Simon de Beco
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View article: Osmotic pressure induces unexpected relaxation of contractile 3D microtissue
Osmotic pressure induces unexpected relaxation of contractile 3D microtissue Open
Cell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects…
View article: Osmotic pressure induces unexpected relaxation of contractile 3D microtissue
Osmotic pressure induces unexpected relaxation of contractile 3D microtissue Open
Cell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects…
View article: EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization Open
At the basis of cell shape and behavior, the organization of actomyosin and its ability to generate forces are widely studied. However, the precise regulation of this contractile network in space and time is unclear. Here, we study the rol…
View article: Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface
Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface Open
Cellular stress response contributes to epithelial defense in adaptation to environment changes. Galectins play a pivotal role in the regulation of this response in malignant cells. However, precise underlying mechanisms are largely unknow…
View article: Stick-slip dynamics of cell adhesion triggers spontaneous symmetry breaking and directional migration of mesenchymal cells on one-dimensional lines
Stick-slip dynamics of cell adhesion triggers spontaneous symmetry breaking and directional migration of mesenchymal cells on one-dimensional lines Open
Cell motility can be initiated without prior cytoskeleton polarity by the stochastic stick-slip dynamics of cell adhesions.
View article: Emergence of single cell mechanical behavior and polarity within epithelial monolayers drives collective cell migration
Emergence of single cell mechanical behavior and polarity within epithelial monolayers drives collective cell migration Open
The directed migration of cell collectives is essential in various physiological processes, such as epiboly, intestinal epithelial turnover, and convergent extension during morphogenesis as well as during pathological events like wound hea…
View article: Redox-Triggered Control of Cell Adhesion and Deadhesion on Poly(lysine)-<i>g</i>-poly(ethylene oxide) Adlayers
Redox-Triggered Control of Cell Adhesion and Deadhesion on Poly(lysine)-<i>g</i>-poly(ethylene oxide) Adlayers Open
Spontaneous adsorption of poly(lysine)-g-poly(ethylene glycol) comb-like copolymers (PLL-g-PEG) is a versatile mean to coat substrates with polymer layers that resist cell adhesion. We prepared redox cleavable PLL-g-PEG to switch adhesion …
View article: RalB directly triggers invasion downstream Ras by mobilizing the Wave complex
RalB directly triggers invasion downstream Ras by mobilizing the Wave complex Open
The two Ral GTPases, RalA and RalB, have crucial roles downstream Ras oncoproteins in human cancers; in particular, RalB is involved in invasion and metastasis. However, therapies targeting Ral signalling are not available yet. By a novel …
View article: Author response: RalB directly triggers invasion downstream Ras by mobilizing the Wave complex
Author response: RalB directly triggers invasion downstream Ras by mobilizing the Wave complex Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The two Ral GTPases, RalA and…
View article: “Stick-slip dynamics of cell adhesion triggers spontaneous symmetry breaking and directional migration”
“Stick-slip dynamics of cell adhesion triggers spontaneous symmetry breaking and directional migration” Open
Directional cell motility during organism and tissue development, homeostasis and disease requires symmetry breaking. This process relies on the ability of single cells to establish a front-rear polarity, and can occur in absence of extern…
View article: Optogenetic dissection of Rac1 and Cdc42 gradient shaping
Optogenetic dissection of Rac1 and Cdc42 gradient shaping Open
During migration, cells present a polarized activity that is aligned with the direction of motion. This cell polarity is established by an internal molecular circuitry, without the requirement of extracellular cues. At the heart of this ci…
View article: Gradients of Rac1 nanoclusters support spatial patterns of Rac1 signaling
Gradients of Rac1 nanoclusters support spatial patterns of Rac1 signaling Open
The dynamics of the cytoskeleton and cell shape relies on the coordinated activation of RhoGTPase molecular switches. Among them, Rac1 participates to the orchestration in space and time of actin branching and protrusion/retraction cycles …
View article: Mechanosensitive Adaptation of E-Cadherin Turnover across adherens Junctions
Mechanosensitive Adaptation of E-Cadherin Turnover across adherens Junctions Open
In the natural and technological world, multi-agent systems strongly depend on how the interactions are ruled between their individual components, and the proper control of time-scales and synchronization is a key issue. This certainly app…