Simon C. Watkins
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View article: Supplementary Data from Endometriosis-Associated Mesenchymal Stem Cells Support Ovarian Clear Cell Carcinoma through Iron Regulation
Supplementary Data from Endometriosis-Associated Mesenchymal Stem Cells Support Ovarian Clear Cell Carcinoma through Iron Regulation Open
Supplementary figures and table
View article: Vasa vasorum plexus formation in intracranial aneurysm associates with microcalcification and wall thickening
Vasa vasorum plexus formation in intracranial aneurysm associates with microcalcification and wall thickening Open
Intracranial aneurysms (IAs) affect about 3% of the population, often leading to catastrophic outcomes upon rupture. Vasa vasorum, microvessels supplying arterial walls, are conjectured to induce inflammation and leakage in IAs that drive …
View article: Genetic ancestry shapes dengue virus infection in human skin explants
Genetic ancestry shapes dengue virus infection in human skin explants Open
Dengue is the most prevalent arthropod-borne viral disease of humans, with over half the world’s population at risk. Infection with any of the four dengue virus (DENV) serotypes is most often self-limiting, but a significant number of case…
View article: Transplants foster B cell alloimmunity by relaying extracellular vesicles to follicular dendritic cells
Transplants foster B cell alloimmunity by relaying extracellular vesicles to follicular dendritic cells Open
B cells play fundamental roles in transplant rejection. However, how allogeneic (allo)-antigens (Ags) are transported from allografts to follicular dendritic cells (FDCs) in lymphoid tissues for development of B cell responses remains unkn…
View article: Elucidating the high compliance mechanism by which the urinary bladder fills under low pressures
Elucidating the high compliance mechanism by which the urinary bladder fills under low pressures Open
The high compliance of the urinary bladder during filling is essential for its proper function, enabling it to accommodate significant volumetric increases with minimal rise in transmural pressure. This study aimed to elucidate the physica…
View article: Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration
Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration Open
Human immunodeficiency virus type 1 (HIV-1) capsid, which is the target of the antiviral lenacapavir, protects the viral genome and binds multiple host proteins to influence intracellular trafficking, nuclear import, and integration. Previ…
View article: Long-range genomic loci stochastically assemble into combinatorial forms of chromosome skeleton
Long-range genomic loci stochastically assemble into combinatorial forms of chromosome skeleton Open
One fundamental yet open question is how eukaryotic chromosomes fold into segregated territories, a process essential for gene transcription and cell fate. Through analyzing Hi-C and chromatin-tracing DNA-FISH data, we identify long-range …
View article: Phosphorylated-tau associates with HSV-1 chromatin and correlates with nuclear speckles decondensation in low-density host chromatin regions
Phosphorylated-tau associates with HSV-1 chromatin and correlates with nuclear speckles decondensation in low-density host chromatin regions Open
Abnormal tau phosphorylation is a key mechanism in neurodegenerative diseases. Evidence implicates infectious agents, such as Herpes Simplex Virus 1 (HSV-1), as co-factors in the onset or the progression of neurodegenerative diseases, incl…
View article: Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration
Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration Open
Cardiac regeneration involves the interplay of complex interactions between many different cell types, including cardiomyocytes. The exact mechanism that enables cardiomyocytes to undergo dedifferentiation and proliferation to replace lost…
View article: Table S5 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Table S5 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
DEGs- cDC1 vs cDC2/MoDCs
View article: Figure S10 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S10 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 10 . CD91 expression on APC subsets in the skin and lymph nodes at steady state.
View article: Figure S16 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S16 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary figure 16. Single-cell analysis to compare APC subsets.
View article: Figure S8 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S8 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 8. Accumulation of tumor-derived gp96-EGFP in the draining lymph nodes.
View article: Figure S1 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S1 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 1. Dendritic cells in CD91 conditional knockouts under normal physiological conditions.
View article: Figure S9 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S9 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 9. Gating on lymph node resident and migratory antigen presenting cells under inflammatory conditions.
View article: Table S6 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Table S6 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
DEGs- cDC1 vs Macrophages
View article: Table S4 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Table S4 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
DEGs- cDC1 vs LCs
View article: Figure S5 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S5 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 5. Analysis of immune cell infiltrates in the skin after MCA injection.
View article: Figure S4 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S4 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 4. Evaluating gp96-EGFP accumulation in CCR7-deficient (Ccr7-/- ) and cDC1-specific CD91-deficient (CD91fl/flXCR1cre ) mice.
View article: Table S2 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Table S2 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
DEGs- cDC1 in CD91KO compared to WT.
View article: Table S1 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Table S1 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
List of antibodies used.
View article: Figure S11 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S11 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 11. Quantification of CD91 expression on APCs in the skin and draining lymph nodes.
View article: Figure S14 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S14 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 14. Antigen presenting cells within sorted and adoptively transferred cells. Lymph nodes from mice challenged with gp96-EGFP+ tumor were processed and sorted on live CD19- CD3- CD45+ CD11c+/- CD11b+/- gp96+ as shown in…
View article: Figure S13 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S13 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 13. Transfer of gp96-EGFP by CD11c+ CD11b- donors.
View article: Figure S3 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S3 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 3. Single-cell sequencing of CD11c+ APCs in the tumor-draining lymph nodes.
View article: Figure S7 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S7 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 7. Co-incubation of gp96-EGFP+ donors APCs with CD45.1+ recipient APCs.
View article: Figure S2 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S2 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary Figure 2. Validation of CD91 deletion in cDC1.
View article: Figure S15 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Figure S15 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
Supplementary figure 15. Separation of gp96-mediated anti-tumor immune function within APC subsets.
View article: Table S3 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Table S3 from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
DEGs- DP versus SP APCs
View article: Data from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors
Data from CD91 and Its Ligand gp96 Confer Cross-Priming Capabilities to Multiple APCs during Immune Responses to Nascent, Emerging Tumors Open
During cancer immunosurveillance, dendritic cells (DC) play a central role in orchestrating T-cell responses against emerging tumors. Capture of miniscule amounts of antigen along with tumor-initiated costimulatory signals can drive matura…