Explanipedia

MR Pulse Sequences for Parathyroid Adenoma Imaging Using [18F]fluorocholine PET/MR in Primary Hyperparathyroidism Open

Shaza K. Isenschmid, Jan A. Schaab, Antonio Giulio Gennari, Junko Inukai, Grégoire B. Morand , et al. · 2025

Purpose Currently, no standardized anatomic magnetic resonance (MR) imaging protocol exists for detecting parathyroid adenomas. We analyzed various MR pulse sequences to evaluate their performance in visualizing histopathologically confirm…

Use of the tracheal bisecting line to differentiate upper pole from lower pole parathyroid adenomas: a PET/MR study using [18F]Fluorocholine Open

Junko Inukai, Bert-Ram Sah, Stephan Beintner-Skawran, Alexander Maurer, Simon A. Mueller , et al. · 2025

Purpose Accurate preoperative localization of parathyroid adenomas is crucial in managing primary hyperparathyroidism (pHPT). Although [ 18 F]Fluorocholine PET/CT and PET/MR have shown superior sensitivity over conventional imaging, distin…

CTCF Binding Site Mutations: Linking Topologically Associated Domains Dysregulation to Cutaneous Squamous Cell Carcinoma Progression Open

Amarinder Singh Thind, Bruce Ashford, Nicholas B. Shannon, Dario Strbenac, A. Piper , et al. · 2025

Background Cutaneous squamous cell carcinoma (cSCC) is the most common lethal malignancy with metastatic potential. The high mutational burden in cSCC has made it difficult to understand the significance of variants in the noncoding and re…

Effect of metformin on hypoxia-associated gene expression in oral cavity squamous cell carcinoma in non-diabetic patients - a prospective window of opportunity study Open

Simon A. Mueller, Olgun Eliçin, Bastien Monney, Tilman T. Rau, Alan Dal Pra , et al. · 2025

Purpose Research suggests that metformin may reduce tumor hypoxia, rendering it a potential radiosensitizer. This study investigated metformin’s effect on hypoxia-associated gene expression in oral cavity squamous cell carcinoma (OCSCC). M…

[18F]Fluorocholine PET/MRI and [18F]Fluorocholine PET/CT as first- and second-line imaging in primary hyperparathyroidism – who takes the lead? Open

Petra Petranović Ovčariček, Jan Schaab, Stephan Beintner-Skawran, Alexander Maurer, Niels J. Rupp , et al. · 2025

PET/MR for predicting extranodal extension of head and neck cancer Open

V. Pineda Sánchez, Daniele Antonio Pizzuto, Alexander Maurer, Urs J. Muehlematter, Bert-Ram Sah , et al. · 2025

Purpose To analyze the diagnostic accuracy of multiparametric FDG-PET/MR in identifying pathologic extranodal extension (pENE) of lymph node metastases (LNM) in head and neck squamous cell carcinoma (HNSCC) patients. Methods and materials …

DeintensiF: Standard versus individualized deintensified follow-up after curative treatment in head and neck cancer: protocol of a randomized pilot study Open

Martin Mueller, Miranda Visini, Simon A. Mueller, Thomas Städler, Gunesh P. Rajan , et al. · 2025

Background Around 70% of head and neck cancer (HNC) cases are diagnosed in an advanced stage. Improvements in treatment have led to a cure rate of up to 80–90% for early-stage and 40–50% for advanced-stage disease. However, routine follow-…

A Pilot Trial of Tongue Reconstruction Using the Chimeric Innervated Vastus Lateralis Muscle and Antero‐Lateral Thigh Free Flap Open

Emma Charters, Jessica Boehm, Anita Macdonald D'Silva, Raymond Wu, Simon A. Mueller , et al. · 2025

Background Subtotal and total glossectomies for advanced tongue cancer result in significant speech‐ and swallow‐related morbidity, impairing quality of life. This prospective pilot study compares the safety and functional outcomes associa…

Long-Term Persistence of Glycemic Dysregulation in Patients With a History of Pheochromocytoma/Paraganglioma Open

Alessa Fischer, Hanna Remde, Christina Pamporaki, Ulrich Dischinger, Nicole Bechmann , et al. · 2025

Context Pheochromocytomas and paragangliomas (PPGLs) are rare endocrine tumors that frequently produce catecholamines. Catecholamine-induced cardiometabolic complications substantially contribute to increased morbidity and mortality in PPG…

Outcome-oriented clinicopathological reappraisal of sinonasal adenoid cystic carcinoma with broad morphological spectrum and high MYB::NFIB prevalence Open

Tina Mauthe, Christian M. Meerwein, David Holzmann, Michael B. Soyka, Simon A. Mueller , et al. · 2024

Molecular analysis using SalvGlandDx improves risk of malignancy estimation and diagnosis of salivary gland cytopathology: An exploratory multicenter study Open

Sandra N. Freiberger, Kristian Ikenberg, Demi van Egmond, Sofie Claerhout, Tom van Wezel , et al. · 2024

Background Diagnosis of salivary gland neoplasms is challenging, especially on cytological specimens acquired by fine‐needle aspiration. The recently implemented standardized Milan system for reporting salivary gland cytopathology provides…

Oncologic outcome with versus without target volume compartmentalization in postoperative radiotherapy for oral cavity squamous cell carcinoma Open

Elena Riggenbach, M. Waser, Simon A. Mueller, Daniel M. Aebersold, Roland Giger , et al. · 2024

Background and purpose The volume treated with postoperative radiation therapy (PORT) in patients with oral cavity squamous cell carcinoma (OCSCC) is a mediator of toxicity affecting quality of life. Current guidelines only allow for very …

Sinonasal mucosal melanoma treatment response assessment to immune checkpoint inhibitors using hybrid positron emission tomography imaging Open

Alexander Maurer, Nathalie A. Gstrein, Florentia Dimitriou, Thomas Sartoretti, Jan A. Schaab , et al. · 2023

Overall and disease-specific survival of sinonasal adenoid cystic carcinoma: a systematic review and meta-analysis Open

Tina Mauthe, David Holzmann, Michael B. Soyka, Simon A. Mueller, Panagiotis Balermpas , et al. · 2023

This meta-analysis aims to investigate the outcome of sinonasal adenoid cystic carcinoma (snAdCC). We followed PRISMA guidelines and included studies reporting 5-year overall survival (OS) rates for snAdCC. Eligible studies were identified…

Risk Factors for Fear of Recurrence in Head and Neck Cancer Patients Open

Julia Riggauer, Daniela Blaser, Olgun Eliçin, Brigitta Gahl, Roland Giger , et al. · 2022

Objective Fear of recurrence (FoR) affects the quality of life of head and neck cancer survivors. Identification of factors predisposing to FoR may help to recognize and treat patients at risk. Materials and Methods For this exploratory st…

Whole genome analysis reveals the genomic complexity in metastatic cutaneous squamous cell carcinoma Open

Amarinder Singh Thind, Bruce Ashford, Dario Strbenac, Jenny Mitchell, Jenny Lee , et al. · 2022

Metastatic cutaneous squamous cell carcinoma (CSCC) is a highly morbid disease requiring radical surgery and adjuvant therapy, which is associated with a poor prognosis. Yet, compared to other advanced malignancies, relatively little is kn…

Cancer Progression Gene Expression Profiling Identifies the Urokinase Plasminogen Activator Receptor as a Biomarker of Metastasis in Cutaneous Squamous Cell Carcinoma Open

Elahe Minaei, Simon A. Mueller, Bruce Ashford, Amarinder Singh Thind, Jenny Mitchell , et al. · 2022

Cutaneous squamous cell carcinoma (cSCC) of the head and neck region is the second most prevalent skin cancer, with metastases to regional lymph nodes occurring in 2%–5% of cases. To further our understanding of the molecular events charac…

Association of Multiprofessional Preoperative Assessment and Information for Patients With Head and Neck Cancer With Postoperative Outcomes Open

Manuela Schmid, Roland Giger, Lluís Nisa, Simon A. Mueller, Maria Schubert , et al. · 2022

The results of this case-control study suggest that MUPAID for patients who are undergoing complex oncologic HNC surgery is associated with shortened LOS and costs per case as well as decreased complications severity. These results are pro…

Whole genome analysis reveals the genomic complexity in metastatic cutaneous squamous cell carcinoma Open

Amarinder Singh Thind, Bruce Ashford, Dario Strbenac, Ruta Gupta, Jonathan R. Clark , et al. · 2022

Metastatic cutaneous squamous cell carcinoma (cSCC) is a highly morbid disease requiring radical surgery and adjuvant therapy that is associated with reduced overall survival. Yet compared to other advanced malignancies, relatively little …

Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma Open

Timothy J. Eviston, Elahe Minaei, Simon A. Mueller, Navid Ahmadi, Bruce Ashford , et al. · 2021

Gene Expression Profiling Of Perineural Invasion In Head And Neck Cutaneous Squamous Cell Carcinoma Open

Timothy J. Eviston, Elahe Minaei, Simon A. Mueller, Navid Ahmadi, Bruce Ashford , et al. · 2021

Perineural invasion (PNI) is frequently associated with aggressive clinical behaviour in head and neck cutaneous squamous cell carcinoma (HNcSCC) leading to local recurrence and treatment failure. This study evaluates the gene expression p…

Beyond the coding genome in metastatic cutaneous squamous cell carcinoma Open

Amarinder Singh Thind, Bruce Ashford, Dario Strbenac, Ruta Gupta, Jonathan R. Clark , et al. · 2021

Molecular patterns in salivary duct carcinoma identify prognostic subgroups Open

Simon A. Mueller, Marie Gauthier, James Blackburn, John P. Grady, Spiridoula Kraitsek , et al. · 2020

Development and validation of a targeted gene sequencing panel for application to disparate cancers Open

Mark J. McCabe, Marie Gauthier, Chia-Ling Chan, Tanya Thompson, Sunita M C De Sousa , et al. · 2019

Effect of preoperative immunonutrition on complications after salvage surgery in head and neck cancer Open

Simon A. Mueller, Catherine Mayer, Beat Bojaxhiu, Carla Aeberhard, Philipp Schüetz , et al. · 2019

Background Patients undergoing salvage surgery for recurrent head and neck squamous cell carcinoma are at high risk of postoperative complications due to the adverse effects of radiotherapy on wound healing. Malnutrition is an additional r…

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