Simin Aysel Florescu
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View article: Fatal Complications in Candida parapsilosis Endocarditis—A Case Report
Fatal Complications in Candida parapsilosis Endocarditis—A Case Report Open
Fungal endocarditis, despite being a rare diagnosis, has a higher morbidity and mortality rate compared to bacterial endocarditis. Candida species are the most common isolated pathogens involved in fungal endocarditis. Diagnosis is suspect…
View article: Infective Endocarditis Associated With Intravenous Drug Use: Clinical Course, Biological Characteristics, and Outcomes of a Romanian Cohort
Infective Endocarditis Associated With Intravenous Drug Use: Clinical Course, Biological Characteristics, and Outcomes of a Romanian Cohort Open
Background Injection drug use is causing a wave of infective endocarditis (IE) worldwide, a severe and potentially deadly infection of the heart's endothelium. While this important public health problem has been well described in Western c…
View article: Clinical and Therapeutic Insights into Sepsis: A Retrospective Observational Study of Inflammatory Markers, and Outcomes
Clinical and Therapeutic Insights into Sepsis: A Retrospective Observational Study of Inflammatory Markers, and Outcomes Open
Introduction: Sepsis is a life-threatening condition caused by dysregulated host responses to infection, leading to organ failure and high mortality. Early recognition, especially in vulnerable populations, remains challenging due to varia…
View article: Characteristics of Infective Endocarditis in Intravenous Drug Users vs. Non-Users: A Retrospective Study Conducted in Bucharest, Romania
Characteristics of Infective Endocarditis in Intravenous Drug Users vs. Non-Users: A Retrospective Study Conducted in Bucharest, Romania Open
Background and Objectives: Infective endocarditis (IE) remains a severe infection with high morbidity and mortality, particularly among people who inject drugs (PWID). Data from Eastern Europe are limited, despite the increasing burden of …
View article: Emergence of Carbapenem-Resistant Klebsiella pneumoniae in a Romanian Infectious Diseases Hospital
Emergence of Carbapenem-Resistant Klebsiella pneumoniae in a Romanian Infectious Diseases Hospital Open
Klebsiella pneumoniae, a member of the Enterobacterales Order, often colonises the gut and causes diverse infections, including bloodstream, urinary, and respiratory infections. The rise in carbapenem-resistant sFtrains, especially those p…
View article: Hybrid, infection- and vaccination-induced protection against laboratory- confirmed SARS-CoV-2 infection in a European multi-centre prospective cohort of healthcare workers, 2021–2024
Hybrid, infection- and vaccination-induced protection against laboratory- confirmed SARS-CoV-2 infection in a European multi-centre prospective cohort of healthcare workers, 2021–2024 Open
Healthcare workers (HCWs) face high occupational exposure to SARS-CoV-2 and are a priority group for vaccination. Both natural infection and vaccination—individually or combined as hybrid immunity—confer protection against SARS-CoV-2 infec…
View article: Aztreonam–avibactam for the treatment of serious infections caused by metallo-β-lactamase-producing Gram-negative pathogens: a Phase 3 randomized trial (ASSEMBLE)
Aztreonam–avibactam for the treatment of serious infections caused by metallo-β-lactamase-producing Gram-negative pathogens: a Phase 3 randomized trial (ASSEMBLE) Open
Background The Phase 3 ASSEMBLE study investigated aztreonam–avibactam versus best available therapy (BAT) for treatment of complicated intra-abdominal infection (cIAI), complicated urinary tract infection (cUTI), hospital-acquired/ventila…
View article: How Common Is Imported Cutaneous Leishmaniasis in Romania? Two Case Reports
How Common Is Imported Cutaneous Leishmaniasis in Romania? Two Case Reports Open
Background: Leishmaniasis is a vector-borne zoonotic disease caused by protozoa of the genus Leishmania. While it is endemic in the Mediterranean Basin and the Balkans, Romania remains a non-endemic country. However, climate change, increa…
View article: Extended Analysis of the Hospitalization Cost and Economic Burden of COVID-19 in Romania
Extended Analysis of the Hospitalization Cost and Economic Burden of COVID-19 in Romania Open
Background/Objectives: COVID-19 has impacted Romania’s healthcare, economy, society, and public health. This study aims to evaluate the financial impact of the COVID-19 pandemic in Romania by analyzing both hospital costs and key elements …
View article: Imported Typhoid Fever in Romania Between 2010 and 2024
Imported Typhoid Fever in Romania Between 2010 and 2024 Open
Background/Objectives: Although a “forgotten” disease in developed countries, typhoid fever remains a significant global health problem, especially in regions with inadequate sanitation and overcrowding. Despite medical advances, this syst…
View article: Prevalence, clinical management, and outcomes of adults hospitalised with endemic arbovirus illness in southeast Europe (MERMAIDS-ARBO): a prospective observational study
Prevalence, clinical management, and outcomes of adults hospitalised with endemic arbovirus illness in southeast Europe (MERMAIDS-ARBO): a prospective observational study Open
For the Greek, Albanian, Romanian, Bosnian, Serbian, and Croatian translation of the summary see Supplementary Materials section.
View article: Multi-antigen serology and a diagnostic algorithm for the detection of arbovirus infections as novel tools for arbovirus preparedness in southeast Europe (MERMAIDS-ARBO): a prospective observational study
Multi-antigen serology and a diagnostic algorithm for the detection of arbovirus infections as novel tools for arbovirus preparedness in southeast Europe (MERMAIDS-ARBO): a prospective observational study Open
For the Greek, Albanian, Romanian, Bosnian, Serbian, and Croatian translation of the summary see Supplementary Materials section.
View article: Non-toxigenic Vibrio cholerae – just another cause of vibriosis or a potential new pandemic?
Non-toxigenic Vibrio cholerae – just another cause of vibriosis or a potential new pandemic? Open
Although nontoxigenic Vibrio cholerae usually stands in the shadow of the two serogroups (O1 and O139) that cause pandemic cholera, its role in human pathology is increasingly recognized and described in the literature. The habitat of thes…
View article: Relative effectiveness of the second booster COVID-19 vaccines against laboratory confirmed SARS-CoV-2 infection in healthcare workers: VEBIS HCW VE cohort study (1 October 2022-2 May 2023)
Relative effectiveness of the second booster COVID-19 vaccines against laboratory confirmed SARS-CoV-2 infection in healthcare workers: VEBIS HCW VE cohort study (1 October 2022-2 May 2023) Open
View article: A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with Klebsiella pneumoniae: Analyzing a Dataset from a Romanian Tertiary Hospital
A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with Klebsiella pneumoniae: Analyzing a Dataset from a Romanian Tertiary Hospital Open
Introduction: The emergence of carbapenem-resistant pathogenic bacteria is a growing global public health concern. Carbapenem-resistant uropathogenic strains of Klebsiella pneumoniae can cause uncomplicated or complicated urinary tract inf…
View article: A Three-Year Analysis of Mortality in Clostridioides difficile Patients in a Tertiary Center
A Three-Year Analysis of Mortality in Clostridioides difficile Patients in a Tertiary Center Open
View article: Incidence of SARS-CoV-2 Infection Among European Healthcare Workers and Effectiveness of the First Booster COVID-19 Vaccine, VEBIS HCW Observational Cohort Study, May 2021–May 2023
Incidence of SARS-CoV-2 Infection Among European Healthcare Workers and Effectiveness of the First Booster COVID-19 Vaccine, VEBIS HCW Observational Cohort Study, May 2021–May 2023 Open
Background: European countries have included healthcare workers (HCWs) among priority groups for COVID-19 vaccination. We established a multi-country hospital network to measure the SARS-CoV-2 incidence and effectiveness of COVID-19 vaccin…
View article: Effectiveness of the autumn 2023 COVID-19 vaccine dose in hospital-based healthcare workers: results of the VEBIS healthcare worker vaccine effectiveness cohort study, seven European countries, season 2023/24
Effectiveness of the autumn 2023 COVID-19 vaccine dose in hospital-based healthcare workers: results of the VEBIS healthcare worker vaccine effectiveness cohort study, seven European countries, season 2023/24 Open
COVID-19 vaccination recommendations include healthcare workers (HCWs). We measured COVID-19 vaccine effectiveness (CVE) of the autumn 2023 dose against laboratory-confirmed SARS-CoV-2 infection in a prospective cohort study of 1,305 HCWs …
View article: The Interplay of Chronic Hepatitis C and COVID-19: Implications for Prognosis and Treatment
The Interplay of Chronic Hepatitis C and COVID-19: Implications for Prognosis and Treatment Open
Introduction Chronic hepatitis C (CHC) remains a significant public health concern due to both hepatic and extrahepatic manifestations associated with substantial morbidity and mortality. The emergence of SARS-CoV-2 has raised concerns abo…
View article: Identifying risk factors for blood culture negative infective endocarditis: An international ID-IRI study
Identifying risk factors for blood culture negative infective endocarditis: An international ID-IRI study Open
View article: Risk factors for bloodstream infections due to carbapenem-resistant Enterobacterales: a nested case-control-control study
Risk factors for bloodstream infections due to carbapenem-resistant Enterobacterales: a nested case-control-control study Open
Background Carbapenem-resistant Enterobacterales (CRE) bloodstream infections (BSIs) are a major threat to patients. To date, data on risk factors have been limited, with low internal and external validity. In this multicentre study, risk …
View article: The Prevalence of Depression and Its Potential Link to Liver Fibrosis in Patients Diagnosed With Chronic Hepatitis C Virus Infection Prior to the Initiation of Direct-Acting Antiviral Treatment
The Prevalence of Depression and Its Potential Link to Liver Fibrosis in Patients Diagnosed With Chronic Hepatitis C Virus Infection Prior to the Initiation of Direct-Acting Antiviral Treatment Open
Introduction Chronic hepatitis C virus (HCV) infection is associated with various extrahepatic manifestations, including depression. This study aimed to determine the prevalence of depression in treatment-naive HCV patients and explore its…
View article: Carbapenem-Resistant NDM and OXA-48-like Producing K. pneumoniae: From Menacing Superbug to a Mundane Bacteria; A Retrospective Study in a Romanian Tertiary Hospital
Carbapenem-Resistant NDM and OXA-48-like Producing K. pneumoniae: From Menacing Superbug to a Mundane Bacteria; A Retrospective Study in a Romanian Tertiary Hospital Open
Background: Carbapenem-resistant Klebsiella pneumoniae (Cr-Kpn) is becoming a growing public health problem through the failure of adequate treatment. This study’s objectives are to describe the sources of Cr-Kpn in our hospital over 22 mo…
View article: Blood Culture Negative Endocarditis; What Do Concurrent Cardiac Disorders Tell Us?
Blood Culture Negative Endocarditis; What Do Concurrent Cardiac Disorders Tell Us? Open
Purpose: Blood culture negative endocarditis (BCNE) presents diagnostic challenges, necessitating precise identification of high-risk patient cohorts. Hence, our objective was to pinpoint high-risk cohorts for BCNE. Methods: The study incl…
View article: Results of Response-Guided Therapy with Pegylated Interferon Alpha 2a in Chronic Hepatitis B and D
Results of Response-Guided Therapy with Pegylated Interferon Alpha 2a in Chronic Hepatitis B and D Open
Pegylated interferon alpha 2a continues to be used for the treatment of chronic hepatitis D. The reported on-treatment virologic response varies between 17 and 47%, with relapses in more than 50% of these patients. No stopping rules have b…
View article: Non-toxigenic Corynebacterium diphtheriae cutaneous infections among two injecting drug-users with HIV/Tuberculosis coinfection from Bucharest, Romania
Non-toxigenic Corynebacterium diphtheriae cutaneous infections among two injecting drug-users with HIV/Tuberculosis coinfection from Bucharest, Romania Open
View article: Upsurge in cases of travellers’ malaria ex Zanzibar indicates that malaria is on the rebound in the archipelago
Upsurge in cases of travellers’ malaria ex Zanzibar indicates that malaria is on the rebound in the archipelago Open
View article: Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA)
Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA) Open
CRE infections are associated with significant attributable mortality and increased adjusted hazard of mortality when compared with CSE infections or patients without infection. Underlying patient characteristics and a delay in appropriate…
View article: Intestinal protozoa in returning travellers: a GeoSentinel analysis from 2007 to 2019
Intestinal protozoa in returning travellers: a GeoSentinel analysis from 2007 to 2019 Open
Background Prolonged diarrhoea is common amongst returning travellers and is often caused by intestinal protozoa. However, the epidemiology of travel-associated illness caused by protozoal pathogens is not well described. Methods We analys…
View article: Novel Tools for Arbovirus Preparedness: The Use of Multi-Antigen Serology for Detection of Arbovirus Infections
Novel Tools for Arbovirus Preparedness: The Use of Multi-Antigen Serology for Detection of Arbovirus Infections Open