André Simon
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View article: MOUFLON: Multi-group Modularity-based Fairness-aware Community Detection
MOUFLON: Multi-group Modularity-based Fairness-aware Community Detection Open
In this paper, we propose MOUFLON, a fairness-aware, modularity-based community detection method that allows adjusting the importance of partition quality over fairness outcomes. MOUFLON uses a novel proportional balance fairness metric, p…
View article: Global pharmacovigilance reporting of the first monoclonal antibody for canine osteoarthritis: a case study with bedinvetmab (Librela™)
Global pharmacovigilance reporting of the first monoclonal antibody for canine osteoarthritis: a case study with bedinvetmab (Librela™) Open
Introduction Continuous product monitoring post approval builds on the knowledge gained during clinical studies to aid in understanding a product’s safety and efficacy profile. Pharmacovigilance reporting of a medicinal product might be in…
View article: Digital Valuation: Lessons in relevance from the prototyping of a recommendation app
Digital Valuation: Lessons in relevance from the prototyping of a recommendation app Open
This article describes the use of a prototype recommendation app to explore how users are included and/or excluded in categories of various kinds of ‘People Like You’. In the study, interviews with users of the prototype app indicate that …
View article: EUMETNET Nowcasting Programme
EUMETNET Nowcasting Programme Open
One major task of the National Meteorological and Hydrological Services (NMHS) is the provision of consistent and integrated forecasting products from minutes to several days ahead (seamless forecasting). The former EUMETNET (European Mete…
View article: Anticoagulation in syncardia total artificial heart recipients: anti-factor Xa or activated partial thromboplastin time?
Anticoagulation in syncardia total artificial heart recipients: anti-factor Xa or activated partial thromboplastin time? Open
Although the activated partial thromboplastin time (aPTT) has historically been the method of choice for anticoagulation monitoring in patients undergoing mechanical circulatory support with intravenous unfractionated heparin, it is being …
View article: Utilization of extracorporeal membrane oxygenation in DCD and DBD lung transplants: a 2‐year single‐center experience
Utilization of extracorporeal membrane oxygenation in DCD and DBD lung transplants: a 2‐year single‐center experience Open
Donation after circulatory death (DCD) has the potential to expand the lung donor pool. We aimed to assess whether DCD affected the need for perioperative extracorporeal membrane oxygenation (ECMO) and perioperative outcomes in lung transp…
View article: Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device – the SERCA-LVAD TRIAL
Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device – the SERCA-LVAD TRIAL Open
The SERCA-LVAD trial was a phase 2a trial assessing the safety and feasibility of delivering an adeno-associated vector 1 carrying the cardiac isoform of the sarcoplasmic reticulum calcium ATPase (AAV1/SERCA2a) to adult chronic heart failu…
View article: Subclavian Impella 5.0 to the rescue in a non-ST elevation myocardial infarction patient requiring unprotected left main rotablation: A case report
Subclavian Impella 5.0 to the rescue in a non-ST elevation myocardial infarction patient requiring unprotected left main rotablation: A case report Open
This case highlights the need for cross-specialty collaborations in such high-risk cases were alternative access is needed for insertion of large bore mechanical circulatory support devices.
View article: Surgical explant of a right ventricular assist device with sternum-sparing technique
Surgical explant of a right ventricular assist device with sternum-sparing technique Open
The use of long-term mechanical assist devices for isolated right ventricular failure is rare. Herein, we describe our protocol for successful recovery of the right ventricle and subsequent explantation of a right ventricular assist device…
View article: Spontaneous subdural haematoma in a patient with a total artificial heart on warfarin
Spontaneous subdural haematoma in a patient with a total artificial heart on warfarin Open
We present the unusual case of a middle-aged woman who developed a spontaneous subdural haematoma (SSH) while on oral anticoagulation therapy for a total artificial heart (TAH). Headache was followed by paraesthesia and numbness of the lef…
View article: Left ventricular assist devices exchange: why, when and how to do it—experience from experts
Left ventricular assist devices exchange: why, when and how to do it—experience from experts Open
Left ventricular assist devices (LVAD) became a routine instrument in the treatment of severe heart failure with constantly increasing number of patients treated with LVAD (1). Continuous technical development and large empirical knowledge…
View article: The role of extracorporeal life support in the management with severe idiopathic pulmonary artery hypertension undergoing lung transplantation: are those patients referred too late?
The role of extracorporeal life support in the management with severe idiopathic pulmonary artery hypertension undergoing lung transplantation: are those patients referred too late? Open
ECLS is an essential tool in the armamentarium of any lung transplant program treating iPAH with a potential of bridge patients to transplantation and to overcome graft dysfunction after LTx. Despite utilization of ECLS in the management o…
View article: Comparison of temporary ventricular assist devices and extracorporeal life support in post-cardiotomy cardiogenic shock
Comparison of temporary ventricular assist devices and extracorporeal life support in post-cardiotomy cardiogenic shock Open
VAD and ECMO represent essential tools to support patients with PCCS. Our preliminary results might indicate some benefits of using VAD in this group of patients; however, this evidence should be further assessed in larger multicentre tria…
View article: Right atrial and ventricular echocardiographic strain analysis predicts requirement for right ventricular support after left ventricular assist device implantation
Right atrial and ventricular echocardiographic strain analysis predicts requirement for right ventricular support after left ventricular assist device implantation Open
The need for right ventricular assist device (RVAD) support after left ventricular assist device (LVAD) therapy is associated with increased morbidity and mortality. We used 2D echocardiographic strain analysis to assess right atrial (RA) …
View article: Mid-to-long term mortality following surgical versus percutaneous coronary revascularization stratified according to stent subtype: An analysis of 6,682 patients with multivessel disease
Mid-to-long term mortality following surgical versus percutaneous coronary revascularization stratified according to stent subtype: An analysis of 6,682 patients with multivessel disease Open
In this real-world analysis, when adjusting for measured and unmeasured confounding, PCI with SDES had comparable 5-year mortality when compared to CABG. This warrants evaluation in adequately-powered randomized controlled trials.
View article: Current approaches in retrieval and heart preservation
Current approaches in retrieval and heart preservation Open
Fifty years after the first successful heart transplantation, despite multiple advances in the treatment of advanced acute and chronic heart failure, there is still no equivalent to heart transplantation as a long-term treatment for end-st…
View article: Algorithms to guide ambulance clinicians in the management of emergencies in patients with implanted rotary left ventricular assist devices
Algorithms to guide ambulance clinicians in the management of emergencies in patients with implanted rotary left ventricular assist devices Open
Advances in left ventricular assist device (LVAD) therapy have resulted in increasing numbers of adult LVAD recipients in the community. However, device failure, stroke, bleeding, LVAD thrombosis and systemic infection can be life-threaten…
View article: Competing Flow Between Partial Circulatory Support and Native Cardiac Output: A Clinical Computational Fluid Dynamics Study
Competing Flow Between Partial Circulatory Support and Native Cardiac Output: A Clinical Computational Fluid Dynamics Study Open
Partial circulatory support is a promising concept for the treatment of heart failure patients. A better understanding of induced hemodynamic changes is essential for optimizing treatment efficacy. Computational fluid dynamics (CFD) is an …
View article: An Overview of Smart Shoes in the Internet of Health Things: Gait and Mobility Assessment in Health Promotion and Disease Monitoring
An Overview of Smart Shoes in the Internet of Health Things: Gait and Mobility Assessment in Health Promotion and Disease Monitoring Open
New smart technologies and the internet of things increasingly play a key role in healthcare and wellness, contributing to the development of novel healthcare concepts. These technologies enable a comprehensive view of an individual’s move…
View article: An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK
An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK Open
Background Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use. Objective The objecti…
View article: Zonal organ allocation system and its impact on long-term outcomes after lung transplantation: a propensity score matched analysis<sup>†</sup>
Zonal organ allocation system and its impact on long-term outcomes after lung transplantation: a propensity score matched analysis<sup>†</sup> Open
Despite excellent early outcomes the zonal allocation system might be associated with significantly poorer long-term outcomes in terms of freedom from BOS after bilateral LTx. Further research is needed to find the underlying factors leadi…
View article: Long-term support of patients receiving a left ventricular assist device for advanced heart failure: a follow-up analysis of the Registry to Evaluate the HeartWare Left Ventricular Assist System
Long-term support of patients receiving a left ventricular assist device for advanced heart failure: a follow-up analysis of the Registry to Evaluate the HeartWare Left Ventricular Assist System Open
Owing to the low rate of heart transplants, a significant number of patients receiving a left ventricular assist device as a bridge to transplant remain on support for prolonged periods, often exceeding 2, 3 and even 4 years. Real-world us…