Simon Alesi
YOU?
Author Swipe
View article: Diet and female fertility: a population-based study re-evaluating the need for prescriptive dietary patterns
Diet and female fertility: a population-based study re-evaluating the need for prescriptive dietary patterns Open
Introduction Diet may impact female fertility via inflammatory pathways, but the value of specific anti-inflammatory dietary indices compared with general healthy eating guidelines is unclear. We examined associations between different mea…
View article: Preconception lifestyle interventions for women—a systematic review and meta-analysis of intervention characteristics and behaviour change techniques
Preconception lifestyle interventions for women—a systematic review and meta-analysis of intervention characteristics and behaviour change techniques Open
BACKGROUND The time before conception is an important opportunity to improve maternal lifestyle, and hence improve fertility and health. However, the components of effective preconception lifestyle interventions are unclear. OBJECTIVE AND …
View article: Metabolic associations of human placental lactogen in pregnancies at high metabolic risk: An observational cohort study
Metabolic associations of human placental lactogen in pregnancies at high metabolic risk: An observational cohort study Open
Introduction Human placental lactogen (hPL) is a placental hormone which, according to preclinical research, appears to have key metabolic roles in pregnancy. We aimed to examine pregnancy hPL levels in relation to maternal metabolic param…
View article: Exploring Causal Associations Between Serum Inflammatory Markers and Female Reproductive Disorders: A Mendelian Randomisation Study
Exploring Causal Associations Between Serum Inflammatory Markers and Female Reproductive Disorders: A Mendelian Randomisation Study Open
Although inflammation may disrupt immunoendocrine crosstalk essential for female reproductive function, causal links to disorders like polycystic ovary syndrome (PCOS) and endometriosis remain unestablished. This study aimed to utilise Men…
View article: Blood-based inflammatory markers in female infertility: evidence from Mendelian randomization analysis
Blood-based inflammatory markers in female infertility: evidence from Mendelian randomization analysis Open
This is the first study to examine causal relationships between inflammation and female infertility using MR. Monocyte chemoattractant protein-1 and interleukin-8 are implicated in anovulatory infertility; however, only the relationship wi…
View article: Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies
Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies Open
Preconception diet is a proposed modifiable risk factor for infertility (1) . However, there is no official guidance for women in the preconception period as to which dietary approaches may improve fertility. A comprehensive synthesis of t…
View article: The effectiveness and safety of lifestyle medicine and integrative therapies in inflammatory arthritis: an umbrella review using a hierarchical evidence gathering approach
The effectiveness and safety of lifestyle medicine and integrative therapies in inflammatory arthritis: an umbrella review using a hierarchical evidence gathering approach Open
Objective An umbrella review was conducted to provide a comprehensive evaluation of the evidence on lifestyle medicine and integrative therapies for inflammatory arthritis. Methods Five electronic databases were searched for umbrella revie…
View article: Assessing the influence of preconception diet on male fertility: a systematic scoping review
Assessing the influence of preconception diet on male fertility: a systematic scoping review Open
BACKGROUND The last decade has seen increased research on the relationship between diet and male fertility, but there are no clearly defined nutritional recommendations for men in the preconception period to support clinical fertility outc…
View article: Effects of different insulin sensitisers in the management of polycystic ovary syndrome: A systematic review and meta‐analysis
Effects of different insulin sensitisers in the management of polycystic ovary syndrome: A systematic review and meta‐analysis Open
Objective Characteristic features of polycystic ovary syndrome (PCOS) include insulin resistance and an increased risk for type 2 diabetes. To promote improved insulin sensitivity, insulin sensitisers have been used in PCOS. However, direc…
View article: Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome
Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome Open
This effort was primarily funded by the Australian Government via the National Health Medical Research Council (NHMRC) (APP1171592), supported by a partnership with American Society for Reproductive Medicine, Endocrine Society, European So…
View article: Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome
Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome Open
STUDY QUESTION What is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference? SUMMARY ANSWER International evidence-based…
View article: Efficacy and safety of anti-androgens in the management of polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials
Efficacy and safety of anti-androgens in the management of polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials Open
National Health and Medical Research Council (NHMRC) of Australia Monash University.
View article: Metformin and Combined Oral Contraceptive Pills in the Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis
Metformin and Combined Oral Contraceptive Pills in the Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis Open
Context Polycystic ovary syndrome (PCOS) affects more than 1 in 10 women. Objective As part of the 2023 International PCOS Guidelines update, comparisons between combined oral contraceptive pills (COCP), metformin, and combination treatmen…
View article: The impact of metformin with or without lifestyle modification versus placebo on polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials
The impact of metformin with or without lifestyle modification versus placebo on polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials Open
Objective Available evidence has shown that metformin improves insulin sensitivity and weight management in polycystic ovary syndrome (PCOS). Nevertheless, key knowledge gaps remain regarding its efficacy and the specific outcomes in this …
View article: Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome
Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome Open
Study question What is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference? Summary answer International evidence-based…
View article: Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies
Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies Open
BACKGROUND Preconception diet is a proposed modifiable risk factor for infertility. However, there is no official guidance for women in the preconception period as to which dietary approaches may improve fertility. OBJECTIVE AND RATIONALE …
View article: Different kinds of oral contraceptive pills in polycystic ovary syndrome: a systematic review and meta-analysis
Different kinds of oral contraceptive pills in polycystic ovary syndrome: a systematic review and meta-analysis Open
Objective To compare between different combined oral contraceptive pills (COCPs) as part of the update of the International Evidence-Based Guidelines on the Assessment and Management of polycystic ovary syndrome (PCOS). Design A systematic…
View article: Can Dietary Patterns Impact Fertility Outcomes? A Systematic Review and Meta-Analysis
Can Dietary Patterns Impact Fertility Outcomes? A Systematic Review and Meta-Analysis Open
There are conflicting results on the effect of diet on fertility. This study aimed to assess the effect of different dietary patterns on fertility outcomes in populations who conceive spontaneously and those requiring assisted reproductive…
View article: Combined oral contraceptive pill compared with no medical treatment in the management of polycystic ovary syndrome: A systematic review
Combined oral contraceptive pill compared with no medical treatment in the management of polycystic ovary syndrome: A systematic review Open
Objective As part of the update of the International Evidence‐Based Guidelines for the Assessment and Management of polycystic ovary syndrome (PCOS), a systematic review was performed to inform evidence‐based recommendations. Design System…
View article: Anti-Inflammatory Diets in Fertility: An Evidence Review
Anti-Inflammatory Diets in Fertility: An Evidence Review Open
Infertility is a global health concern affecting 48 million couples and 186 million individuals worldwide. Infertility creates a significant economic and social burden for couples who wish to conceive and has been associated with suboptima…
View article: Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome.
Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome. Open
Polycystic ovary syndrome (PCOS) affects 1 in 5 women of reproductive age, and is characterized by menstrual irregularities, clinical or biochemical hyperandrogenism, and the presence of polycystic ovary morphology. One of the recommended …
View article: Efficacy and Safety of Nutrient Supplements for Glycaemic Control and Insulin Resistance in Type 2 Diabetes: An Umbrella Review and Hierarchical Evidence Synthesis
Efficacy and Safety of Nutrient Supplements for Glycaemic Control and Insulin Resistance in Type 2 Diabetes: An Umbrella Review and Hierarchical Evidence Synthesis Open
Background: Nutrient supplements are widely used for type 2 diabetes (T2D), yet evidence-based guidance for clinicians is lacking. Methods: We searched the four electronic databases from November 2015–December 2021. The most recent, most c…
View article: Efficacy and Safety of Nutrient Supplements for Glycemic Control and Insulin Resistance in Type 2 Diabetes: An Umbrella Review and Hierarchical Evidence Synthesis
Efficacy and Safety of Nutrient Supplements for Glycemic Control and Insulin Resistance in Type 2 Diabetes: An Umbrella Review and Hierarchical Evidence Synthesis Open
Background: Nutrient supplements are widely used for type 2 diabetes (T2D) yet evidence-based guidance for clinicians is lacking. Methods: We searched the four electronic databases from November 2015–December 2021. The most recent, m…
View article: Vitamin D and COVID-19: An Overview of Recent Evidence
Vitamin D and COVID-19: An Overview of Recent Evidence Open
The novel coronavirus severe acute respiratory syndrome (SARS-CoV-2) has progressed rapidly from an outbreak to a global pandemic, with new variants rapidly emerging. Coronavirus disease 2019 (COVID-19), the disease resulting from SARS-CoV…
View article: Metabolomic Biomarkers in Gestational Diabetes Mellitus: A Review of the Evidence
Metabolomic Biomarkers in Gestational Diabetes Mellitus: A Review of the Evidence Open
Gestational diabetes mellitus (GDM) is the fastest growing type of diabetes, affecting between 2 to 38% of pregnancies worldwide, varying considerably depending on diagnostic criteria used and sample population studied. Adverse obstetric o…