Simon Braumann
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View article: Myeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity
Myeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity Open
Obesity, a main driver of cardiovascular morbidity, contributes to endothelial dysfunction and inflammation in adipose tissues. Perivascular adipose tissue (PVAT) surrounds arteries and influences vascular function. In obesity, immune cell…
View article: MYSTERY-HF: Myeloperoxidase Inhibition in Patients With Heart Failure and Reduced Ejection Fraction: A Phase II Randomized Controlled Trial
MYSTERY-HF: Myeloperoxidase Inhibition in Patients With Heart Failure and Reduced Ejection Fraction: A Phase II Randomized Controlled Trial Open
View article: Inhibition of myeloperoxidase to treat left ventricular dysfunction in non‐ischaemic cardiomyopathy
Inhibition of myeloperoxidase to treat left ventricular dysfunction in non‐ischaemic cardiomyopathy Open
Aims Non‐ischaemic cardiomyopathy (NICMP), an incurable disease terminating in systolic heart failure (heart failure with reduced ejection fraction [HFrEF]), causes immune activation, however anti‐inflammatory treatment strategies so far h…
View article: Exercise related versus non exercise related out of hospital cardiac arrest – A retrospective single-center study
Exercise related versus non exercise related out of hospital cardiac arrest – A retrospective single-center study Open
Based on this observational data from a highly selected group of out-of-hospital cardiac arrest patients treated at a cardiac arrest center, patients suffering an exercise related out-of-hospital cardiac arrest, differed in substantial cha…
View article: Right ventricular dysfunction and impaired right ventricular–pulmonary arterial coupling in paradoxical low‐flow, low‐gradient aortic stenosis
Right ventricular dysfunction and impaired right ventricular–pulmonary arterial coupling in paradoxical low‐flow, low‐gradient aortic stenosis Open
Aims Paradoxical low‐flow, low‐gradient aortic stenosis (pLFLG AS) may represent a diagnostic challenge, and its pathophysiology is complex. While left ventricular (LV) systolic function is preserved, right ventricular dysfunction (RVD) an…
View article: Exercise Related Versus Non Exercise Related Out of Hospital Cardiac Arrest – a Retrospective Single-Center Study
Exercise Related Versus Non Exercise Related Out of Hospital Cardiac Arrest – a Retrospective Single-Center Study Open
View article: Präklinisches Loading bei Patienten mit akutem Thoraxschmerz und akutem Koronarsyndrom – PRELOAD-Umfrage
Präklinisches Loading bei Patienten mit akutem Thoraxschmerz und akutem Koronarsyndrom – PRELOAD-Umfrage Open
Zusammenfassung Hintergrund Leitlinien zum Myokardinfarkt (MI) empfehlen eine blutverdünnende Therapie zum Diagnosezeitpunkt. Während der MI mit ST-Streckenhebung (STEMI) präklinisch sicher detektiert werden kann, ist das akute Koronarsynd…
View article: Restrictive versus high-dose oxygenation strategy in post-arrest management following adult non-traumatic cardiac arrest: a meta-analysis
Restrictive versus high-dose oxygenation strategy in post-arrest management following adult non-traumatic cardiac arrest: a meta-analysis Open
View article: Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy
Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy Open
Cardiotoxicity is a major complication of anthracycline therapy that negatively impacts prognosis. Effective pharmacotherapies for prevention of anthracycline-induced cardiomyopathy (AICM) are currently lacking. Increased plasma levels of …
View article: Optical coherence tomography-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndrome: a meta-analysis
Optical coherence tomography-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndrome: a meta-analysis Open
View article: Outcome of Out-of-Hospital Cardiac Arrest Patients Stratified by Pre-Clinical Loading with Aspirin and Heparin: A Retrospective Cohort Analysis
Outcome of Out-of-Hospital Cardiac Arrest Patients Stratified by Pre-Clinical Loading with Aspirin and Heparin: A Retrospective Cohort Analysis Open
Background: Out-of-hospital cardiac arrest (OHCA) has a high prevalence of obstructive coronary artery disease and total coronary occlusion. Consequently, these patients are frequently loaded with antiplatelets and anticoagulants before ho…
View article: Acute chest pain—diagnostic accuracy and pre-hospital use of anticoagulants and platelet aggregation inhibitors
Acute chest pain—diagnostic accuracy and pre-hospital use of anticoagulants and platelet aggregation inhibitors Open
ASA and UFH are often given to EP-accompanied patients with aCP despite the low accuracy of diagnosis in the pre-hospital setting. Pre-hospital measurement of high-sensitivity troponin T (hs Trop-T) might improve discrimination between NST…
View article: Meta-analysis of extracorporeal membrane oxygenation in combination with intra-aortic balloon pump vs. extracorporeal membrane oxygenation only in patients with cardiogenic shock due to acute myocardial infarction
Meta-analysis of extracorporeal membrane oxygenation in combination with intra-aortic balloon pump vs. extracorporeal membrane oxygenation only in patients with cardiogenic shock due to acute myocardial infarction Open
Background Incidence and mortality of cardiogenic shock (CS) in patients with acute myocardial infarction (AMI) remain high despite substantial therapy improvements in acute percutaneous coronary intervention over the last decades. Unloadi…
View article: Protective Effects of Therapeutic Neutrophil Depletion and Myeloperoxidase Inhibition on Left Ventricular Function and Remodeling in Myocardial Infarction
Protective Effects of Therapeutic Neutrophil Depletion and Myeloperoxidase Inhibition on Left Ventricular Function and Remodeling in Myocardial Infarction Open
Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. Improved survival has led to an increasing incidence of ischemic cardiomyopathy, making it a major reason for hospitalization in the western world. The inf…
View article: Myeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy
Myeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy Open
Cardiotoxicity is a major complication of anthracycline therapy that negatively impacts prognosis. Effective pharmacotherapies for prevention of anthracycline-induced cardiomyopathy (AICM) are currently lacking. Increased plasma levels of …
View article: Inhibition of myeloperoxidase attenuates thoracic aortic aneurysm formation in Marfan disease
Inhibition of myeloperoxidase attenuates thoracic aortic aneurysm formation in Marfan disease Open
Marfan syndrome (MFS) is the most prevalent inherited connective tissue disorder, still remains uncurable, and is characterized by high mortality at early age driven by dissection and rupture of thoracic aortic aneurysms. MFS is caused by …
View article: Treatment of left ventricular dysfunction in dilated cardiomyopathy with a myeloperoxidase inhibitor
Treatment of left ventricular dysfunction in dilated cardiomyopathy with a myeloperoxidase inhibitor Open
Dilated cardiomyopathy (DCM), an incurable disease of the cardiomyocyte terminating in systolic heart failure (HFrEF), is prevalent, causes hospitalization and is associated with increased mortality. Despite evidence of immune activation i…
View article: Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production
Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production Open
Sniffing out atherosclerosis Olfactory receptors are best known for their presence in the nose and their role in detecting smells, but they are also present in other tissues and perform additional biological functions. For example, vascula…
View article: Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B
Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B Open
Atherosclerosis is a chronic, lipid-driven disease of medium sized arteries which causes myocardial infarction and stroke. Recently, an adaptive immune response against the plaque-associated autoantigen Apolipoprotein B100 (ApoB), the stru…
View article: Impact of respiratory infectious epidemics on STEMI incidence and care
Impact of respiratory infectious epidemics on STEMI incidence and care Open
The effect of respiratory infectious diseases on STEMI incidence, but also STEMI care is not well understood. The Influenza 2017/2018 epidemic and the COVID-19 pandemic were chosen as observational periods to investigate the effect of resp…
View article: Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation
Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation Open
The six-transmembrane protein of prostate 2 (Stamp2) acts as an anti-inflammatory protein in macrophages by protecting from overt inflammatory signaling and Stamp2 deficiency accelerates atherosclerosis in mice. Herein, we describe an unex…
View article: Nitro-Oleic Acid (NO2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis
Nitro-Oleic Acid (NO2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis Open
Nitro-oleic acid (NO2-OA), a nitric oxide (NO)- and nitrite (NO2−)-derived electrophilic fatty acid metabolite, displays anti-inflammatory and anti-fibrotic signaling actions and therapeutic benefit in murine models of ischemia-reperfusion…
View article: Absolute serum neurofilament light chain levels and its early kinetics predict brain injury after out-of-hospital cardiac arrest
Absolute serum neurofilament light chain levels and its early kinetics predict brain injury after out-of-hospital cardiac arrest Open
Objectives To test if the early kinetics of neurofilament light (NFL) in blood adds to the absolute values of NFL in the prediction of outcome, and to evaluate if NFL can discriminate individuals with severe hypoxic–ischemic brain injury (…
View article: Is there a benefit of ICD treatment in patients with persistent severely reduced systolic left ventricular function after TAVI?
Is there a benefit of ICD treatment in patients with persistent severely reduced systolic left ventricular function after TAVI? Open
View article: Gender‐related differences in treatment and outcome of extracorporeal cardiopulmonary resuscitation‐patients
Gender‐related differences in treatment and outcome of extracorporeal cardiopulmonary resuscitation‐patients Open
Extracorporeal cardiopulmonary resuscitation (eCPR) is a rapidly growing treatment strategy due to significant improvement in selected patients' survival rates. Gender‐related differences might impact the outcome of therapeutic measures. T…
View article: Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis
Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis Open
View article: Molecular mechanisms underlying cardiotoxicity of novel cancer therapeutics
Molecular mechanisms underlying cardiotoxicity of novel cancer therapeutics Open
Novel cancer therapeutics contribute to a steadily declining cancer mortality. However, several of these new therapies target pathways also involved in the cardiovascular system thus causing cardiotoxic side effects such as chemotherapy-in…
View article: S100A4 as a Target of the E3-Ligase Asb2β and Its Effect on Engineered Heart Tissue
S100A4 as a Target of the E3-Ligase Asb2β and Its Effect on Engineered Heart Tissue Open
Background: S100A4 has recently emerged as an important player in cardiac disease, affecting phenotype development in animal models of myocardial infarction and pathological cardiac hypertrophy, albeit it is unclear whether S100A4 e…