Simon Hansen
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View article: Molecular features defining the efficiency of bioPROTACs
Molecular features defining the efficiency of bioPROTACs Open
BioPROTACs consist of a target-binding unit and a component of the ubiquitin-proteasome system. However, the specific biophysical features influencing their effectiveness are poorly understood. We investigated the design principles definin…
A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling Open
The Vps10p-domain receptors SorCS1-3 have been repeatedly associated with the development of neurological and psychiatric disorders. They have emerged as key regulators of synaptic activity and neurotrophic signaling, but the underlying mo…
Structure of the Wnt–Frizzled–LRP6 initiation complex reveals the basis for coreceptor discrimination Open
Wnt morphogens are critical for embryonic development and tissue regeneration. Canonical Wnts form ternary receptor complexes composed of tissue-specific Frizzled (Fzd) receptors together with the shared LRP5/6 coreceptors to initiate β-ca…
Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling Open
Developing peptide-based tools to fine-tune growth signaling pathways, in particular molecules with exquisite selectivity and high affinities, opens up opportunities for cellular reprogramming in tissue regeneration. Here, we present a lib…
Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for co-receptor discrimination Open
Wnt morphogens are critical for embryonic development and tissue regeneration. Canonical Wnts form ternary receptor complexes composed of tissue-specific Frizzled receptors together with the shared LRP5/6 co-receptors to initiate β-catenin…
The Influence of Musculoskeletal Pain On Exercise-Induced Hypoalgesia in Humans: an Experimental and Clinical Exploratory Approach Open
1998 from University of Copenhagen, where after he worked 1½ year as a scholarship student at University of Copenhagen within human neurophysiological movement research.This research, resulting in a number of international peer-reviewed ar…
Lead Optimization Yields High Affinity Frizzled 7-Targeting Peptides That Modulate <i>Clostridium difficile</i> Toxin B Pathogenicity in Epithelial Cells Open
Frizzled 7 (FZD7) receptors have been shown to play a central role in intestinal stem cell regeneration and, more recently, in Clostridium difficile pathogenesis. Yet, targeting FZD7 receptors with small ligands has not been explored as an…
Structures of designed armadillo repeat proteins binding to peptides fused to globular domains Open
Designed armadillo repeat proteins (dArmRP) are α‐helical solenoid repeat proteins with an extended peptide binding groove that were engineered to develop a generic modular technology for peptide recognition. In this context, the term “pep…