Simon Bissonnette
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View article: EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors
EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors Open
Elevated numbers of atherogenic lipoproteins (apoB) predict the incidence of type 2 diabetes (T2D). We reported that this may be mediated via the activation of the NLRP3 inflammasome, as low-density lipoproteins (LDL) induce interleukin-1 …
View article: EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors
EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors Open
Elevated numbers of atherogenic lipoproteins (apoB), mostly circulating as low-density lipoproteins (LDL), predict diabetes risk. We recently reported that native LDL upregulate the NLRP3 inflammasome/interleukin-1β (IL-1β) pathway in huma…
View article: Native low-density lipoproteins are priming signals of the NLRP3 inflammasome/interleukin-1β pathway in human adipose tissue and macrophages
Native low-density lipoproteins are priming signals of the NLRP3 inflammasome/interleukin-1β pathway in human adipose tissue and macrophages Open
Elevated plasma numbers of atherogenic apoB-lipoproteins (apoB), mostly as low-density lipoproteins (LDL), predict diabetes risk by unclear mechanisms. Upregulation of the NLRP3 inflammasome/interleukin-1 beta (IL-1β) system in white adipo…
View article: Native low-density lipoproteins are priming signals of adipose tissue NLRP3 inflammasome/ interleukin-1β pathway in humans
Native low-density lipoproteins are priming signals of adipose tissue NLRP3 inflammasome/ interleukin-1β pathway in humans Open
Elevated numbers of atherogenic apoB-lipoproteins (apoB), mostly as low-density lipoproteins (LDL) predict diabetes risk by unclear mechanisms. Upregulation of the innate immunity pathway, the NLRP3 inflammasome/interleukin-1 beta (IL-1β) …
View article: Sex-Specific Models to Predict Insulin Secretion and Sensitivity in Subjects with Overweight and Obesity
Sex-Specific Models to Predict Insulin Secretion and Sensitivity in Subjects with Overweight and Obesity Open
Sex-specific differences exist in insulin secretion (ISec) and sensitivity (IS) in humans. However, current fasting indices used to estimate them, such as HOMA and QUICKI, are not sex-specific. We aimed to develop sex-specific models to im…
View article: Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface‐expression of LDLR and CD36 and NLRP3 inflammasome
Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface‐expression of LDLR and CD36 and NLRP3 inflammasome Open
Normocholesterolemic subjects with lower plasma PCSK9 and higher WAT surface-expression of LDLR and CD36 have higher WAT NLRP3 inflammasome activation and T2D risk factors. This may be due to LDL-induced inhibition of adipocyte function.
View article: The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults
The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults Open
View article: Les apoB-lipoprotéines en tant que modulateurs de la fonction du tissu adipeux et des facteurs de risque du diabète de type 2 chez l'humain
Les apoB-lipoprotéines en tant que modulateurs de la fonction du tissu adipeux et des facteurs de risque du diabète de type 2 chez l'humain Open
Le diabète de type 2 (DT2) est une maladie chronique affectant 3 millions de canadiens. Une augmentation progressive de la résistance à l'insuline (RI) et de la sécrétion d'insuline est observée chez des sujets normoglycémiques bien avant …
View article: High plasma apolipoprotein B identifies obese subjects who best ameliorate white adipose tissue dysfunction and glucose-induced hyperinsulinemia after a hypocaloric diet
High plasma apolipoprotein B identifies obese subjects who best ameliorate white adipose tissue dysfunction and glucose-induced hyperinsulinemia after a hypocaloric diet Open
View article: WAT apoC-I secretion: role in delayed chylomicron clearance in vivo and ex vivo in WAT in obese subjects
WAT apoC-I secretion: role in delayed chylomicron clearance in vivo and ex vivo in WAT in obese subjects Open
Reduced white adipose tissue (WAT) LPL activity delays plasma clearance of TG-rich lipoproteins (TRLs). We reported the secretion of apoC-I, an LPL inhibitor, from WAT ex vivo in women. Therefore we hypothesized that WAT-secreted apoC-I as…
View article: Plasma IL-1Ra: linking hyperapoB to risk factors for type 2 diabetes independent of obesity in humans
Plasma IL-1Ra: linking hyperapoB to risk factors for type 2 diabetes independent of obesity in humans Open
Background/Objective: Plasma apoB predicts the incidence of type 2 diabetes (T2D); however, the link between apoB-linpoproteins and risks for T2D remain unclear. Insulin resistance (IR) and compensatory hyperinsulinemia characterize predia…