Explanipedia

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis Open

Simon C Langton Hewer, Sherie Smith, Nicola J. Rowbotham, Alexander Yule, Alan R Smyth · 2023

We found that nebulised antibiotics, alone or with oral antibiotics, were better than no treatment for early infection with P aeruginosa. Eradication may be sustained in the short term. There is insufficient evidence to determine whether t…

Dietary interventions for managing glucose abnormalities in people with cystic fibrosis Open

Laura Birch, Rachel Perry, Julian Hamilton‐Shield, Julian P. T. Higgins, Fiona E. Lithander , et al. · 2022

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of dietary interventions on glycaemic control and clinical status in people with cystic fibrosis who have dysglycaemia.

Intravenous or oral antibiotic treatment in adults and children with cystic fibrosis and Pseudomonas aeruginosa infection: the TORPEDO-CF RCT Open

Simon C Langton Hewer, Alan R Smyth, Michaela Brown, Ashley P Jones, Helen Hickey , et al. · 2021

Background People with cystic fibrosis are susceptible to pulmonary infection with Pseudomonas aeruginosa . This may become chronic and lead to increased mortality and morbidity. If treatment is commenced promptly, infection may be eradica…

Children’s charter for lung health Open

Nicholas S Hopkinson, Warren Lenney, Simon C Langton Hewer, Jonathan Bennett, Ema Swingwood , et al. · 2021

Every child and young person has the right to breathe clean air, with healthy lungs. Pre-conception, in utero and early life conditions affect children’s lungs, their lung growth and their long-term health. Government, societal and individ…

A breathless teenager Open

Cara N. Cochrane, Neil Collin, Simon C Langton Hewer · 2021

In children with persistent chylothoraces of unknown origin, intranodal lymphangiography can be used to help identify the source of a leak. This may enable embolisation with glue and coils to enable resolution of the chylothoraces. …

Intravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial Open

Simon C Langton Hewer, Alan R Smyth, Michaela Brown, Ashley P Jones, Helen Hickey , et al. · 2020

National Institute for Health Research Health Technology Assessment Programme.

The ERS approach to e-cigarettes is entirely rational Open

Andrew Bush, Jayesh Bhatt, Will Carroll, Frances Child, Gary Connett , et al. · 2020

“This is an author-submitted, peer-reviewed version of a manuscript that has been accepted for publication in the European Respiratory Journal, prior to copy-editing, formatting and typesetting. This version of the manuscript may not be du…

Technique, pitfalls, quality, radiation dose and findings of dynamic 4-dimensional computed tomography for airway imaging in infants and children Open

Savvas Andronikou, Mark Chopra, Simon C Langton Hewer, Pia Maier, Jon Green , et al. · 2019

Referee report. For: Case Report: First report of Elizabethkingia miricola infection in a patient with cystic fibrosis [version 1; referees: 1 approved with reservations] Open

Simon C Langton Hewer · 2018

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis Open

Simon C Langton Hewer, Alan R Smyth · 2017

Respiratory tract infection with Pseudomonas aeruginosa occurs in most people with cystic fibrosis. Once chronic infection is established, Pseudomonas aeruginosa is virtually impossible to eradicate and is associated with increased mortali…

Pancreatic cystosis in cystic fibrosis Open

Helen E. Burt, Savvas Andronikou, Simon C Langton Hewer · 2016

A 17-year-old boy was diagnosed with cystic fibrosis at age 6 years.Genetic analysis revealed homozygous ΔF508 mutations.His first abdominal ultrasound was performed in March 2012 as part of the annual cystic fibrosis review.This demonstra…

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