and gray matter following asphyxia in the preterm fetal sheep Open
Preterm brain injury is highly associated with inflammation, which is likely related in part to sterile responses to hypoxia-ischemia. We have recently shown that neuroprotection with inflammatory pre-conditioning in the immature brain is …
View article: Limited benefit of slow rewarming after cerebral hypothermia for global cerebral ischemia in near-term fetal sheep
Limited benefit of slow rewarming after cerebral hypothermia for global cerebral ischemia in near-term fetal sheep Open
The optimal rate of rewarming after therapeutic hypothermia for neonatal hypoxic–ischemic encephalopathy is unknown, although it is widely suggested that slow rewarming is beneficial. Some preclinical studies suggest better outcomes with s…