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View article: Polarization MultiFocus Microscopy for volumetric super-resolution and orientation imaging of biofilaments
Polarization MultiFocus Microscopy for volumetric super-resolution and orientation imaging of biofilaments Open
Accessing molecular orientation in single molecule localization microscopy (SMLM) offers valuable insights into molecular ordering and organization in biological structures. Conventional single-molecule orientation-localization microscopy …
View article: Coupling of protein condensates to ordered lipid domains determines functional membrane organization
Coupling of protein condensates to ordered lipid domains determines functional membrane organization Open
During T cell activation, the transmembrane adaptor protein LAT (linker for activation of T cells) forms biomolecular condensates with Grb2 and Sos1, facilitating signaling. LAT has also been associated with cholesterol-rich condensed lipi…
View article: Coupling of protein condensates to ordered lipid domains determines functional membrane organization
Coupling of protein condensates to ordered lipid domains determines functional membrane organization Open
During T-cell activation, the transmembrane adaptor Linker of Activation of T-cells (LAT) forms biomolecular condensates with Grb2 and Sos1, facilitating signaling. LAT has also been associated with cholesterol-rich condensed lipid domains…
View article: Single Molecule Measurements of the Accessibility of Molecular Surfaces
Single Molecule Measurements of the Accessibility of Molecular Surfaces Open
An important measure of the conformation of protein molecules is the degree of surface exposure of its specific segments. However, this is hard to measure at the level of individual molecules. Here, we combine single molecule photobleachin…
View article: Altered Membrane Mechanics Provides a Receptor‐Independent Pathway for Serotonin Action
Altered Membrane Mechanics Provides a Receptor‐Independent Pathway for Serotonin Action Open
Serotonin, an important signaling molecule in humans, has an unexpectedly high lipid membrane affinity. The significance of this finding has evoked considerable speculation. Here we show that membrane binding by serotonin can directly modu…
View article: Serotonin Alters the Phase Equilibrium of a Ternary Mixture of Phospholipids and Cholesterol
Serotonin Alters the Phase Equilibrium of a Ternary Mixture of Phospholipids and Cholesterol Open
Unsaturated and saturated phospholipids tend to laterally segregate, especially in the presence of cholesterol. Small molecules such as neurotransmitters, toxins, drugs etc. possibly modulate this lateral segregation. The small aromatic ne…
View article: Receptor-independent membrane mediated pathways of serotonin action
Receptor-independent membrane mediated pathways of serotonin action Open
Serotonin is a neurotransmitter as well as a somatic signaling molecule, and the serotonergic system is a major target for psychotropic drugs. Serotonin, together with a few related neurotransmitters, has recently been found to exhibit an …
View article: Ordered and Disordered Segments of Amyloid‐β Drive Sequential Steps of the Toxic Pathway
Ordered and Disordered Segments of Amyloid‐β Drive Sequential Steps of the Toxic Pathway Open
While the roles of intrinsically disordered protein domains in driving many interactions are increasingly well‐appreciated, the mechanism of toxicity of disease‐causing disordered proteins remains poorly understood. A prime example is Alzh…