Simon Crawford
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View article: Hyperforin potentiates polymyxin B against multidrug-resistant Gram-negative pathogens via membrane disruption, biofilm eradication, and oxidative stress
Hyperforin potentiates polymyxin B against multidrug-resistant Gram-negative pathogens via membrane disruption, biofilm eradication, and oxidative stress Open
The escalating spread of multidrug-resistant (MDR) Gram-negative pathogens, particularly Pseudomonas aeruginosa , Klebsiella pneumoniae , and Acinetobacter baumannii , has severely undermined the efficacy of polymyxin B, one of the few rem…
View article: Actions of Taft Algebras on Noetherian Down-Up Algebras
Actions of Taft Algebras on Noetherian Down-Up Algebras Open
We consider actions of Taft algebras on noetherian graded down-up algebras. We classify all such actions and determine properties of the corresponding invariant rings $$A^T$$ . We identify precisely when $$A^T$$ is commutative, when it is …
View article: Size-stabilized, Hypoallometric, Genitalia Determined for Male Black Soldier Fly, <i>Hermetia illucens</i> (Diptera: Stratiomyidae)
Size-stabilized, Hypoallometric, Genitalia Determined for Male Black Soldier Fly, <i>Hermetia illucens</i> (Diptera: Stratiomyidae) Open
The black soldier fly, Hermetia illucens , is mass-reared throughout the world to convert organic waste into ingredients for pet and livestock feed, as well as frass and other biological products. To promote the optimization of breeding re…
View article: Bacterial species and surface structures shape gene transfer and the transcriptional landscape during active conjugation
Bacterial species and surface structures shape gene transfer and the transcriptional landscape during active conjugation Open
Conjugative plasmids drive bacterial evolution and niche adaptation, yet how their active acquisition reshapes host transcription remains poorly understood. Most studies focus on stable plasmid carriage, overlooking the dynamic transcripti…
View article: Corrosion Protection of Mild Steel in Acidic Environments by Cetrimonium Cinnamates in Solution and Added to a Low Volatile Organic Compound Coating
Corrosion Protection of Mild Steel in Acidic Environments by Cetrimonium Cinnamates in Solution and Added to a Low Volatile Organic Compound Coating Open
Protection of mild steel from acidic solutions used in the industry by environmentally friendly methods is an area of need. This work explores the anticorrosive properties of cetrimonium cinnamate compounds for mild steel in acid solutions…
View article: Asymmetric nanocapsules via elongated liposome templated polymerization (ELTP) mediated by RAFT polymerization
Asymmetric nanocapsules via elongated liposome templated polymerization (ELTP) mediated by RAFT polymerization Open
Polymeric nanocapsules comprised of hydrophobic shells and hollow aqueous interiors are an extremely useful class of nanomaterial, particularly in the encapsulation and controlled delivery of hydrophilic cargo. Generally prepared via dropl…
View article: Metabolic profiling unveils enhanced antibacterial synergy of polymyxin B and teixobactin against multi-drug resistant Acinetobacter baumannii
Metabolic profiling unveils enhanced antibacterial synergy of polymyxin B and teixobactin against multi-drug resistant Acinetobacter baumannii Open
This untargeted metabolomics study investigated the synergistic antibacterial activity of polymyxin B and Leu10-teixobactin, a depsipeptide inhibitor of cell wall biosynthesis. Checkerboard microdilution assays revealed a significant syner…
View article: Synergistic potential of Leu10-teixobactin and cefepime against multidrug-resistant Staphylococcus aureus
Synergistic potential of Leu10-teixobactin and cefepime against multidrug-resistant Staphylococcus aureus Open
Staphylococcus aureus ( S. aureus ) is a significant Gram-positive opportunistic pathogen behind many debilitating infections. β-lactam antibiotics are conventionally prescribed for treating S. aureus infections. However, the adaptability …
View article: Advancement in fruit drying through the analysis of moisture sorption isotherms: processing effects on Australian native fruits in comparison to apple
Advancement in fruit drying through the analysis of moisture sorption isotherms: processing effects on Australian native fruits in comparison to apple Open
Australian native fruits are well-adapted to local climate and have growing interest in their nutritional and sensory qualities. Among the most highly produced are finger limes and muntries. However, published literature on their character…
View article: Engineering Hyperechogenic Colloids with Clot-Targeting Capabilities from Platelet-Derived Membranes
Engineering Hyperechogenic Colloids with Clot-Targeting Capabilities from Platelet-Derived Membranes Open
Thrombosis-related cardiovascular diseases remain the leading global cause of mortality and morbidity. In this study, we present a pioneering approach in the field of nanobiotechnology, with a focus on clinical translation, aimed at advanc…
View article: Actions of Taft Algebras on Noetherian Down-Up Algebras
Actions of Taft Algebras on Noetherian Down-Up Algebras Open
We consider actions of Taft algebras on noetherian graded down-up algebras. We classify all such actions and determine properties of the corresponding invariant rings $A^T$. We identify precisely when $A^T$ is commutative, when it is Artin…
View article: Asymmetric Nanocapsules via Elongated Liposome Templated Polymerization (ELTP) Mediated by RAFT Polymerization
Asymmetric Nanocapsules via Elongated Liposome Templated Polymerization (ELTP) Mediated by RAFT Polymerization Open
Polymeric nanocapsules comprised of hydrophobic shells and hollow aqueous interiors are an extremely useful class of nanomaterial, particularly in the encapsulation and controlled delivery of hydrophilic cargo. Generally prepared via dropl…
View article: Heterogeny in cages: Age-structure and timing of attractant availability impacts fertile egg production in the black soldier fly,<i>Hermetia illucens</i>
Heterogeny in cages: Age-structure and timing of attractant availability impacts fertile egg production in the black soldier fly,<i>Hermetia illucens</i> Open
Adult behavior is a growing area of interest for those researching the black soldier fly, Hermetia illucens (L.) (Diptera: Stratiomyidae), which is affected by underlying demography and spatiotemporal patterns. This greenhouse experiment e…
View article: Cardiac-targeted delivery of a novel Drp1 inhibitor for acute cardioprotection
Cardiac-targeted delivery of a novel Drp1 inhibitor for acute cardioprotection Open
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View article: Mitochondrial abnormalities contribute to muscle weakness in a <i>Dnajb6</i> deficient zebrafish model
Mitochondrial abnormalities contribute to muscle weakness in a <i>Dnajb6</i> deficient zebrafish model Open
Mutations in DNAJB6 are a well-established cause of limb girdle muscular dystrophy type D1 (LGMD D1). Patients with LGMD D1 develop progressive muscle weakness with histology showing fibre damage, autophagic vacuoles, and aggregates. Whils…
View article: Pea and soy protein isolate fractal gels: The role of protein composition, structure and solubility on their gelation behaviour
Pea and soy protein isolate fractal gels: The role of protein composition, structure and solubility on their gelation behaviour Open
The gelation behaviour of two different pea protein isolates and one soy protein isolate were investigated with a focus on the role of the protein properties. Protein solubility was the lowest in pH 3 citrate-phosphate buffer (<10% w/w), i…
View article: Studying the photothermal activation of polydopamine-shelled, phase-change emulsion droplets into microbubbles using small- and ultra-small-angle neutron scattering
Studying the photothermal activation of polydopamine-shelled, phase-change emulsion droplets into microbubbles using small- and ultra-small-angle neutron scattering Open
Polydopamine-shelled perfluorocarbon (PDA/PFC) emulsion droplets are promising candidates for medical imaging and drug delivery applications. This study investigates their phase transition into microbubbles under near-infrared (NIR) illumi…
View article: Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation
Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation Open
Glucagon like peptide-1 (GLP-1) is a hormone produced and released by cells of the gastrointestinal tract following meal ingestion. GLP-1 receptor agonists (GLP-1RA) exhibit kidney-protective actions through poorly understood mechanisms. H…
View article: Basal spot junctions of epithelial tissues respond to morphogenetic forces and regulate Hippo signaling
Basal spot junctions of epithelial tissues respond to morphogenetic forces and regulate Hippo signaling Open
SUMMARY Organ size is controlled by numerous factors including mechanical forces, which are mediated in part by the Hippo pathway. In growing Drosophila melanogaster epithelial tissues, cytoskeletal tension influences Hippo signalling by m…
View article: Removal of the endothelial surface layer via hyaluronidase does not modulate monocyte and neutrophil interactions with the glomerular endothelium
Removal of the endothelial surface layer via hyaluronidase does not modulate monocyte and neutrophil interactions with the glomerular endothelium Open
Objective The endothelial surface layer (ESL), a layer of macromolecules on the surface of endothelial cells, can both impede and facilitate leukocyte recruitment. However, its role in monocyte and neutrophil recruitment in glomerular capi…
View article: Group coactions on two-dimensional Artin-Schelter regular algebras
Group coactions on two-dimensional Artin-Schelter regular algebras Open
We describe all possible coactions of finite groups (equivalently, all group gradings) on two-dimensional Artin-Schelter regular algebras. We give necessary and sufficient conditions for the associated Auslander map to be an isomorphism, a…
View article: The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways
The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways Open
The egress of Candida hyphae from macrophages facilitates immune evasion, but it also alerts macrophages to infection and triggers inflammation. To better define the mechanisms, here we develop an imaging assay to directly and dynamically …
View article: Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination
Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination Open
Resistance to the last-line polymyxins is emerging in multidrug-resistant Klebsiella pneumoniae and phage therapy is a promising alternative. However, phage monotherapy often rapidly causes resistance and few studies have examined antibiot…
View article: Polymeric Nanoneedle Arrays Mediate Stiffness‐Independent Intracellular Delivery (Adv. Funct. Mater. 3/2022)
Polymeric Nanoneedle Arrays Mediate Stiffness‐Independent Intracellular Delivery (Adv. Funct. Mater. 3/2022) Open
Polymeric Nanoneedle Arrays In article number 2104828, Yaping Chen, Nicolas H. Voelcker, Roey Elnathan, and co-workers demonstrate the fabrication of relatively low-cost and high throughput polymeric nanoneedles from cell culture polystyre…