S. Barak Caine
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View article: Sprague Dawley rats from different vendors vary in the modulation of prepulse inhibition of startle (PPI) by dopamine, acetylcholine, and glutamate drugs
Sprague Dawley rats from different vendors vary in the modulation of prepulse inhibition of startle (PPI) by dopamine, acetylcholine, and glutamate drugs Open
Rationale Rodent vendors are often utilized interchangeably, assuming that the phenotype of a given strain remains standardized between colonies. Several studies, however, have found significant behavioral and physiological differences bet…
View article: CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors
CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors Open
CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntington’s di…
View article: Differential Effects of Nicotine and Nicotine Withdrawal on Fear Conditioning in Male Rats
Differential Effects of Nicotine and Nicotine Withdrawal on Fear Conditioning in Male Rats Open
Background Tobacco use is prevalent in individuals who are routinely exposed to stress. However, little is known about how nicotine affects responses to trauma. We examined in rats how nicotine exposure affects fear conditioning, a procedu…
View article: Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human
Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human Open
SUMMARY Syndromes caused by mutations in Ras-MAP kinase signaling molecules are known as RASopathies and share features such as developmental delay, autistic traits, and cancer. Syndromic features of Rap-MAP kinase signaling defects remain…
View article: Effects of the <scp>GLP</scp>‐1 Agonist Exendin‐4 on Intravenous Ethanol Self‐Administration in Mice
Effects of the <span>GLP</span>‐1 Agonist Exendin‐4 on Intravenous Ethanol Self‐Administration in Mice Open
Background Glucagon‐like peptide 1 ( GLP ‐1) receptor agonists have been shown to decrease ethanol (EtOH) drinking in rodent assays. The GLP ‐1 system also powerfully modulates food and fluid intake, gastrointestinal functions, and metabol…