Simon Bossi
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View article: Excitatory glycine receptors control ventral hippocampus synaptic plasticity and anxiety-related behaviors
Excitatory glycine receptors control ventral hippocampus synaptic plasticity and anxiety-related behaviors Open
Excitatory glycine receptors (eGlyRs), composed of the glycine-binding NMDA receptor subunits GluN1 and GluN3A, have recently emerged as a novel neuronal signaling modality that challenges the traditional view of glycine as an inhibitory n…
View article: Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes
Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes Open
Astrocytes are increasingly appreciated to possess underestimated and important roles in modulating neuronal circuits. Astrocytes in striatum can regulate dopamine transmission by governing the extracellular tone of axonal neuromodulators,…
View article: Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex
Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex Open
The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by a variety of presynaptic receptors, notably by type 4 metabotropic glutamate (mGlu4) receptors and type 1 …
View article: Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes
Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes Open
SUMMARY Astrocytes are increasingly thought to have underestimated and important roles in modulating neuronal circuits. Astrocytes in striatum can regulate dopamine transmission by governing the extracellular tone of axonal neuromodulators…
View article: Intracranial injections of viral vectors in mouse striatum v1
Intracranial injections of viral vectors in mouse striatum v1 Open
The following protocol outlines the steps necessary for intracranial injections of viral vectors in dorsal or ventral striatum in mice. These steps are generalisable for different viruses and injection sites, however care must be taken to …
View article: A Light-Controlled Allosteric Modulator Unveils a Role for mGlu4 Receptors During Early Stages of Ischemia in the Rodent Cerebellar Cortex
A Light-Controlled Allosteric Modulator Unveils a Role for mGlu4 Receptors During Early Stages of Ischemia in the Rodent Cerebellar Cortex Open
Metabotropic glutamate receptors (mGlus) are G Protein coupled-receptors that modulate synaptic transmission and plasticity in the central nervous system. Some act as autoreceptors to control neurotransmitter release at excitatory synapses…