Explanipedia

Amino acid sensing in cancer Open

Shiwei Duan, Lihong He, Jiawei Wang, Hanjia Zhang, Simin Yao , et al. · 2025

Tumour progression is accompanied by metabolic reprogramming, enabling adaptation to the nutrient-deprived microenvironment. Amino acids, as key metabolic substrates, play a central role in metabolic reprogramming. Beyond their conventiona…

Construction And Application Of A Peri-Implant Tissue-On-Chip Open

Mengmeng Lu, Simin Yao, Zhenyu Sun, Yue Hu, Gu Yangqian · 2025

Aim or purpose: This study aimed to develop a a biomimetic microfluidic model of peri-implant soft tissue, recapitulating basement membrane formation and enabling investigation of oral inflammation, immune responses, and tissue regeneratio…

Nets Inhibition For Peri-Implantitis Via Microenvironment Modulation-Based Nanoparticles Open

Mengmeng Lu, Yue Hu, Zhenyu Sun, Yanhong Gu, Simin Yao , et al. · 2025

Aim or purpose: This study aimed to validate the efficacy of a novel nano-based drug delivery system in targeting suppression of neutrophil extracellular traps (NETs) release with an organ-on-chip model of peri-implant soft tissue, and to …

Artificial Intelligence-Assisted Analysis Of Plaque-Induced Peri-Implant Diseases Open

Mengmeng Lu, Zhenyu Sun, Simin Yao, Yue Hu · 2025

Aim or purpose: The study aims to develop an AI-deep learning model for effcient intraoral plaque monitoring in dental implant patients and investigate plaque characteristics' correlation with clinical parameters to establish plaque as a p…

Urinary Bladder Matrix as a Guide Bone Regeneration Barrier Membrane for Inhibiting Cell Invasion and Promoting Bone Formation Open

Jie Zhong, Zhaoxin Chen, Yanhong Gu, Yiwen Xu, Wenyue Cheng , et al. · 2025

Natural resorbable collagen membranes are widely used in guided bone regeneration (GBR) in oral implantology and prosthodontics. However, the rapid degradation and inadequate mechanical properties raise concerns about potentially compromis…

Effects of SGLT2 inhibitors on cognitive impairment in elderly inpatients with heart failure with reduced ejection fraction: a prospective cohort study Open

Jiaying Li, Xiaoyan Wang, Qianwei Zheng, Jing Tian, Huanzhen Chen , et al. · 2025

Elevated protein lactylation promotes immunosuppressive microenvironment and therapeutic resistance in pancreatic ductal adenocarcinoma Open

Kang Sun, Xiaozhen Zhang, Jiatao Shi, Jinyan Huang, Sicheng Wang , et al. · 2025

Metabolic reprogramming shapes the tumor microenvironment (TME) and may lead to immunotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Elucidating the impact of pancreatic cancer cell metabolism in the TME is essential to the…

Quality Characteristics and Volatile Components of Chili Oil Prepared from the Combination of Shuanla and Erjingtiao Peppers Open

Fang Yang, Simin Yao, Haibin Yuan, Can Yuan, Hongfeng Jia · 2024

This study aimed to investigate the influence of varying weight ratios of Shuanla and Erjingtiao peppers (10:0, 8:2, 6:4, 5:5, 4:6, 2:8, and 0:10, corresponding to samples PA, PB, PC, PD, PE, PF, and PG, respectively) on the sensory attrib…

Abnormal eNK cells contribute to endometrial fibrosis in intrauterine adhesions patients Open

Zhenhua Zhou, Qiao Weng, Dan Liu, Simin Yao, Xueqin Zou , et al. · 2024

Endometrial natural killer cells (eNK) at the proliferative phase are one of the major lymphocytes in the endometrium, but their phenotype and function remain elucidated. Here, we demonstrated that eNK cells had three subtypes and were dif…

Effects of Sglt2 Inhibitors on Cognitive Impairment in Elderly Inpatients with Heart Failure with Reduced Ejection Fraction: A Prospective Cohort Study Open

Jiaying Li, Xiaoyan Wang, Qianwei Zheng, Jing Tian, Huanzhen Chen , et al. · 2024

Targeting <span>CD301</span> <sup>+</sup> macrophages inhibits endometrial fibrosis and improves pregnancy outcome Open

Haining Lv, Haixiang Sun, Limin Wang, Simin Yao, Dan Liu , et al. · 2023

Macrophages are a key and heterogeneous cell population involved in endometrial repair and regeneration during the menstrual cycle, but their role in the development of intrauterine adhesion (IUA) and sequential endometrial fibrosis remain…

Targeting CD301+ macrophage inhibits endometrial fibrosis and improves pregnancy outcome Open

Haining Lv, Haixiang Sun, Limin Wang, Simin Yao, Dan Liu , et al. · 2023

Macrophages are a key and heterogeneous cell population involved in endometrial repair and regeneration during the menstrual cycle, but their role in the development of intrauterine adhesion (IUA) and sequential endometrial fibrosis remain…

Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions Open

Zhenhua Zhou, Huiyan Wang, Xiwen Zhang, Minmin Song, Simin Yao , et al. · 2022

Intrauterine adhesions (IUA), characterized by endometrial fibrosis, is a common cause of uterine infertility. We previously demonstrated that partial epithelial-mesenchymal transition (EMT) and the loss of epithelial homeostasis play a vi…

Deciphering the endometrial niche of human thin endometrium at single-cell resolution Open

Haining Lv, Guangfeng Zhao, Peipei Jiang, Huiyan Wang, Zhiyin Wang , et al. · 2022

Significance Thin endometrium is the most common reason for uterine infertility and refractory gynecological diseases due to its complexity in pathogenesis and adverse pregnancy outcomes. Here, we profile cells from normal and thin endomet…

Down-regulation of PBK inhibits proliferation of human endometrial stromal cells in thin endometrium Open

Qi Zhu, Simin Yao, Yishan Dong, Dan Liu, Huiyan Wang , et al. · 2022

Additional file 1 of Down-regulation of PBK inhibits proliferation of human endometrial stromal cells in thin endometrium Open

Qi Zhu, Simin Yao, Yishan Dong, Dan Liu, Huiyan Wang , et al. · 2022

Additional file 1: Supplementary Figure 1. Enrichment analysis of differentially expressed genes. Functional enrichment analysis of the up- and downregulated DEGs, including GO category cellular components (A), and molecular function (B). …

Urinary 8-OxoGsn as a Potential Indicator of Mild Cognitive Impairment in Frail Patients With Cardiovascular Disease Open

Simin Yao, Peipei Zheng, Wei He, Jian‐Ping Cai, Hua Wang , et al. · 2021

Oxidative RNA damage has been found to be associated with age-related diseases and 8-oxo-7,8-dihydroguanosine (8-oxoGsn) is a typical marker of oxidative modification of RNA. Urine tests are a feasible non-invasive diagnostic modality. The…

Urinary 8-OxoGsn as A Potential Indicator of Mild Cognitive Impairment in Frail Patients With Cardiovascular Disease Open

Simin Yao, Peipei Zheng, Ning Sun, Jian‐Ping Cai, Hua Wang , et al. · 2021

Background Oxidative RNA damage has been found to be associated with age-related diseases and 8-oxo-7,8-dihydroguanosine (8-oxoGsn) is a typical marker of oxidative modification of RNA. We aimed to assess whether the measurement of urinary…

circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis Open

Minmin Song, Guangfeng Zhao, Haixiang Sun, Simin Yao, Zhenhua Zhou , et al. · 2021

Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases including organ fibrosis. Endometrium fibrosis is the leading cause of uterine infertility, but the role…

Author response: circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis Open

Minmin Song, Guangfeng Zhao, Haixiang Sun, Simin Yao, Zhenhua Zhou , et al. · 2021

Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Emerging evidence demonstrates the importa…

Prevalence and Prognostic Value of Heart Failure Stages: An Elderly Inpatient Based Cohort Study Open

Peipei Zheng, Simin Yao, Di Guo, Lingling Cui, Guobin Miao , et al. · 2021

Background: The prevalence and prognostic value of heart failure (HF) stages among elderly hospitalized patients is unclear. Methods: We conducted a prospective, observational, multi-center, cohort study, including hospitalized patients wi…

Targeting circPTPN12/miR-21-5p/ΔNp63α pathway as a therapeutic strategy for human endometrial fibrosis Open

Minmin Song, Guangfeng Zhao, Haixiang Sun, Simin Yao, Zhenhua Zhou , et al. · 2021

Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases including organ fibrosis. Endometrium fibrosis is the leading cause of uterine infertility, but the role…

Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease [Corrigendum] Open

Wei He, Yao Luo, Junpeng Liu, Ning Sun, Di Guo , et al. · 2021

[This corrects the article DOI: 10.2147/CIA.S270887.].

Frailty related all-cause mortality or hospital readmission among adults aged 65 and older with stage-B heart failure inpatients Open

Peipei Zheng, Simin Yao, Wei He, Yuhao Wan, Hua Wang , et al. · 2021

Adding high-sensitivity C-reactive protein to frailty assessment to predict mortality and cardiovascular events in elderly inpatients with cardiovascular disease Open

Simin Yao, Peipei Zheng, Yuhao Wan, Wei Dong, Guobin Miao , et al. · 2021

ChiCTR1800017204; date of registration: 07/18/2018. URL: http://www.chictr.org.cn/showproj.aspx?proj=28931.

Prevalence and Prognostic Significance of Frailty in Gerontal Inpatients With Pre-clinical Heart Failure: A Subgroup Analysis of a Prospective Observational Cohort Study in China Open

Peipei Zheng, Simin Yao, Jing Shi, Yuhao Wan, Di Guo , et al. · 2020

Objective: To evaluate the prognostic value of frailty in gerontal pre-clinical heart failure (stage B heart failure, SBHF) inpatients. Background: The association between frailty and SBHF remains unknown. Methods: We conducted a subgroup …

HMGA2-induced epithelial–mesenchymal transition is reversed by let-7d in intrauterine adhesions Open

Minmin Song, Chenrui Cao, Zhenhua Zhou, Simin Yao, Peipei Jiang , et al. · 2020

Intrauterine adhesions (IUAs), the leading cause of uterine infertility, are characterized by endometrial fibrosis. The management of IUA is challenging because the pathogenesis of the disease largely unknown. In this study, we demonstrate…

The effect of comprehensive assessment and multi-disciplinary management for the geriatric and frail patient Open

Simin Yao, Peipei Zheng, Liwei Ji, Zhao Ma, Lijuan Wang , et al. · 2020

Chinese Clinical Trials Register, ChiCTR1900022623. Registered on April 19, 2019, http://www.chictr.org.cn/showproj.aspx?proj=38141.

The Efficacy of the Comprehensive Assessment and Multi-Disciplinary Management of Geriatric and Frail Patients: The Study Protocol of a Multi-Center, Randomized, Parallel Controlled Trial (MDT-F) Open

Simin Yao, Peipei Zheng, Liwei Ji, Zhao Ma, Lijuan Wang , et al. · 2020

Background: A comprehensive geriatric assessment (CGA) of elderly patients is useful for detecting the patients' vulnerabilities. Exercise and early rehabilitation, nutritional intervention, traditional Chinese medicine (TCM), standardized…

Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease Open

Wei He, Yao Luo, Junpeng Liu, Ning Sun, Di Guo , et al. · 2020

Elevated circulating TMAO levels are independently associated with frailty among older adults with cardiovascular disease.

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