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Machine Learning in Anesthesia: Overcoming Variability in Drug Response and Patient Sensitivity Open
Background: Patients exhibit different anesthesia responses because their genetic makeup and metabolic pathways and their medical conditions and their demographic background differ. Standard anesthesia dosing protocols fail to recognize pa…
View article: Contrast-Enhanced Ultrasound to Assess Kidney Quality During Ex Situ Normothermic Machine Perfusion
Contrast-Enhanced Ultrasound to Assess Kidney Quality During Ex Situ Normothermic Machine Perfusion Open
Normothermic machine perfusion (NMP) provides opportunity for viability assessment of donated kidneys. Diminished microvascular perfusion, despite adequate total blood flow, is a key pathophysiology in ischaemia-mediated acute kidney injur…
View article: 54 Contrast-enhanced ultrasound to assess kidney quality during ex situ normothermic machine perfusion
54 Contrast-enhanced ultrasound to assess kidney quality during ex situ normothermic machine perfusion Open
Background Normothermic machine perfusion (NMP) provides opportunity for viability assessment of donated kidneys. Diminished microvascular perfusion, despite adequate total blood flow, is a key pathophysiology in ischaemia reperfusion inju…
Socio Fuzzy Based Performance Evaluation of Cloud Computing Service Model (IaaS) Open
Socio fuzzy based research is primarily focused on recovery of disaster in cloud computing and the spread of this technology with an enormous speed, which is sufficient to explain the need and desirability of this technology, on the other …
DERMATOLOGICAL MANIFESTATIONS OF INFECTIOUS DISEASES: A GLOBAL PUBLIC HEALTH CONCERN Open
Background: Infectious diseases pose a persistent global public health challenge, with dermatological symptoms often serving as pivotal indicators of underlying infections. Recognizing and understanding these manifestations are essential f…
I Dentification Immunohistological Changes in the Thymus Gland of Male and Female Rats With Indocrine Glands Disorder Open
Endocrine disorders is the result of a hormone imbalance, a condition characterized by a gland producing too much or too little of a hormone. This imbalance can be caused by:Issues with the endocrines feedback system−its main job is to kee…
FREQUENCY OF HEPATITIS B AND C SEROPOSITIVITY AMONGST PATIENTS UNDERGOING HEMODIALYSIS Open
Hepatitis is caused by many viruses, but Hepatitis B and C viruses are the most harmful, showing a unique and noteworthy correlation between kidney disorders and hemodialysis in individuals. Objective: This study aimed to determine the fre…
View article: O180: An In Vitro Cell Model to Assess the Effects of Complement Inhibition on Ischemia-Reperfusion Injury in Cholangiocytes
O180: An In Vitro Cell Model to Assess the Effects of Complement Inhibition on Ischemia-Reperfusion Injury in Cholangiocytes Open
Background Liver transplantation is the definitive procedure for end-stage liver failure but is limited by a shortage of viable donor organs. IRI is an unavoidable consequence of transplantation, triggering damage via several pathways, inc…
View article: Correction: del Molino del Barrio et al. Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12. Int. J. Mol. Sci. 2018, 19, 3592
Correction: del Molino del Barrio et al. Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12. Int. J. Mol. Sci. 2018, 19, 3592 Open
The authors and Editorial Office were made aware of an error in a figure within the original publication [...]
View article: Dissecting the Therapeutic Mechanisms of Sphingosine-1-Phosphate Receptor Agonism during Ischaemia and Reperfusion
Dissecting the Therapeutic Mechanisms of Sphingosine-1-Phosphate Receptor Agonism during Ischaemia and Reperfusion Open
Sphingosine 1-phosphate (S1P) and S1P receptors (S1PR) regulate many cellular processes, including lymphocyte migration and endothelial barrier function. As neutrophils are major mediators of inflammation, their transendothelial migration …
#5885 HYPOXIA INDUCES COMPLEMENT ACTIVATION ON HUMAN KIDNEY EPITHELIAL CELLS Open
Background and Aims Ischemia-reperfusion injury is an inevitable event associated with kidney transplantation (Tx) and has a major impact on short- and long-term graft survival. Proximal tubular epithelial cells are both a source of comple…
View article: Modeling the Effects of IL-1β-mediated Inflammation During Ex Vivo Lung Perfusion Using a Split Human Donor Model
Modeling the Effects of IL-1β-mediated Inflammation During Ex Vivo Lung Perfusion Using a Split Human Donor Model Open
Background. The association between interleukin-1β (IL-1β) concentrations during ex vivo lung perfusion (EVLP) with donor organ quality and post-lung transplant outcome has been demonstrated in several studies. The mechanism underlying IL-…
View article: O049 Interleukin-16 in flush effluent fluid as a biomarker for kidney viability prior to transplantation
O049 Interleukin-16 in flush effluent fluid as a biomarker for kidney viability prior to transplantation Open
Background Kidney transplantation is limited by the number of transplantable organs. Biomarkers that can predict organ viability will reduce the number of organs currently discarded (13% UK, 2021-22, NHSBT). The kidney microcirculation can…
Nitration of Chemokine CXCL8 acts as a natural mechanism to limit acute inflammation Open
Chemokine CXCL8 is a key facilitator of the human host immune response, mediating neutrophil migration and activation at the site of infection and injury. The oxidative burst is an important effector mechanism which leads to the generation…
MiR-126-3p Is Dynamically Regulated in Endothelial-to-Mesenchymal Transition during Fibrosis Open
In fibrotic diseases, myofibroblasts derive from a range of cell types including endothelial-to-mesenchymal transition (EndMT). Increasing evidence suggests that miRNAs are key regulators in biological processes but their profile is relati…
Contribution of Heparan Sulphate Binding in CCL21-Mediated Migration of Breast Cancer Cells Open
Chemokine receptor CCR7 is implicated in the metastasis of breast cancer to the lymph nodes. Chemokine function is dependent upon their binding to both cell-surface heparan sulphate (HS) and to their specific receptors; thus, the role of H…
View article: O3 Ex vivo normothermic machine perfusion facilitates gymnotic delivery of RNA interference therapeutics in donor kidneys
O3 Ex vivo normothermic machine perfusion facilitates gymnotic delivery of RNA interference therapeutics in donor kidneys Open
Introduction Normothermic machine perfusion (NMP) of donor kidneys prior to transplantation provides a platform for delivery of novel therapeutics to optimize organ quality. This includes RNA interference (RNAi) therapeutics e.g. antisense…
View article: O25: TARGETING THE RENAL TUBULAR EPITHELIUM WITH ANTI-MIRNA THERAPY: A POTENTIAL MECHANISM FOR MINIMISING ISCHAEMIA REPERFUSION INJURY
O25: TARGETING THE RENAL TUBULAR EPITHELIUM WITH ANTI-MIRNA THERAPY: A POTENTIAL MECHANISM FOR MINIMISING ISCHAEMIA REPERFUSION INJURY Open
Introduction Ischaemia reperfusion injury (IRI) is an unavoidable, significant consequence of renal transplantation. MicroRNAs are small, non-coding RNA molecules that regulate multiple downstream mRNA targets. MiRNA-21-5p and miRNA-24-3p …
View article: Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury
Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury Open
Objective Myocardial infarction leads to a rapid innate immune response that is ultimately required for repair of damaged heart tissue. We therefore examined circulating monocyte dynamics immediately after reperfusion of the culprit corona…
View article: Cell therapy during machine perfusion
Cell therapy during machine perfusion Open
There has been increasing use of organs from extended criteria or donation after circulatory death donors to meet the demands of the transplant waiting list. Over the past decade, there has been considerable progress in technologies to pre…
View article: Flavin Mononucleotide as a Biomarker of Organ Quality—A Pilot Study
Flavin Mononucleotide as a Biomarker of Organ Quality—A Pilot Study Open
Background. Flavin mononucleotide (FMN), released from damaged mitochondrial complex I during hypothermic liver perfusion, has been shown to be predictive of 90-day graft loss. Normothermic machine perfusion (NMP) and normothermic regional…
View article: Novel delivery of cellular therapy to reduce ischemia reperfusion injury in kidney transplantation
Novel delivery of cellular therapy to reduce ischemia reperfusion injury in kidney transplantation Open
Ex vivo normothermic machine perfusion (NMP) of donor kidneys prior to transplantation provides a platform for direct delivery of cellular therapeutics to optimize organ quality prior to transplantation. Multipotent Adult Progenitor Cells …
Maximizing organs for donation: the potential for <i>ex situ</i> normothermic machine perfusion Open
Currently, there is a shortfall in the number of suitable organs available for transplant resulting in a high number of patients on the active transplant waiting lists worldwide. To address this shortfall and increase the utilization of do…
View article: Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion
Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion Open
BACKGROUND Failed myocardial reperfusion occurs in approximately 50% of patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI). It manifests as microvascular obstruction (MVO…
View article: Novel delivery of cellular therapy to reduce ischaemia reperfusion injury in kidney transplantation
Novel delivery of cellular therapy to reduce ischaemia reperfusion injury in kidney transplantation Open
Ex-vivo normothermic machine perfusion (NMP) of donor kidneys prior to transplantation provides a platform for direct delivery of cellular therapeutics to optimise organ quality prior to transplantation. Multipotent Adult Progenitor Cells …
The Role of miR-200b-3p in Modulating TGF-β1–induced Injury in Human Bronchial Epithelial Cells Open
Background. Dysregulation of microRNAs (miRNAs) has been implicated in airway diseases where transforming growth factor-β (TGF-β)–induced epithelial-mesenchymal transition (EMT) may contribute to pathophysiology. Our study investigated the…
A C‐terminal <span>CXCL</span>8 peptide based on chemokine–glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation Open
Summary Leucocyte recruitment is critical during many acute and chronic inflammatory diseases. Chemokines are key mediators of leucocyte recruitment during the inflammatory response, by signalling through specific chemokine G‐protein‐coupl…