Simon Bernèche
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View article: Calcium regulates acid-sensing ion channel 3 activation by competing with protons in the channel pore and at an allosteric binding site
Calcium regulates acid-sensing ion channel 3 activation by competing with protons in the channel pore and at an allosteric binding site Open
The extracellular Ca 2+ concentration changes locally under certain physiological and pathological conditions. Such variations affect the function of ion channels of the nervous system and consequently also neuronal signalling. We investig…
View article: Source data from Calcium regulates acid-sensing ion channel 3 activation by competing with protons in the channel pore and at an allosteric binding site
Source data from Calcium regulates acid-sensing ion channel 3 activation by competing with protons in the channel pore and at an allosteric binding site Open
Contains source data on which the figures are based
View article: The Voltage-Dependent Deactivation of the KvAP Channel Involves the Breakage of Its S4 Helix
The Voltage-Dependent Deactivation of the KvAP Channel Involves the Breakage of Its S4 Helix Open
Voltage-gated potassium channels (Kv) allow ion permeation upon changes of the membrane electrostatic potential (Vm). Each subunit of these tetrameric channels is composed of six transmembrane helices, of which the anti-parallel helix bund…
View article: Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels
Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels Open
The CLC family comprises H+-coupled exchangers and Cl- channels, and mutations causing their dysfunction lead to genetic disorders. The CLC exchangers, unlike canonical 'ping-pong' antiporters, simultaneously bind and translocate substrate…
View article: Author response: Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels
Author response: Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The CLC family comprises H+-coupled exchan…
View article: Molecular dynamics free energy calculations highlighting the role of F357 in the function of the CLC-ec1 Cl-/H+ antiporter
Molecular dynamics free energy calculations highlighting the role of F357 in the function of the CLC-ec1 Cl-/H+ antiporter Open
Figure 2:•Molecular system snapshots extracted from the PMFs of Figures 2C (X1=-70º) and 2D (X1=-160º), in PDB format.Figure 3:•Molecular system snapshots extracted from the PMFs of Figure 2A and Figure 3 - Figure supplement 1, in PDB form…
View article: Molecular dynamics free energy calculations highlighting the role of F357 in the function of the CLC-ec1 Cl-/H+ antiporter
Molecular dynamics free energy calculations highlighting the role of F357 in the function of the CLC-ec1 Cl-/H+ antiporter Open
Figure 2:•2D PMF calculations describing the permeation of two Cl- ions in the pore of the CLC-ec1 Cl-/H+ antiporter, with F357 side chain restrained to either of two rotamers, or without any restraint.•1D PMF calculations describing the s…
View article: The voltage-sensing mechanism of the KvAP channel involves breaking of the S4 helix
The voltage-sensing mechanism of the KvAP channel involves breaking of the S4 helix Open
Voltage-gated ion channels allow ion permeation upon changes of the membrane electrostatic potential (Vm). Each subunit of these tetrameric channels is composed of six transmembrane helices, of which the anti-parallel helix bundle S1-S4 co…
View article: Divergent Cl<sup>−</sup> and H<sup>+</sup> pathways underlie transport coupling and gating in CLC exchangers and channels
Divergent Cl<sup>−</sup> and H<sup>+</sup> pathways underlie transport coupling and gating in CLC exchangers and channels Open
The CLC family of anion transporting proteins is comprised of secondary active H + -coupled exchangers and of Cl − channels. Both functional subtypes play key roles in human physiology, and mutations causing their dysfunction lead to numer…
View article: Mechanism of activation at the selectivity filter of the KcsA K+ channel
Mechanism of activation at the selectivity filter of the KcsA K+ channel Open
Potassium channels are opened by ligands and/or membrane potential. In voltage-gated K+ channels and the prokaryotic KcsA channel, conduction is believed to result from opening of an intracellular constriction that prevents ion entry into …
View article: Author response: Mechanism of activation at the selectivity filter of the KcsA K+ channel
Author response: Mechanism of activation at the selectivity filter of the KcsA K+ channel Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Potassium channels are opened by ligands and/or…
View article: Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating
Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating Open
Significance Many physiological processes are regulated by pH. The acid-sensing ion channels (ASICs) are neuronal pH sensors involved in learning, fear behavior, neurodegeneration after ischemic stroke, and pain sensation. The mechanism by…
View article: Unidirectional Transport Mechanism in an ATP Dependent Exporter
Unidirectional Transport Mechanism in an ATP Dependent Exporter Open
ATP-binding cassette (ABC) transporters use the energy of ATP binding and hydrolysis to move a large variety of compounds across biological membranes. P-glycoprotein, involved in multidrug resistance, is the most investigated eukaryotic fa…
View article: Molecular Mechanism of Cl − /H + Coupling in a CLC Antiporter
Molecular Mechanism of Cl − /H + Coupling in a CLC Antiporter Open
View article: Effect of Membrane Composition on Ion Conduction in a Voltage-Gated Potassium Channel
Effect of Membrane Composition on Ion Conduction in a Voltage-Gated Potassium Channel Open
View article: Catch-bond mechanism of the bacterial adhesin FimH
Catch-bond mechanism of the bacterial adhesin FimH Open
View article: Mechanism of NH 4 + Recruitment and NH 3 Transport in Rh Proteins
Mechanism of NH 4 + Recruitment and NH 3 Transport in Rh Proteins Open
View article: Backbone Hydration Determines the Folding Signature of Amino Acid Residues
Backbone Hydration Determines the Folding Signature of Amino Acid Residues Open
The relation between the sequence of a protein and its three-dimensional structure remains largely unknown. A lasting dream is to elucidate the side-chain-dependent driving forces that govern the folding process. Different structural data …